Results 51 to 60 of about 142,249 (285)

CD28 costimulation regulates genome-wide effects on alternative splicing. [PDF]

PLoS ONE, 2012
CD28 is the major costimulatory receptor required for activation of naïve T cells, yet CD28 costimulation affects the expression level of surprisingly few genes over those altered by TCR stimulation alone.
Manish J Butte, Sun Jung Lee, Jonathan Jesneck, Mary E Keir, W Nicholas Haining, Arlene H Sharpe   +5 more
doaj   +1 more source

Loss of CD28 expression associates with severe T-cell exhaustion in acute myeloid leukemia

Frontiers in Immunology, 2023
IntroductionDespite accumulated evidence in T-cell exhaustion in acute myeloid leukemia (AML), the immunotherapeutic targeting exhausted T cells such as programmed cell death protein 1 (PD-1) blockade in AML failed to achieve satisfying efficacy ...
Yueting Huang, Yueting Huang, Huijian Zheng, Huijian Zheng, Yuwen Zhu, Yuwen Zhu, Yan Hong, Yan Hong, Jie Zha, Jie Zha, Zhijuan Lin, Zhijuan Lin, Zhifeng Li, Zhifeng Li, Caiyan Wang, Caiyan Wang, Zhihong Fang, Zhihong Fang, Xingxing Yu, Xingxing Yu, Long Liu, Long Liu, Bing Xu, Bing Xu   +23 more
doaj   +1 more source

Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells. [PDF]

, 2005
Lipid raft membrane compartmentalization and membrane-associated guanylate kinase (MAGUK) family molecular scaffolds function in establishing cell polarity and organizing signal transducers within epithelial cell junctions and neuronal synapses. Here, we
Miceli, M Carrie, Patel, Viresh, Round, June L, Schoenberger, Stephen P, Tomassian, Tamar, Zhang, Min   +5 more
core  

Clinical and functional characterisation of a novel TNFRSF1A c.605T > A/V173D cleavage site mutation associated with tumour necrosis factor receptor-associated periodic fever syndrome (TRAPS), cardiovascular complications and excellent response to etanercept treatment. [PDF]

, 2008
Objectives: To study the clinical outcome, treatment response, T-cell subsets and functional consequences of a novel tumour necrosis factor (TNF) receptor type 1 (TNFRSF1A) mutation affecting the receptor cleavage site.
B H Belohradsky, C Dejaco, C Duftner, K Huss, M Herold, M Schirmer, P Lohse, S Stojanov   +7 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Peripheral human CD8+CD28+T lymphocytes give rise to CD28–progeny, but IL-4 prevents loss of CD28 expression [PDF]

International Immunology, 1999
At birth, virtually all peripheral CD8(+) T cells express the CD28 co-stimulatory molecule, but healthy human adults accumulate CD28(-)CD8(+) T cells that often express the CD57 marker. While these CD28(-) subpopulations are known to exert effector-type functions, the generation, maintenance and regulation of CD28(-) (CD57(+) or CD57(-)) subpopulations
M, Labalette, E, Leteurtre, C, Thumerelle, C, Grutzmacher, B, Tourvieille, J P, Dessaint   +5 more
openaire   +2 more sources

Kinase-independent function of RIP1, critical for mature T-cell survival and proliferation. [PDF]

, 2016
The death receptor, Fas, triggers apoptotic death and is essential for maintaining homeostasis in the peripheral lymphoid organs. RIP1 was originally cloned when searching for Fas-binding proteins and was later shown to associate also with the signaling ...
Bertin, John, Cai, Yubo, Dowling, John P., Gough, Peter J., Zhang, Jianke   +4 more
core   +2 more sources

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

T cell receptor signaling can directly enhance the avidity of CD28 ligand binding.

PLoS ONE, 2014
T cell activation takes place in the context of a spatial and kinetic reorganization of cell surface proteins and signaling molecules at the contact site with an antigen presenting cell, termed the immunological synapse.
Mariano Sanchez-Lockhart, Ana V Rojas, Margaret M Fettis, Richard Bauserman, Trissha R Higa, Hongyu Miao, Richard E Waugh, Jim Miller   +7 more
doaj   +1 more source

Protein expression from unintegrated HIV-1 DNA introduces bias in primary in vitro post-integration latency models [PDF]

, 2016
To understand the persistence of latently HIV-1 infected cells in virally suppressed infected patients, a number of in vitro models of HIV latency have been developed.
Bonczkowski, Pawel, Borch, Alexandra, De Scheerder, Marie-Angélique, De Spiegelaere, Ward, Koenig, Renate, Malatinková, Eva, Melkova, Zora, Vandekerckhove, Linos   +7 more
core   +1 more source