Results 61 to 70 of about 5,353 (192)

Characterization of CD123 expression by mast cells in systemic mastocytosis with multicolor flow cytometry

Cytometry Part B: Clinical Cytometry, Volume 110, Issue 5, Page 326-334, September 2026.
Abstract Systemic mastocytosis (SM) is a clonal mast cell (MC) disorder characterized by aberrant immunophenotypes, including expression of CD25, CD2, and occasionally CD30. CD123, the α‐subunit of the interleukin‐3 receptor, is a therapeutic target in hematologic malignancies and has been reported to be expressed on neoplastic MCs by ...
Ryan C. Shean, Tracy I. George, David P. Ng   +2 more
wiley   +1 more source

Antigen Expression Varies Significantly between Molecular Subgroups of Acute Myeloid Leukemia Patients:Clinical Applicability Is Hampered by Establishment of Relevant Cutoffs

, 2021
INTRODUCTION: In this single-center study of 268 acute myeloid leukemia (AML) patients, we have tested if a subset of 4 routinely employed immunophenotypic stem cell-associated markers correlated with the presence of recurrently mutated genes and if the ...
Herborg, Laura Laine, Nederby, Line, Hokland, Peter, Brøndum, Rasmus Froberg, Roug, Anne Stidsholt, Brøndum, Rasmus Froberg; id_orcid, Hansen, Maria   +6 more
core   +1 more source

Supplementary Figure 2 from A Leukemia-Associated CD34/CD123/CD25/CD99⁺ Immunophenotype Identifies <i>FLT3</i>-Mutated Clones in Acute Myeloid Leukemia

, 2023
<p>Supplementary Figure 2. MPFC detection limit.</p>
Francesco Lo-Coco, Luca Battistini, Adriano Venditti, Sergio Amadori, Giorgio Bernardi, Giovanna Borsellino, Maria Irno Consalvo, Nélida I. Noguera, Mariadomenica Divona, Luca Maurillo, Francesca Gargano, Marco De Bardi, Francesco Buccisano, Michela Cittadini, Serena Lavorgna, Gisella Guerrera, Tiziana Ottone, Daniela F. Angelini   +17 more
openaire   +1 more source

hMICL and CD123 in combination with a CD45/CD34/CD117 backbone – a universal marker combination for the detection of minimal residual disease in acute myeloid leukaemia [PDF]

British Journal of Haematology, 2013
SummaryReal‐time quantitative polymerase chain reaction (qPCR) has been extensively validated for the detection of minimal residual disease (MRD) in acute myeloid leukaemia (AML). Meanwhile, multicolour flow cytometry (MFC) has received less attention because the so‐called leukaemia‐associated immunophenotypes (LAIPs) are generally of lower sensitivity
Roug, Anne S., Larsen, Hanne O., Nederby, Line, Just, Tom, Brown, Gordon, Nyvold, Charlotte G., Ommen, Hans B., Hokland, Peter   +7 more
openaire   +5 more sources

Flow cytometric identification of plasmacytoid dendritic cells in acute myeloid leukaemia: Challenges and practical considerations

British Journal of Haematology, EarlyView.
Mariana S. Vieira, Pietro B. Belmonte, Natália A. Marcondes, Raquel Q. Vidal, Flavo B. Fernandes, Liane N. Rotta   +5 more
wiley   +1 more source

Defining a Therapeutic Window for Venetoclax in Post‐Transplant Maintenance Therapy for High‐Risk Acute Myeloid Leukemia and Myelodysplastic Syndromes

Hematological Oncology, Volume 44, Issue 5, September 2026.
ABSTRACT Patients with high‐risk acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) continue to face a substantial risk of relapse after allogeneic hematopoietic stem cell transplantation (allo‐HSCT), which remains a leading cause of treatment failure.
Cuicui Lyu, Tianle Xie, Yedi Pu, Xianshuang Luan, Xia Xiao, Mingfeng Zhao, Hairong Lyu   +6 more
wiley   +1 more source

Data from A Leukemia-Associated CD34/CD123/CD25/CD99⁺ Immunophenotype Identifies <i>FLT3</i>-Mutated Clones in Acute Myeloid Leukemia

, 2023
<div>Abstract<p><b>Purpose:</b> We evaluated leukemia-associated immunophenotypes (LAIP) and their correlation with fms-like tyrosine kinase 3 (<i>FLT3</i>) and nucleophosmin (<i>NPM1</i>) gene mutational status in order to contribute a better identification of patients at highest risk of relapse in acute
Francesco Lo-Coco, Luca Battistini, Adriano Venditti, Sergio Amadori, Giorgio Bernardi, Giovanna Borsellino, Maria Irno Consalvo, Nélida I. Noguera, Mariadomenica Divona, Luca Maurillo, Francesca Gargano, Marco De Bardi, Francesco Buccisano, Michela Cittadini, Serena Lavorgna, Gisella Guerrera, Tiziana Ottone, Daniela F. Angelini   +17 more
openaire   +1 more source

Supplementary Table 4 from A Leukemia-Associated CD34/CD123/CD25/CD99⁺ Immunophenotype Identifies <i>FLT3</i>-Mutated Clones in Acute Myeloid Leukemia

, 2023
<p>Supplementary Table 4. MPFC analysis of AML bone marrow sample according to FLT3 or NPM1 mutational status.</p>
Francesco Lo-Coco, Luca Battistini, Adriano Venditti, Sergio Amadori, Giorgio Bernardi, Giovanna Borsellino, Maria Irno Consalvo, Nélida I. Noguera, Mariadomenica Divona, Luca Maurillo, Francesca Gargano, Marco De Bardi, Francesco Buccisano, Michela Cittadini, Serena Lavorgna, Gisella Guerrera, Tiziana Ottone, Daniela F. Angelini   +17 more
openaire   +1 more source

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, Volume 59, Issue 9, September 2026.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

Supplementary Material for: Antigen Expression Varies Significantly between Molecular Subgroups of Acute Myeloid Leukemia Patients: Clinical Applicability Is Hampered by Establishment of Relevant Cutoffs

, 2020
Introduction: In this single-center study of 268 acute myeloid leukemia (AML) patients, we have tested if a subset of 4 routinely employed immunophenotypic stem cell-associated markers correlated with the presence of recurrently mutated genes and if the ...
Department of Haematology, Aalborg University Hospital, The Faculty of Medicine, Hokland, Peter, Klinik Kirurgi og Kræftbehandling, Department of Clinical Medicine, Regional Hospital Southern Denmark, University of Copenhagen, Roug, Anne Stidsholt, Aarhus University, Brøndum, Rasmus Froberg; id_orcid, AI for the People, Herborg, Laura Laine, Nederby, Line, Department of Communication and Psychology, Department of Culture and Learning, Hansen, Maria   +16 more
core   +2 more sources