Results 131 to 140 of about 286,717 (340)

Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia

Advanced Science, EarlyView.
Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen, Jiale Wei, Shibing Tang, Dongliang Wu, Liangyi Zong, Shuyuan Ma, Qing Xiong, Ruijie Gong, Siyuan Xu, Chuxuan Peng, Qin Feng, Songchen Liu, Qitong Liu, Yuhua Ye, Quan Zhao, Cheng Luo, Peng Huang, Zhihai Li, Xiangqian Kong, Xianjiang Lan   +19 more
wiley   +1 more source

Bone marrow characterization in sickle cell disease: inflammation and stress erythropoiesis lead to suboptimal CD34 recovery [PDF]

, 2019
Alexis Leonard, Aylin Bonifacino, Venina Marcela Dominical, Min Luo, Juan J. Haro‐Mora, Selami Demirci, Naoya Uchida, Francis J. Pierciey, John F. Tisdale   +8 more
openalex   +1 more source

Lapine CD133+CD34+ endothelial progenitor cells for musculoskeletal research in preclinical animal trials [PDF]

, 2020
Hitesh Chopra, Yuanyuan Han, Chengfei Zhang, Ehn Pow   +3 more
openalex   +1 more source

Bone Marrow Mesenchymal Stem Cell Hydrogel‐Mediated Fibroblast Reprogramming Restores Intestinal Function in Adhesive Small Bowel Obstruction

Advanced Science, EarlyView.
Conceptual diagram and schematic illustration of microenvironmental changes in individuals with ASBO before and after treatment. BMSC@Gel therapy transforms the ASBO microenvironment from an inflammatory, fibrotic state with aberrant matrix deposition and barrier dysfunction to a regenerative state with reduced inflammation and improved structural ...
Lihong Zheng *, Junrong Zhang *, Zhengyuan Huang *, Zhenliang Lin, Jin Zhang, Da Zhang, Ping Hou, Xianqiang Chen   +7 more
wiley   +1 more source

5613327 KNOCK-DOWN OF AUTOPHAGY-RELATED GENE 5 (ATG5) EXPRESSION IN THALASSEMIC CD34+ CELLS LEADS TO AMELIORATION OF ERYTHROPOIESIS

, 2023
A. Psychogiou, E. Tsempera, E. Kalafati, E. Voskaridou, E. Drakopoulou, N.P. Anagnou   +5 more
openalex   +1 more source

Targeted 2‐Deoxy‐D‐Ribose Delivery by Biomimetic Nanoplatform Activates EGFR for Accelerated Heart Valve Endothelialization

Advanced Science, EarlyView.
This study develops a biomimetic nanoplatform using erythrocyte membrane‐camouflaged, CD144 antibody‐functionalized nanoparticles to deliver 2‐deoxy‐D‐ribose (2dDR). This system promotes heart valve endothelialization by enhancing endothelial cell migration and proliferation via EGFR activation, while improving hemocompatibility.
Xiang Qiu, Gaofeng Li, Wenyi Wan, Jinsheng Li, Ge Yan, Shijie Wang, Xiuqi Hu, Zongqi Han, Yazheng Shan, Ying Zhou, Nianguo Dong, Weihua Qiao   +11 more
wiley   +1 more source

Investigating the extremes of the continuum of paracrine functions in CD34⁻/CD31⁺ CACs across diverse populations [PDF]

, 2016
Rian Q. Landers‐Ramos, Ryan M. Sapp, Emily VandeWater, Jennifer Macko, Shawn Robinson, Yan Wang, Eva R. Chin, Espen E. Spangenburg, Steven J. Prior, James M. Hagberg   +9 more
openalex   +1 more source

Integrative Multi‐Omics Analysis Uncovers Immunological Phenotypes Predictive of Combinatorial Immunotherapy Response in Gastric Cancer

Advanced Science, EarlyView.
Current understanding of gastric cancer immunity remains inadequate, leading to suboptimal immunotherapy outcomes. This study introduces a novel tumor immune microenvironment classification system (Inflamed, Desert, and Excluded), advancing traditional histopathological or molecular subtyping toward a functional immunological framework.
Jianchao Wang, Wenfang Zhang, Jiyang Zhang, Chenhui Zhao, Wei Zhang, Menghan Fang, Fangfang Chen, Zhida Wu, Xiaoya Xu, Ziqing Yu, Qiong Zhu, Yi Shi, Dadong Zhang, Xiaofeng Chen, Gang Chen   +14 more
wiley   +1 more source

Utility of Microvessel Density (MVD) by CD34 in Different Histological Grades of Oral Squamous Cell Carcinoma

, 2021
Ayushi Singh, Miheer Jagtap, Samarth Shukla, Sunita Vagha   +3 more
openalex   +1 more source

Comparison of CD34⁺ cells isolated from frozen cord blood and fresh adult peripheral blood of sickle cell disease patients in gene correction of the sickle mutation at late‐stage erythroid differentiation [PDF]

, 2021
Chutima Kumkhaek, Naoya Uchida, John F. Tisdale, Griffin P. Rodgers   +3 more
openalex   +1 more source