Results 151 to 160 of about 77,752 (295)

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, Volume 46, Issue 2, Page 352-381, March 2026.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Study on the effect of shikonin on CD36 expression and phagocytic ability of microglia in the isolated cerebral haemorrhage model

Folia Neuropathologica, 2021
Sheng Nie, Jikuang Zhao, Yi Huang, Chenhui Zhou, Fanyong Gong, Fei Zhao   +5 more
doaj   +1 more source

Cd36 knockout mice are protected against lithogenic diet-induced gallstones [PDF]

, 2017
Abumrad, Nada A., Atabai, Kamran, Cifarelli, Vincenza, Clugston, Robin, Davidson, Nicholas O., Kennedy, Susan M., Khalifeh-Soltani, Amin, Newberry, Elizabeth P., Pietka, Terri, Xie, Yan   +9 more
core   +2 more sources

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Krüppel-like factor 2 promotes liver steatosis through upregulation of CD36

, 2013
Jinlian Chen, Xiaojie Lu, Kailin Zou, Kun Ye   +3 more
openalex   +1 more source

CD36 and CD14 immunoreactivity of Reiter cells in inflammatory synovial fluids [PDF]

, 2000
Enrico Selvi, STEFANIA MANGANELLI, RENATO DE STEFANO, ELENA FRATI, ROBERTO MARCOLONGO   +4 more
openalex   +1 more source

Timing of Glucocorticoid Treatment Dictates Glucocorticoid Receptor Actions Modulating the NLRP3‐Inflammasome Activation in Macrophages

The FASEB Journal, Volume 40, Issue 3, 15 February 2026.
Utilizing a clinically relevant course of treatment, our study reveals that glucocorticoids protect against the late NLRP3 inflammasome activation regulating the IL‐1β secretion, the processing of GSDM‐D and pyroptosis following signal 2 stimulation. These potent anti‐inflammatory effects are mediated by the activation of GR signaling and the expansion
David Diaz‐Jimenez, Robert H. Oakley, Jackson A. Hoffman, Carl D. Bortner, Fred Lih, Jianying Li, Jason G. Williams, Erica Scappini, Kevin E. Gerrish, Stavros Garantziotis, Trevor K. Archer, John A. Cidlowski   +11 more
wiley   +1 more source

Discovery and in vitro characterization of a human anti-CD36 scFv

Frontiers in Immunology
IntroductionCD36 is a membrane receptor that participates in the cellular uptake of fatty acids and lipid metabolism. CD36 overexpression favors progression of different pathologies, such as atherosclerosis and cancer.
Cecilia Mata-Cruz, Cecilia Mata-Cruz, Sandra L. Guerrero-Rodríguez, Keyla Gómez-Castellano, Gregorio Carballo-Uicab, Juan Carlos Almagro, Juan Carlos Almagro, S. Mayra Pérez-Tapia, S. Mayra Pérez-Tapia, S. Mayra Pérez-Tapia, Marco A. Velasco-Velázquez   +10 more
doaj   +1 more source

The immune cell landscape in kidneys of patients with lupus nephritis. [PDF]

, 2019
Lupus nephritis is a potentially fatal autoimmune disease for which the current treatment is ineffective and often toxic. To develop mechanistic hypotheses of disease, we analyzed kidney samples from patients with lupus nephritis and from healthy control
Accelerating Medicines Partnership in SLE network, Anolik, Jennifer H, Apruzzese, William, Arazi, Arnon, Berthier, Celine C, Brenner, Michael B, Browne, Edward P, Buyon, Jill P, Chicoine, Adam, Dall'Era, Maria, Davidson, Anne, Diamond, Betty, Eisenhaure, Thomas M, Furie, Richard A, Hacohen, Nir, Hildeman, David A, Hoover, Paul J, Jonsson, A Helena, Kalunian, Kenneth C, Kamen, Diane L, Kretzler, Matthias, Lederer, James A, Li, Shuqiang, Lieb, David J, Liu, Yanyan, Massarotti, Elena, McInnis, Elizabeth A, Noma, Akiko, Nusbaum, Chad, Park, Meyeon, Payan-Schober, Fernanda, Pendergraft, William F, Petri, Michelle A, Putterman, Chaim, Rao, Deepak A, Raychaudhuri, Soumya, Slowikowski, Kamil, Smilek, Dawn E, Steelman, Scott, Sutherby, Danielle, Tosta, Patti, Wofsy, David, Woodle, E Steve, Zhang, Fan   +43 more
core  

Role of microglial and endothelial CD36 in post-ischemic inflammasome activation and interleukin-1β-induced endothelial activation

, 2021
Lidia García‐Bonilla, Rose Sciortino, Ziasmin Shahanoor, Gianfranco Racchumi, Mathangi Janakiraman, Joan Montaner, Ping Zhou, Josef Anrather, Costantino Iadecola   +8 more
openalex   +2 more sources