CD36: Implications in cardiovascular disease [PDF]
The International Journal of Biochemistry & Cell Biology, 2007 CD36 is a broadly expressed membrane glycoprotein that acts as a facilitator of fatty acid uptake, a signaling molecule, and a receptor for a wide range of ligands, including apoptotic cells, modified forms of low density lipoprotein, thrombospondins, fibrillar beta-amyloid, components of Gram positive bacterial walls and malaria infected erythrocytes.
Maria, Febbraio, Roy L, Silverstein
openaire +2 more sources
Lymphocytes upregulate CD36 in adipose tissue and liver
Adipocyte, 2019 CD36 is a multifunctional scavenger receptor and lipid transporter implicated in metabolic and inflammatory pathologies, as well as cancer progression. CD36 is known to be expressed by adipocytes and monocytes/macrophages, but its expression by T cells ...
Jacob Couturier +15 more
doaj +1 more source
The effects of exogenous lipid on THP-1 cells : an in vitro model of airway aspiration? [PDF]
, 2017 Chronic inflammatory diseases of the airways are associated with gastro-oesophageal reflux (GOR) and aspiration events. The observation of lipid laden macrophages (LLM) within the airway may indicate aspiration secondary to GOR.
Adams +6 more
core +2 more sources
CD36 Deficiency Rescues Lipotoxic Cardiomyopathy [PDF]
Circulation Research, 2007 Obesity-related diabetes mellitus leads to increased myocardial uptake of fatty acids (FAs), resulting in a form of cardiac dysfunction referred to as lipotoxic cardiomyopathy. We have shown previously that chronic activation of the FA-activated nuclear receptor, peroxisome proliferator-activated receptor α (PPARα), is sufficient to drive ...
John, Yang +8 more
openaire +2 more sources
Tumor stem cells fuse with monocytes to form highly invasive tumor-hybrid cells
OncoImmunology, 2020 The ‘cancer cell fusion’ theory is controversial due to the lack of methods available to identify hybrid cells and to follow the phenomenon in patients.
Luis Augusto Aguirre +39 more
doaj +1 more source
Offspring subcutaneous adipose markers are sensitive to the timing of maternal gestational weight gain [PDF]
, 2015 peer-reviewedBackground Excessive maternal weight gain during pregnancy impacts on offspring health. This study focused on the timing of maternal gestational weight gain, using a porcine model with mothers of normal pre-pregnancy weight.
Berry, Donagh +7 more
core +1 more source
MiR-155 has a protective role in the development of non-alcoholic hepatosteatosis in mice [PDF]
, 2013 Hepatic steatosis is a global epidemic that is thought to contribute to the pathogenesis of type 2 diabetes. MicroRNAs (miRs) are regulators that can functionally integrate a range of metabolic and inflammatory pathways in liver.
A Grefhorst +42 more
core +7 more sources
Clearance of apoptotic cells by macrophages induces regulatory phenotype and involves stimulation of cd36 and platelet-activating factor receptor [PDF]
, 2013 Phagocytosis of apoptotic cells (efferocytosis) induces macrophage differentiation towards a regulatory phenotype (IL-10high/IL-12p40low). CD36 is involved in the recognition of apoptotic cells (AC), and we have shown that the platelet-activating factor ...
Ferracini, M. +3 more
core +2 more sources
Prediction of B cell epitopes of CD36 and preparation of MAP
Zhongguo shuxue zazhiObjective To analyze the structure of CD36, search the possible B cell epitopes and prepare multi-antigen peptides(MAP) with B cell epitopes, so as to provide a preliminary experimental basis for the preparation of CD36 antibodies using MAP with B cell ...
Jing LIU +7 more
doaj +1 more source
MicroRNA—A Tumor Trojan Horse for Tumor-Associated Macrophages
Cells, 2019 MicroRNAs (miRs) significantly contribute to the regulation of gene expression, by virtue of their ability to interact with a broad, yet specific set of target genes.
Shahzad Nawaz Syed +3 more
doaj +1 more source