Results 11 to 20 of about 73,275 (286)
CD28 between tolerance and autoimmunity: the side effects of animal models [version 1; referees: 2 approved] [PDF]
F1000Research, 2018 Regulation of immune responses is critical for ensuring pathogen clearance and for preventing reaction against self-antigens. Failure or breakdown of immunological tolerance results in autoimmunity.
Nicla Porciello +2 more
doaj +4 more sources
IL‐15 preferentially enhances functional properties and antigen‐specific responses of CD4+CD28null compared to CD4+CD28+ T cells [PDF]
Aging Cell, 2011 SummaryOne of the most prominent changes during T‐cell aging in humans is the accumulation of CD28null T cells, mainly CD8+ and also CD4+ T cells. Enhancing the functional properties of these cells may be important as they provide an antigen‐specific defense against chronic infections.
Alonso Arias, Rebeca +6 more
openaire +6 more sources
Generation of Functional CLL-Specific Cord Blood CTL Using CD40-Ligated CLL APC [PDF]
, 2012 PMCID: PMC3526610This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Trojan +56 more
core +11 more sources
Restoration of CD28 Expression in CD28− CD8 + Memory Effector T Cells Reconstitutes Antigen-induced IL-2 Production [PDF]
The Journal of Experimental Medicine, 2003 The control of many persistent viral infections by Ag-specific cytolytic CD8+ T cells requires a concurrent virus-specific CD4+ Th cell response. This reflects in part a requirement of activated effector CD8+ T cells for paracrine IL-2 production as a growth and survival factor.
Topp, Max S. +5 more
openaire +2 more sources
CD28 Costimulatory Domain–Targeted Mutations Enhance Chimeric Antigen Receptor T-cell Function
Cancer Immunology Research, 2021 Abstract An obstacle to the development of chimeric antigen receptor (CAR) T cells is the limited understanding of CAR T-cell biology and the mechanisms behind their antitumor activity. We and others have shown that CARs with a CD28 costimulatory domain drive high T-cell activation, which leads to exhaustion and shortened persistence.
Justin C. Boucher +14 more
openaire +3 more sources
Mediterranean Journal of Hematology and Infectious Diseases, 2023 Multiple myeloma (MM) is a heterogeneous malignancy characterized by the proliferation of abnormal plasma cells in the bone marrow. Multiparametric flow cytometry (MFC) plays a role in the work-up of the disease in view of the aberrant expression of ...
Francesca Fazio +10 more
doaj +1 more source
Клиническая онкогематология, 2022 Background. The population of non-tumor plasma cells in healthy subjects’ bone marrow is known to be fairly heterogeneous. Among them, there may be a small number of CD19–, CD56+, CD45– plasma cells which differ from the main bulk of the normal ...
E. E. Tolstykh +8 more
doaj +1 more source
Human natural killer cell committed thymocytes and their relation to the T cell lineage. [PDF]
, 1993 Recent studies have demonstrated that mature natural killer (NK) cells can be grown from human triple negative (TN; CD3-, CD4-, CD8-) thymocytes, suggesting that a common NK/T cell precursor exists within the thymus that can give rise to both NK cells ...
Lanier, LL +3 more
core +1 more source
Journal of Experimental & Clinical Cancer Research, 2023 Background The applicability and therapeutic efficacy of specific personalized immunotherapy for cancer patients is limited by the genetic diversity of the host or the tumor.
Chia-Hung Chen +15 more
doaj +1 more source
Cell Reports, 2018 Summary: Th17 cells drive autoimmune disease but also control commensal microbes. A common link among antigens from self-proteins or commensal microbiota is relatively low activation of T cell receptor (TCR) and costimulation signaling.
Shankar Revu +7 more
doaj +1 more source