Results 1 to 10 of about 73,275 (286)
Increased NFAT activity with dual CAR stimulation in CD19xCD22 CAR T-cells is associated with decreased exhaustion and improved survival [PDF]
Journal for ImmunoTherapy of CancerBackground Chimeric antigen receptor (CAR) T-cell therapy is effective in treating B-cell malignancies, however relapse due to lack of CAR persistence and antigen-modulated escape remains common. Multiple strategies to simultaneously target CD19 and CD22
Terry J Fry +5 more
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The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28 [PDF]
Frontiers in Immunology, 2021 Anti-CD19 chimeric antigen receptor (CD19-CAR)-engineered T cells are approved therapeutics for malignancies. The impact of the hinge domain (HD) and the transmembrane domain (TMD) between the extracellular antigen-targeting CARs and the intracellular signaling modalities of CARs has not been systemically studied.
Yannick D. Muller +28 more
openaire +7 more sources
Cytomegalovirus infection in HIV-infected and uninfected individuals is characterized by circulating regulatory T cells of unconstrained antigenic specificity. [PDF]
PLoS ONE, 2017 Cytomegalovirus (CMV) infection is associated with immune-suppression in immune-compromised hosts and old adults. We previously showed that ex vivo CMV restimulation of peripheral blood mononuclear cells (PBMC) of CMV-seropositive volunteers expanded CD4+
Adriana Tovar-Salazar, Adriana Weinberg
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Common gamma chain cytokines promote rapid in vitro expansion of allo-specific human CD8+ suppressor T cells. [PDF]
PLoS ONE, 2011 Human CD8(+) regulatory T cells, particularly the CD8(+)CD28(-) T suppressor cells, have emerged as an important modulator of alloimmunity. Understanding the conditions under which these cells are induced and/or expanded would greatly facilitate their ...
Yuming Yu +8 more
doaj +1 more source
Frontiers in Immunology, 2021 CD28 is well known as a critical T-cell costimulatory receptor involved in T cell activation by binding to its ligands. In this study, CD28 was cloned, and its expression profiles were characterized in flounder (Paralichthys olivaceus); variations of ...
Jing Xing +8 more
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Arming Cytokine-induced Killer Cells With Chimeric Antigen Receptors: CD28 Outperforms Combined CD28–OX40 “Super-stimulation” [PDF]
Molecular Therapy, 2013 Cytokine-induced killer (CIK) cells raised interest for use in cellular antitumor therapy due to their capability to recognize and destroy autologous tumor cells in a HLA-independent fashion. The antitumor attack of CIK cells, predominantly consisting of terminally differentiated CD8(+)CD56(+) cells, can be improved by redirecting by a chimeric antigen
Hombach, Andreas A +2 more
openaire +2 more sources
International Journal of Mycobacteriology, 2020 Background: Mycobacterium tuberculosis is able to survive and persist as an intracellular pathogen by modulating its own metabolism and host immunity. The molecules and mechanisms utilized to accomplish this modulation are not fully understood.
Bhawna Sharma, Bhavyata Dua, Beenu Joshi
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Peripheral blood responses to specific antigens and CD28 in sarcoidosis [PDF]
Respiratory Medicine, 2012 Potential antigens inducing sarcoid inflammation include mycobacterial and auto-antigens. Paradoxically, peripheral anergy to common recall antigens also occurs, possibly due to impaired dendritic cell or regulatory T-cell responses, or impaired T-cell co-stimulation.
Ahmadzai, Hasib +5 more
openaire +2 more sources
miR‐21 sustains CD28 signalling and low‐affinity T‐cell responses at the expense of self‐tolerance
Clinical & Translational Immunology, 2021 Objective miR‐21 is highly expressed in iNKT and activated T cells, but its T‐cell autonomous functions are poorly defined. We sought to investigate the role of miR‐21 in the development and functions of T and iNKT cells, representing adaptive and innate‐
Maya Fedeli +8 more
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Frontiers in Immunology, 2022 Endothelial cells (ECs) can present antigens to circulating effector memory T cells (TEM) and to regulatory T cells (T regs), triggering antigen-specific extravasation at specific sites where foreign antigens are introduced, e.g.
Thomas D. Manes +2 more
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