Results 121 to 130 of about 220,523 (312)
, 2007 We compared the cell division behavior of CD34(-) and CD34(+) (CD33/CD38/CD71)-negative (Lin(-)) CD133(+) cord blood cells stimulated with the cytokines Flt3-ligand, stem cell factor, and thrombopoietin. Within a 4-day time frame, Lin(-)CD34(-) CD133(+) (
Götze, KS;Schiemann, M;Marz, S;Jacobs, VR;Debus, G;Peschel, C;Oostendorp, RA
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Animal Models and Experimental Medicine, EarlyView.This study provides the first evidence of natural TP53 variation between tree shrew subspecies and identifies somatic TP53 mutations in spontaneous tree shrew sarcomas. The high structural and functional conservation of tree shrew p53 with humans supports its utility as a relevant model for TP53‐related cancer research.
Yingying Cao +4 more
wiley +1 more source
Optimal proportion CD34+ cells to CD34− cells for effective EPC differentiation.
, 2014 The optimal proportion of CD34+ cells to CD34− cells was estimated by coculture of CD34+ cells (500 cells per 35-mm dish) with various densities of CD34− cells (100, 50, 20, 10, 5, 2.5, 1.7, 1.25, 1, 0.3, and 0% of CD34+ cells).
Da-Yeon Kim (622779) +14 more
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Arthritis &Rheumatology, EarlyView.Objective The hematopoietic system maintains homeostasis by balancing myeloid and lymphoid cell production in the bone marrow (BM). In response to increased hematopoietic demand, extramedullary hematopoiesis (EMH) may occur in nonlymphoid organs. We investigated the role of EMH and kidney‐resident hematopoietic stem and progenitor cells (HSPCs) in ...
Hansol Yi +9 more
wiley +1 more source
, 2015 Translocation of the mixed-lineage leukemia (MLL) gene with AF4, AF9, or ENL results in acute leukemia with both lymphoid and myeloid involvement.
Mizutani, Shuki +39 more
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E-cadherin/CD34 double immunostaining in placental diagnosis
Placental foetal vascular malperfusion (FVM) may be responsible for complicated foetal or neonatal condition. By highlighting endothelial fragmentation, the double E-cadherin/CD34 immunostain highlights distal villous endothelial fragmentation of recent ...
Jerzy Stanek
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Human Fibroblast–Myeloid Cell Tissue Atlas Across the Lungs, Synovium, Skin, and Heart
Arthritis &Rheumatology, EarlyView.Objective The availability of single‐cell RNA sequencing (scRNAseq) data in different tissues and disease states provides an opportunity to compare cellular subsets and identify common and unique cellular activation. In this study, we aimed to characterize shared and tissue‐specific myeloid and stromal phenotypes and to uncover key cellular subtypes ...
Lucy MacDonald +9 more
wiley +1 more source
Arthritis &Rheumatology, EarlyView.Objective Synovial fibroblasts directly contribute to inflammation and damage in immune‐mediated inflammatory arthritis. CD248/endosialin is expressed by fibroblasts in the synovium, is highly up‐regulated during inflammation, and has been proposed as a potential therapeutic target.
Samuel Kemble +12 more
wiley +1 more source
Tumor size in Cd34−/− surpasses Cd34+/+ by day 19, due to hematopoietic loss of CD34.
, 2013 A, Average s.c.-injected tumor masses 19 days post-injection in Cd34+/+ and Cd34−/− animals. (Pooled from three experiments, Cd34+/+ n = 15, Cd34−/− n = 16).
Andrew I. Minchinton (353466) +7 more
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Implementation and use of risk minimization control tools in the EU: A multistakeholder survey
British Journal of Clinical Pharmacology, EarlyView.Aims This study characterized stakeholders' experiences with national implementation of risk minimization control tools (RMCTs), such as healthcare professional qualification, healthcare facility accreditation and medical intervention prior to treatment initiation, for eight medicinal products across eight European Union countries. Methods We conducted
Sharon C. M. Essink +21 more
wiley +1 more source