Results 21 to 30 of about 42,741 (260)

GLP-1(7-36) inhibits atherosclerosis progression in ApoE-/- mouse aorta by lowering expressions of CD36 and ACAT1 in foam cells

Di-san junyi daxue xuebao, 2019
Objective To investigate whether glucagon-like peptide-1 (GLP-1) (7-36) inhibits the progression of aortic atherosclerotic plaque in ApoE knockout (ApoE-/-) mice fed with high-fat diet and the effect of GLP-1 (7-36) on the expressions of CD36 and acyl ...
HAN Yongkui, YUE Yunfei, ZHANG Kui, SHEN Xiaoyu   +3 more
doaj   +1 more source

Interaction between CD36 and FABP4 modulates adipocyte-induced fatty acid import and metabolism in breast cancer

npj Breast Cancer, 2021
Adipocytes influence breast cancer behaviour via fatty acid release into the tumour microenvironment. Co-culturing human adipocytes and breast cancer cells increased CD36 expression, with fatty acid import into breast cancer cells.
Jones Gyamfi, Joo Hye Yeo, Doru Kwon, Byung Soh Min, Yoon Jin Cha, Ja Seung Koo, Joon Jeong, Jinu Lee, Junjeong Choi   +8 more
doaj   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

DPP-4 Inhibitor Linagliptin Ameliorates Oxidized LDL-Induced THP-1 Macrophage Foam Cell Formation and Inflammation

Drug Design, Development and Therapy, 2020
Haoran Wang,1 Yue Li,2 Xiaoliang Zhang,2 Zhonglin Xu,2 Jianzhong Zhou,3 Wei Shang2 1Department of Endocrinology, The Ninth People’s Hospital of Chongqing, Chongqing 400700, People’s Republic of China; 2Department of Cardiology, The Ninth ...
Wang H, Li Y, Zhang X, Xu Z, Zhou J, Shang W   +5 more
doaj  

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

CD36 deficiency affects depressive-like behaviors possibly by modifying gut microbiota and the inflammasome pathway in mice

Translational Psychiatry, 2021
Both inflammatory processes and gut microbiota have been implicated in the pathophysiology of depressive disorders. The class B scavenger receptor CD36 is involved in the cytotoxicity associated with inflammation.
Shunjie Bai, Wei Wang, Ting Wang, Juan Li, Shuxiao Zhang, Zhi Chen, Xunzhong Qi, Jianjun Chen, Ke Cheng, Peng Xie   +9 more
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Effects of different long-chain fatty acids on lipid uptake and CD36 palmitoylation in small intestinal epithelial cells of mouse

Huanan Nongye Daxue xuebao
ObjectiveTo investigate the impacts of various long-chain fatty acids on fatty acid uptake and the palmitoylation of cluster of differentiation 36 (CD36) in mouse small intestinal epithelial cells.MethodIn vitro, ModeK, the mouse intestinal epithelial ...
Lilin CAI, Junfeng WANG, Xiaolei YU, Yue ZHANG, Gang SHU, Lina WANG, Qingyan JIANG, Songbo WANG   +7 more
doaj   +1 more source

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

Advanced Science, EarlyView.
Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen, Qimeng Wang, Ke Yang, Qinghai Lian, Xuyun Peng, Zhiyong Gong, Xinyi Zhao, Yong Wu, Tian Tao, Siqi Xu, Yifan Chen, Xiaoyan Tang, Jinghui Guo, Geyang Xu, Qi Zhang   +14 more
wiley   +1 more source

CD36-mediated podocyte lipotoxicity promotes foot process effacement

Open Medicine
Lipid metabolism disorders lead to lipotoxicity. The hyperlipidemia-induced early stage of renal injury mainly manifests as podocyte damage. CD36 mediates fatty acid uptake and the subsequent accumulation of toxic lipid metabolites, resulting in podocyte
Hua Wei, Peng Lan, Chen Xue-mei, Jiang XuShun, Hu JianGuo, Jiang Xian-Hong, Xiang Xu, Wan Jiangmin, Long Yingfei, Xiong Jianqiong, Ma Xueyi, Du Xiaogang   +11 more
doaj   +1 more source