Results 41 to 50 of about 81,560 (343)
Association between CD36 and ischemic stroke: consequential or coincidental? [PDF]
Exploration of NeuroscienceCD36 is a transmembrane protein that plays a role in various biological processes, including oxidized low-density lipoprotein and fatty acid uptake as well as regulatory control for inflammation signaling.
Ana-Maria Dobri-Nicoară +5 more
doaj +1 more source
CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis
Nature Communications, 2020 Fatty acids (FAs) are essential nutrients, but how they are transported into cells remains unclear. Here, we show that FAs trigger caveolae-dependent CD36 internalization, which in turn delivers FAs into adipocytes.
Jian-Wei Hao +16 more
semanticscholar +1 more source
Nature Communications, 2021 Acute infection is known to induce rapid expansion of hematopoietic stem cells (HSCs), but the mechanisms supporting this expansion remain incomplete. Using mouse models, we show that inducible CD36 is required for free fatty acid uptake by HSCs during ...
J. Mistry +9 more
semanticscholar +1 more source
Hepatology, EarlyView., 2022 Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan +22 more
wiley +1 more source
Lymphocytes upregulate CD36 in adipose tissue and liver
Adipocyte, 2019 CD36 is a multifunctional scavenger receptor and lipid transporter implicated in metabolic and inflammatory pathologies, as well as cancer progression. CD36 is known to be expressed by adipocytes and monocytes/macrophages, but its expression by T cells ...
Jacob Couturier +15 more
doaj +1 more source
Cell & Bioscience, 2021 Blood–brain barrier (BBB) dysfunction may occur at the onset of Alzheimer’s disease (AD). Pericytes are a vital part of the neurovascular unit and the BBB, acting as gatekeepers of the BBB.
Jianhua Li +9 more
semanticscholar +1 more source
Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis
Hepatology, EarlyView., 2022 EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu +16 more
wiley +1 more source
Microorganisms, 2020 Changes in the erythrocyte membrane induced by Plasmodium falciparum invasion allow cytoadhesion of infected erythrocytes (IEs) to the host endothelium, which can lead to severe complications.
Michael Dörpinghaus +15 more
doaj +1 more source
JUN promotes hypertrophic skin scarring via CD36 in preclinical in vitro and in vivo models
Science Translational Medicine, 2021 Description JUN drives scarring by modifying the roles of fibroblast subpopulations, and JUN antagonism via CD36 may represent an antiscarring therapy. Scar wars Scars developing after skin wound can cause important functional, aesthetic, psychological ...
M. Griffin +26 more
semanticscholar +1 more source
Hepatol CommunCluster of differentiation 36 (CD36) is a transmembrane glycoprotein with the ability to bind to multiple ligands and perform diverse functions. Through the recognition of long-chain fatty acids, proteins containing thrombospondin structural homology repeat domains such as thrombospondin-1, and molecules with molecular structures consistent with danger-
Liu Y, Yin W.
europepmc +2 more sources