Radiotherapy and Immune System Interactions Historical Perspectives and Clinical Advancements
ABSTRACT Radiotherapy (RT) has evolved significantly since its inception from treating benign conditions to becoming a cornerstone of cancer treatment. This review examines the complex interactions between RT and the immune system, highlighting its diverse effects on various immune cell populations, and exploring emerging strategies to enhance ...
Safiy Yahia +3 more
wiley +1 more source
Increased expression of CD36 and CD163 in clear cell renal cell carcinoma suggests an association between lipid transport and an "M2-like" macrophage phenotype. [PDF]
Bouraoui Y +11 more
europepmc +1 more source
Gastric Cancer: Pathobiology and Therapeutics
Gastric cancer is a multistep process driven by the interplay of microbial virulence, host epithelial injury, and evolving molecular reprogramming. Initiation involves pathogen‐induced epigenetic alterations and the early subversion of key oncogenic signaling networks, facilitating the transition from chronic injury to metaplasia and malignant ...
Ruixian Yu +16 more
wiley +1 more source
Circulating Liver-Derived and CD36<sup>+</sup> Extracellular Vesicles Correlate With Ectopic Liver Fat and Markers of Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease and Decrease During Weight Loss Intervention. [PDF]
Mellergaard M +9 more
europepmc +1 more source
Effect of the atherogenic index of plasma on the expression of platelet CD36 and CD62P in patients with acute ischemic stroke: a retrospective study from Tianjin, China. [PDF]
Cai Y, Wei M, Gu Y, Wang L, Li X.
europepmc +1 more source
Metabolic Regulation of Immune Responses: Molecular Mechanisms, Diseases, and Therapeutic Targets
FBP1 loss drives immune evasion and therapy resistance by enhancing glycolysis, STAT3 activation, and PD‐L1 expression, leading to T cell exhaustion and NK cell inhibition. FBP1 restoration, via LNP‐mRNA or epigenetic modulation, reverses these immunosuppressive effects, reactivates cytotoxic T cells, promotes M1 macrophage polarization, and enhances ...
Chunwei Li +10 more
wiley +1 more source
Studies of platelet antibodies at MacKay Memorial Hospital in Taiwan: Methods, case reviews and a possible case of post-transfusion purpura. [PDF]
Chen-Yu C +4 more
europepmc +1 more source
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang +22 more
wiley +1 more source
Old Blood, Young Bones: Identification of Middle-Aged Myeloid Cells That Limit Cortical Bone Loss. [PDF]
Koroth J +6 more
europepmc +1 more source
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang +12 more
wiley +1 more source

