Results 131 to 140 of about 220,523 (312)

Antifibrotic Activity of Human Placental Amnion Membrane-Derived CD34(+) Mesenchymal Stem/Progenitor Cell Transplantation in Mice With Thioacetamide-Induced Liver Injury

, 2017
Liver fibrosis represents the end stage of chronic liver inflammatory diseases and is defined by the abnormal accumulation of extracellular matrix in the liver. Advanced liver fibrosis results in cirrhosis, liver failure, and portal hypertension.
Lee, Po-Huang;Tu, Chi-Tang;Hsiao, Chih-Chiang;Tsai, Ming-Song;Ho, Cheng-Maw;Cheng, Nai-Chen;Hung, Tzu-Min;Shih, Daniel Tzu-Bi, 何承懋;鄭乃禎;李伯皇   +1 more
core   +1 more source

Affinity Peptides With pH Sensitivity for the Enrichment of CD38+ Cells

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The selective enrichment of cell populations based on surface markers is critical for the advancement of gene and cell therapies. Current antibody‐based cell isolation methods, such as fluorescence‐ and magnetic‐activated cell sorting (FACS and MACS), offer high specificity but are limited by scalability, cost, and potential adverse effects on
Gabrielle Rusch, Mickael Meyer, I. Mohamed Irfan, Carson Huber, Joseph Burclaff, Scott T. Magness, Stefano Menegatti, Michael Daniele   +7 more
wiley   +1 more source

The ALDH activity of CD34+CD38– HSC is higher than the CD34– bulk in CD34-negative AML.

, 2013
The aldefluor assay was performed on the bulk of cells (AML-464). Cells were subsequently labeled with anti-CD45 PERCP, anti-CD34 PC7, anti-CD38 APC and anti-CD56 PE. (A) The CD34+CD38– stem cells (A, left panel, orange) were negative for CD56 (A, middle
Lisa A. Min (482349), Gerrit J. Schuurhuis (482346), Monique Terwijn (482350), Nick A. de Jonge (482351), Alexander N. Snel (482353), Sonja Zweegman (482354), Gert J. Ossenkoppele (168366), Floris Wouters (482348), Michael H. Meel (482347), Linda Smit (482355), Angele Kelder (482352)   +10 more
core   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

Variability in responsiveness to lovastatin of the primitive CD34(+) AML subfraction compared to normal CD34(+) cells

, 2008
In the present study, we questioned whether the cholesterol synthesis inhibitor lovastatin potentiates the cytotoxicity of chemotherapeutic agents in the primitive CD34(+) subpopulation of acute myeloid leukemia (AML) cells. AML mononuclear cells (n = 17)
Sluiter, Wim J., de Vries, Elisabeth G. E.; id_orcid, Edo Vellenga, Susan D. P. W. M. de Jonge-Peeters, Folkert Kuipers, van der Weide, Karen, Wim J. Sluiter, Jonge-Peeters, Susan D. P. W. M., Karen van der Weide, de Vries, Elisabeth G. E., Kuipers, Folkert, Weide, Karen, Kuipers, Folkert; id_orcid, de Jonge-Peeters, Susan D. P. W. M., Elisabeth G. E. de Vries, Vellenga, Edo, Vries, Elisabeth G. E.   +16 more
core   +1 more source

Biomaterials for modulating cellular responses of endogenous tendon stem/progenitor cells: A promising avenue for tendon regeneration

BMEMat, EarlyView.
This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu, Renwang Sheng, Mumin Cao, Ludvig J. Backman, Yucheng Gao, Hao Wang, Cheng Zhang, Jialin Chen, Wei Zhang, Yunfeng Rui   +9 more
wiley   +1 more source

Transient loading of CD34+ hematopoietic progenitor cells with polystyrene nanoparticles

, 2017
Sarah Deville,1,2 Wahyu Wijaya Hadiwikarta,1 Nick Smisdom,1,2 Bart Wathiong,1,3 Marcel Ameloot,2 Inge Nelissen,1 Jef Hooyberghs1,3 1VITO, Flemish Institute for Technological Research, Mol, Belgium; 2Biomedical Research Institute, Hasselt University ...
Deville S, Hooyberghs J, Hadiwikarta WW, Nelissen I, Smisdom N, Wathiong B, Ameloot M   +6 more
core  

Progenitor cell trafficking in physiologic conditions and in myeloproliferative diseases: quantification of CD34+ cells by polymerase chain reaction. [PDF]

, 2005
BACKGROUND AND OBJECTIVES Previous studies using flow cytometry have shown that CD34+ cell trafficking is increased in patients with chronic idiopathic myelofibrosis. Few data exist on physiologic CD34 + cell trafficking and the quantification of very
Oppliger Leibundgut, Elisabeth, Brunold, Claudio, Schmid, Jean-Paul, Schroeder, Verena, Seiler, Christian, Marti, Dorothee, Zwicky, Caroline, Tobler, Andreas, Horn, Michael Peter   +8 more
core  

Caveolin‐1 enriched apoptotic bodies derived from oral hard palate orchestrate bone remodeling to treat heterotopic ossification

BMEMat, EarlyView.
Downregulated CAV1 in HO is restored via apoptotic bodies from PMSCs, which reprogram bone remodeling by delivering CAV1 to target cells, highlighting the therapeutic role of EV subtypes in heterotopic ossification. Abstract Heterotopic ossification (HO) is a pathological process characterized by ectopic bone formation in non‐osseous tissues, with an ...
Yuchen Wang, Like Tang, Zhou Yu, Wenjin Cai, Qifeng Jiang, Zhikang Wang, Yitong Chen, Kaichen Lai, Ying Wang, Tim Forouzanfar, Chiyuan Ma, Gang Wu, Tingben Huang, Guoli Yang   +13 more
wiley   +1 more source

Lipid droplet profiling during neutrophil differentiation by stimulated Raman scattering microscopy

Biotechnology Progress, EarlyView.
Abstract Lipid droplets (LDs) are dynamic organelles that serve as metabolic hubs and emerging regulators of immune cell fate. Although LDs have been implicated in immune regulation, how LD metabolism is remodeled during neutrophil differentiation and how stage‐specific LD dynamics shape mature neutrophil function remain poorly defined.
Ting‐Jung Sung, Bin Dong, Jingqiao Shen, Yan Tan, Chi Zhang, Xiaoping Bao   +5 more
wiley   +1 more source