Results 91 to 100 of about 53,340 (302)

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Malaria susceptibility and CD36 mutation

Nature, 2000
A critical step in infection by Plasmodium falciparum, the microorganism that causes the most severe form of malaria, is the adhesion of parasitized red blood cells to capillary endothelium. The human protein CD36 is a major receptor for P. falciparum-infected red blood cells1,2 and may contribute to the disease by sequestering infected red blood ...
Aitman, T, Cooper, L, Norsworthy, P, Wahid, F, Gray, J, Curtis, B, McKeigue, P, Kwiatkowski, D, Greenwood, B, Snow, R, Hill, A, Scott, J   +11 more
openaire   +3 more sources

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Sulforaphane attenuates CD36-mediated platelet hyperreactivity through modulating cAMP/PKA/NOX2 signaling in hyperlipidemic conditions

Food Science and Human Wellness
Hyperlipidemia is a risk factor for clinically significant thrombotic events in cardiovascular diseases. Platelet reactivity in hyperlipidemic conditions is enhanced when platelet scavenger receptor CD36 recognizes oxidized lipids in oxidized low-density
Weiqi Li, Chunting Wu, Xinyu Zhou, Xinhui Huang, Chunmei Zhang, Yongjie Ma, Jinqiu Hu, Xiaoyan Bi, Junyu Ma, Mengyao Li, Dong Lu, Liang Hu, Jiahua Fan, Fuli Ya   +13 more
doaj   +1 more source

CD36 in atherosclerosis

Nepalese Heart Journal, 2013
CD36 was described nearly 30 years ago as “glycoprotein IV” the fourth major band of 88KD observed on SDS-PAGE of platelet membrane (1). It is present on many mammalian cell types: microvascular endothelium; professional phagocytes including macrophages, dendritic cells, microglia and retinal pigment-epithellium; erythroid precursors; hepatocytes ...
openaire   +2 more sources

Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early‐Phase Oncology Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović, Ingrid Tomljanović, Wieke H. Grievink, Diana R. Pereira, Michelle Osse, Peter van Balen, Maria J. Juachon, Marieke L. de Kam, Lisa Pagan, Manon A.A. Jansen, Matthijs Moerland, Jacobus J. Bosch   +11 more
wiley   +1 more source

Circulating monocyte partitioning and its alteration in hematological chronic neoplasms

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Circulating monocyte partitioning refers to the relative quantification of the three main monocyte subsets in the peripheral blood, namely classical (cMo), intermediate (iMo), and non‐classical (ncMo) monocytes, as assessed by flow cytometry, a new nomenclature described 15 years ago.
Sihem Tarfi, Dorothée Selimoglu‐Buet, Ivan Sloma, Orianne Wagner‐Ballon, on behalf of the French group CytHem‐LMMC   +4 more
wiley   +1 more source

Erythroid Involvement in CD36 Deficiency [PDF]

Objective. The CD36 molecule is expressed in platelets, monocytes, erythroblasts, and other different tissues. There are 2 types of platelet CD36 deficiency; types I and II, associated with the absence and presence of CD36 on monocytes, respectively.
Watanabe, Kenichi, Aizawa, Yoshifusa, Masuko, Masayoshi, Abo, Toru, Fuse, Ichiro, 4826, 4827, 4828, 4829, Takahashi, Masuhiro, 4831, Miyajima, Seiichi, 4832, 4822, Hanawa, Haruo, Toba, Ken, 4823, Sakaue, Minori, 4824, 4825   +19 more
core  

Coagulation factor FVII fine-tunes hepatic steatosis by blocking AKT-CD36-mediated fatty acid uptake

NAFLD is considered as a risk factor for cardiovascular and cerebrovascular disease owing to its close association with coagulant disturbances. However, the precise biological functions and mechanisms that connect coagulation factors to NAFLD pathology ...
Quanxin Jiang (18003474), Ning Wang (108353), Sijia Lu (566625), Ying Xu (9172), Yanmei Yuan (15255986), Yao Zhang (134381), Xingxing Liang (12643139), Qiqi Qian (18003478), Xuemei Fan (4480078), Jie Xiong (138164), Junli Liu (240401), Junting Xu (1829149), Chuchu Liu (4740894), Suzhen Chen (344588), Peihui Zhou (18003488), Qian Zhou (125859)   +15 more
core   +1 more source

CD36 promotes the epithelial–mesenchymal transition and metastasis in cervical cancer by interacting with TGF-β

Journal of Translational Medicine, 2019
Background Accumulating evidence indicates that CD36 initiates metastasis and correlates with an unfavorable prognosis in cancers. However, there are few reports regarding the roles of CD36 in initiation and metastasis of cervical cancer.
Min Deng, Xiaodong Cai, Ling Long, Linying Xie, Hongmei Ma, Youjian Zhou, Shuguang Liu, Chao Zeng   +7 more
doaj   +1 more source