Results 31 to 40 of about 20,065,044 (264)

Non-canonical IL‑22 receptor signaling remodels the oral mucosal barrier during Candida albicans immunosurveillance

Nature Communications
Mucosal barrier integrity is vital for homeostasis with commensal organisms while preventing pathogen invasion. Here we show that fungal-induced immunosurveillance enhances resistance to fungal outgrowth and tissue invasion by remodeling the oral mucosal
Nicolas Millet, Jinendiran Sekar, Norma V. Solis, Jian Miao, Antoine Millet, Felix E. Y. Aggor, Asia Wildeman, Melissa E. Cook, Amirhossein Davari, Brian M. Peters, Michail S. Lionakis, Sarah L. Gaffen, Nicholas Jendzjowsky, Scott G. Filler, Marc Swidergall   +14 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Salivary peptidomic profiling of chronic gingivostomatitis in cats by matrix‐assisted laser desorption/ionization‐time‐of‐flight mass spectrometry and nanoscale liquid chromatography‐tandem mass spectrometry

Journal of Veterinary Internal Medicine
Background Chronic gingivostomatitis in cats (FCGS) is a moderately to severely painful condition, potentially caused by inadequate immune response to oral antigenic stimulation. Salivary peptidome analysis can identify inflammatory protein mediators and
Sekkarin Ploypetch, Apisit Pornthummawat, Sittiruk Roytrakul, Janthima Jaresitthikunchai, Narumon Phaonakrop, Sabrina Wahyu Wardhani, Sitthichok Lacharoje, Somporn Techangamsuwan   +7 more
doaj   +1 more source

Distinct damage levels and transcriptional responses of lung in Hezuo pigs and Bama pigs during cold exposure [PDF]

Animal Bioscience
Objective The aim of the present study is to compare cold adaptation mechanisms between cold-tolerant Hezuo and cold-sensitive Bama pigs. Methods A total of 40 healthy pigs (75 days old), including 20 Hezuo pigs and 20 Bama pigs, were used in this study.
Yajuan Li, Xiaoli Gao, Yating Zhang, Shuangbao Gun   +3 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Deciphering genetic causality between plasma BDNF and 91 circulating inflammatory proteins through bidirectional mendelian randomization

Scientific Reports
Prior studies reported an association between the levels of brain-derived neurotrophic factor (BDNF) circulating in the bloodstream and those of different inflammatory factors. However, their causal relationship remains unclear.
Yesheng Sun, Xizi Shi, Melanie Ohm, Martin Korte, Marta Zagrebelsky   +4 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Interleukin-6 and granulocyte colony-stimulating factor as predictors of the prognosis of influenza-associated pneumonia

BMC Infectious Diseases, 2022
Background Pneumonia is a common complication of influenza and closely related to mortality in influenza patients. The present study examines cytokines as predictors of the prognosis of influenza-associated pneumonia.
Jiaying Zhang, Jingxia Wang, Yiwen Gong, Yudan Gu, Qiangqiang Xiang, Ling-Ling Tang   +5 more
doaj   +1 more source

The effect of exercise on plasma soluble IL-6 receptor concentration: a dichotomous response [PDF]

, 2010
The aim of this article is to review current literature on the response of soluble interleukin-6 receptor to exercise and identify a potential role for sIL-6R in skeletal muscle function.
Stevenson, Emma, Nimmo, Myra, Cockburn, Emma, Stevenson, Emma J, Robson-Ansley, Paula, Walshe, Ian, Nimmo, Myra A   +6 more
core  

Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence [PDF]

, 2005
Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses.
Nathan W. Bartlett, Geoffrey L. Smith, Haga, Ismar R, Geraldine Maloney, Bowie, Andrew G., Bartlett, Nathan W., Martina Schröder, Ismar R. Haga, Haga, Ismar R., Patrick C. Reading, Andrew G. Bowie, Fitzgerald, Katherine A, Smith, Geoffrey L, Schroeder, Martina, Reading, Patrick C, Smith, Geoffrey L., Katherine A. Fitzgerald, Bartlett, Nathan W, Julianne Stack, Maloney, Geraldine, Bowie, Andrew G, Schröder, Martina, Reading, Patrick C., Stack, Julianne, Fitzgerald, Katherine A.   +24 more
core   +1 more source