Results 111 to 120 of about 53,340 (302)

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

An association analysis between the variability of the caprine CD36 and CD36-like genes and dairy traits

, 2014
The CD36 molecule plays a key role in the uptake of long-chain fatty acids. In a previous study, we demonstrated that the CD36 gene is duplicated in goats.
González-Redondo, Pedro, Zidi, Ali, Gallardo, David, Serradilla, Juan Manuel, Carrizosa, Juan, Fernández-Cabanás, Víctor M., Polvillo, Oliva, Jordana, Jordi, Urrutia, Baltasar, Amills, Marcel   +9 more
core   +1 more source

Lipoprotein binding preference of CD36 is altered by filipin treatment [PDF]

, 2008
The class B scavenger receptor CD36 binds multiple ligands, including oxidized and native lipoprotein species. CD36 and the related receptor SR-B1 have been localized to caveolae, domains that participate in cell signaling, transcytosis, and regulation ...
Jianshe Zhang, Chu Wuying, Zhang Jianshe, Zhang, Jianshe, Ian Crandall, Chu, Wuying, Crandall, Ian, Crandall Ian, Wuying Chu   +8 more
core   +1 more source

CD36 deletion reduces VLDL secretion, modulates liver prostaglandins, and exacerbates hepatic steatosis in ob/ob mice[S]

Journal of Lipid Research, 2013
Recent findings described the role of CD36-mediated signaling in regulating cellular calcium and the release of various bioactive molecules, including the prostaglandins, neurotransmitters, cholecystokinin, and secretin. Here we document the role of CD36
Fatiha Nassir, Okunade L. Adewole, Elizabeth M. Brunt, Nada A. Abumrad   +3 more
doaj   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Plasma soluble CD36, carotid intima-media thickness and cognitive function in patients with type 2 diabetes

, 2016
Introduction : Diabetes and atherosclerosis are both risk factors of cognitive deficits. Scavenger receptor CD36 is associated with increasing risk of diabetes and atherosclerosis, and may play a role in cognitive deficits.
Bin Zhou, Xiaohui Zhao, Xiaozhen Jiang, Quan Jiang, Ruihua Chen   +4 more
core   +1 more source

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

A Single Nucleotide Insertion in Codon 317 of the CD36 Gene Leads to CD36 Deficiency

, 1996
CD36 is a multifunctional integral-membrane glycoprotein that acts as a receptor for thrombospondin, collagen, long-chain fatty acids, and oxidized LDL. Platelet CD36 deficiency can be divided into two groups.
Tsutomu Nakagawa, Yoshiaki Tomiyama, Yoshiyuki Kurata, Masamichi Shiraga, Yuji Matsuzawa, Satoru Kosugi, Nobuo Nagao, Yuzuru Kanakura, Hirokazu Kashiwagi, Shuichi Nozaki, Shigenori Honda   +10 more
core   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

Role of CD36 in Platelet Function [PDF]

, 2007
CD36 is a scavenger receptor expressed on a wide variety of cells including platelets. It recognizes multiple ligands, yet its function on platelets is incompletely characterized.
Arunima, Ghosh, Ghosh, Arunima
core