Results 1 to 10 of about 79,854 (126)

Mutational analysis of the alpha subunit of the human interleukin-3 receptor [PDF]

Blood, 1996
Abstract The alpha subunit of the human interleukin-3 receptor (IL-3R alpha) is a 70-kD glycoprotein member of the hematopoietin receptor superfamily. This protein associates with a beta subunit common to the receptors for IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF) to form a high-affinity receptor for IL-3.
A P, Rapoport, S, Luhowskyj, P, Doshi, J F, DiPersio   +3 more
exaly   +4 more sources

The murine interleukin-3 receptor alpha subunit gene: chromosomal localization, genomic structure, and promoter function [PDF]

Blood, 1995
The interleukin-3 receptor (IL-3R) is composed of alpha and beta subunits, members of the class I cytokine receptor family. Here we describe isolation and characterization of the chromosomal gene for the mouse IL-3R alpha subunit (mIL-3R alpha). Whereas the human IL-3R alpha gene is tightly linked with the granulocyte-macrophage colony- stimulating ...
I, Miyajima, L, Levitt, T, Hara, M A, Bedell, N G, Copeland, N A, Jenkins, A, Miyajima   +6 more
exaly   +3 more sources

An analysis of the cytokine profile of platelet-rich plasma when combined in vitro with low versus high molecular weight hyaluronic acid [PDF]

Bone & Joint Research
Aims: Platelet-rich plasma (PRP) and hyaluronic acid (HA) are nonoperative treatments for osteoarthritis (OA) of large joints. Clinically, some endorse the use of both methods together for a theoretical synergistic effect therapeutically, with limited ...
David J. Ellenbogen, Simarjeet Puri, Rishi Chatterji, Joseph Seta, Adam Miller, Ian Al’khafaji, Therese Bou-Akl, Paula Pawlitz, David C. Markel   +8 more
doaj   +2 more sources

Pancreatic β cell interleukin-22 receptor subunit alpha 1 deficiency impairs β cell function in type 2 diabetes via cytochrome b5 reductase 3

Cell Reports
Summary: Impaired β cell function is a hallmark of type 2 diabetes (T2D), but the underlying cellular signaling machineries that regulate β cell function remain unknown. Here, we identify that the interleukin-22 receptor subunit alpha 1 (IL-22RA1), known
Fan Yu, Shuting Xie, Tongyu Wang, Yeping Huang, Hong Zhang, Danfeng Peng, Yifan Feng, Yumei Yang, Zheyu Zhang, Yunxia Zhu, Zhuoxian Meng, Rong Zhang, Xiaomu Li, Hao Yin, Jie Xu, Cheng Hu   +15 more
doaj   +3 more sources

Stapokibart (CM310) in Atopic Dermatitis: A Narrative Review of a Next-Generation IL-4Rα Antagonist [PDF]

Dermatology Practical & Conceptual
Introduction: The interleukin (IL)-4/IL-13 signaling pathway is central to the pathogenesis of atopic dermatitis (AD). Stapokibart (CM310) is a novel humanized monoclonal antibody targeting the IL-4 receptor alpha (IL-4Rα) subunit.
Esmeraldito Ferreira, Tong Wu, Yongfeng Chen   +2 more
doaj   +2 more sources

Sesamoside Alleviates Inflammatory Response in Septic Shock-Associated Acute Liver Injury by Modulating the NF-κB/MAPK Signaling Pathway [PDF]

Dose-Response
Objectives Acute liver injury, a lethal septic shock complication with scarce treatments, lacks research on Sesamoside’s liver-protective function.
Xinjie Zhao, Xiaohua Hao, Jialu Yuan, Yanru Zhang, Shizhuo Chen, Shuaijie Wei, Haoxuan Gao, Keqing Tian, Dan Song   +8 more
doaj   +2 more sources

Comparison of Immune-Related Gene Expression in Two Chicken Breeds Following Infectious Bronchitis Virus Vaccination

Animals, 2023
This study aims to identify the immune-related genes and the corresponding biological pathways following infectious bronchitis virus vaccination in Taiwan Country and White Leghorn chicken breeds. Transcriptomic analyses of the spleen of these two breeds
Schwann Chuwatthanakhajorn, Chi-Sheng Chang, Kannan Ganapathy, Pin-Chi Tang, Chih-Feng Chen   +4 more
doaj   +1 more source

Improved Activity against Acute Myeloid Leukemia with Chimeric Antigen Receptor (CAR)-NK-92 Cells Designed to Target CD123

Viruses, 2021
Anti-cancer activity can be improved by engineering immune cells to express chimeric antigen receptors (CARs) that recognize tumor-associated antigens. Retroviral vector gene transfer strategies allow stable and durable transgene expression.
Michael A. Morgan, Arnold Kloos, Daniela Lenz, Nadine Kattre, Juliette Nowak, Marco Bentele, Maximilian Keisker, Julia Dahlke, Katharina Zimmermann, Martin Sauer, Michael Heuser, Axel Schambach   +11 more
doaj   +1 more source

Transcriptomic patterns in early-secretory and mid-secretory endometrium in a natural menstrual cycle immediately before fertilization and embryo transfer [PDF]

Obstetrics & Gynecology Science, 2023
Objective This study aimed to evaluate the endometrial transcriptomic patterns in the early secretory phase (ESP) and mid-secretory phase (MSP) of the natural menstrual cycle before in vitro fertilization and embryo transfer (IVF-ET).
Sung Pil Choo, Inha Lee, Jae-Hoon Lee, Dowon Lee, Hyemin Park, Joo Hyun Park, SiHyun Cho, Young Sik Choi   +7 more
doaj   +1 more source

Impaired interleukin‐3 (IL‐3) response of the A/J mouse is caused by a branch point deletion in the IL‐3 receptor alpha subunit gene. [PDF]

The EMBO Journal, 1995
Interleukin-3 (IL-3) alone does not support hematopoietic colony formation of bone marrow cells from the A/J mouse. To elucidate the molecular lesion in A/J mice, we examined expression of the alpha and beta subunits of the IL-3 receptor (IL-3R). While IL-3R beta was normally expressed, IL-3R alpha was not detectable on the surface of A/J-derived cells
M, Ichihara, T, Hara, M, Takagi, L C, Cho, D M, Gorman, A, Miyajima   +5 more
openaire   +2 more sources