Results 261 to 270 of about 286,717 (340)

Gene therapy supports long-term reconstitution of patient hematopoietic stem cells in deficiency of adenosine deaminase 2. [PDF]

Mol Ther Methods Clin Dev
Rigamonti C, Bulté D, Barzaghi F, Mesa-Nuñez C, Basso-Ricci L, Pettinato E, Visconti C, Degl'Innocenti S, Gazzo F, Benedicenti F, Arévalo S, Quaranta P, Sanvito F, Caorsi R, Schena F, Lupia M, Federici S, Insalaco A, De Benedetti F, Scala S, Miano M, Conti F, Cicalese MP, Montini E, Gattorno M, Dufour C, Aiuti A, Mortellaro A.   +27 more
europepmc   +1 more source

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

European Journal of Haematology, EarlyView.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source

Revascularization of human ovarian cortical grafts is not equally efficient from both sides of the cortex tissue. [PDF]

Front Endocrinol (Lausanne)
Cheng J, Ruan X, Du J, Jin F, Gu M, Jin J, Li Y, Li Y, Wang Z, Jiang L, Zhang M, Liu A, Mueck AO.   +12 more
europepmc   +1 more source

Improving cellular therapy operations through pre‐harvest measurement of peripheral CD34‐positive cell counts in allogeneic stem cell harvest [PDF]

Shuhei Kurosawa, Kyoko Haraguchi, Yunoka Honma, Fuyuko Kawai, Moemi Ishiwada, Ryoko Iimura, Rei Watanabe, Sayuri Ishibashi, Kae Sakuma, Kiyomi Narishima, Misako Nishimura, Takashi Toya, Hiroaki Shimizu, Yuho Najima, Takeshi Kobayashi, Noriko Doki, Yoshiki Okuyama   +16 more
openalex   +1 more source

Whole Blood Transcriptomic Analysis of Sickle Cell Trait

European Journal of Haematology, EarlyView.
ABSTRACT Sickle cell trait (SCT) is the heterozygous carrier state for the HBB missense variant which causes sickle cell disease (SCD). SCT has been associated with increased risk of venous thromboembolism and chronic kidney disease as well as alterations in clinical laboratory parameters. To investigate differential gene expression in SCT, we used RNA
Mari Johnson, Yanwei Cai, Ana Gabriela Vasconcelos, Peter Orchard, Paul L. Auer, Guillaume Lettre, Jia Wen, Nora Franceschini, Charles Kooperberg, Wei Sun, Li Hsu, Laura M. Raffield, Alex P. Reiner   +12 more
wiley   +1 more source

MDSC subpopulation dynamics predict disease evolution: a multidimensional biomarker framework for risk assessment in MDS. [PDF]

Clin Exp Med
Hu Z, Hu Z, Zhang Y, Hua M, Huang S, Wang Y, Yang Y, Zhao P, Zhou Y.   +8 more
europepmc   +1 more source

The effect of CD34-capturing coronary stents with abluminal sirolimus coating on endothelial coverage

, 2016
Guilielmus H.J.M. Ellenbroek, Leo Timmers, Freek Nijhoff, Erik Ligtenberg, Steve Rowland, Joris van der Post, Gerard Pasterkamp, I.E. Hoefer   +7 more
openalex   +2 more sources

Adult granulosa cell tumours of the testis analogous to ovarian counterparts are exceptionally rare: analysis of a multicentric series and review of the literature

Histopathology, EarlyView.
Assessment of twenty testicular AGCTs with two different next‐generation sequencing (NGS) panels reveals differences with ovarian AGCTs, including absence of hotspot FOXL2 variants. Aims Testicular adult granulosa cell tumours (AGCTs) are rare and show several clinical–pathological differences with their ovarian counterparts.
Costantino Ricci, Dario de Biase, Thais Maloberti, Agnese Orsatti, Thomas M Ulbright, Muhammad T Idrees, Esther Oliva, Kristine Cornejo, João Lobo, Kvetoslava Michalova, Maria Rosaria Raspollini, Sean R Williamson, Geert JLH van Leenders, Chia‐Sui Kao, Fiona Maclean, Ankur R Sangoi, Adeboye O Osunkoya, Michelangelo Fiorentino, Antonio De Leo, Giovanni Tallini, Andres Martin Acosta   +20 more
wiley   +1 more source

Laminar CD34+ membranous cells with mechanosensitive properties in subcutaneous fascia of the abdominal midline. [PDF]

Sci Rep
Huang H, Mei L, Zhang Z, Yue J, Dai M, Lu L, Yang M, Fan L, Yang T, Chen Q.   +9 more
europepmc   +1 more source

Novel NOTCH3 alteration expanding the molecular spectrum of pericytic tumours: report of two cases

Histopathology, EarlyView.
Introduction Myofibromas are part of the pericytic tumour family, which includes myopericytomas, glomus tumours and angioleiomyomas. While they typically display benign behaviour when arising in the skin and subcutaneous tissues of the head and neck, rare aggressive variants have been reported, particularly those with visceral or intracranial ...
Irena Antonia Ungureanu, Megane Le Quang, Rihab Azmani, Marie Ancelle, Henri Margot, Guillaume Chotard, François Le Loarer, Nathalène Truffaux   +7 more
wiley   +1 more source