Results 41 to 50 of about 53,340 (302)

Spontaneous Bacterial Keratitis in CD36 Knockout Mice [PDF]

, 2017
Purpose: CD36 is a Class B scavenger receptor that is constitutively expressed in the corneal epithelium and has been implicated in many homeostatic functions, including the homeostasis of the epidermal barrier.
Heimer, Susan, Ksander, Bruce, Gregory-Ksander, Meredith, Klocke, Julia, Barcia, Rita N., Gilmore, Michael, Zieske, James, Cario, Elke   +7 more
core   +1 more source

Effects of different long-chain fatty acids on lipid uptake and CD36 palmitoylation in small intestinal epithelial cells of mouse

Huanan Nongye Daxue xuebao
ObjectiveTo investigate the impacts of various long-chain fatty acids on fatty acid uptake and the palmitoylation of cluster of differentiation 36 (CD36) in mouse small intestinal epithelial cells.MethodIn vitro, ModeK, the mouse intestinal epithelial ...
Lilin CAI, Junfeng WANG, Xiaolei YU, Yue ZHANG, Gang SHU, Lina WANG, Qingyan JIANG, Songbo WANG   +7 more
doaj   +1 more source

CD36 deficiency affects depressive-like behaviors possibly by modifying gut microbiota and the inflammasome pathway in mice

Translational Psychiatry, 2021
Both inflammatory processes and gut microbiota have been implicated in the pathophysiology of depressive disorders. The class B scavenger receptor CD36 is involved in the cytotoxicity associated with inflammation.
Shunjie Bai, Wei Wang, Ting Wang, Juan Li, Shuxiao Zhang, Zhi Chen, Xunzhong Qi, Jianjun Chen, Ke Cheng, Peng Xie   +9 more
doaj   +1 more source

Biomimetic Macrophage Cell Membrane‐Based Nanoparticles for Effective Treatment of Glioblastoma Through Boron Neutron Capture Therapy Combined With Immunotherapy

Advanced Science, EarlyView.
ABSTRACT Glioblastoma multiforme (GBM) remains largely incurable due to the blood‐brain barrier (BBB) and immunosuppressive microenvironment. While boron neutron capture therapy (BNCT) selectively eradicates tumor cells via 10B(n, α)‐7Li reactions, its clinical potential in GBM is unrealized because of the suboptimal pharmacokinetics of conventional ...
Jiawen Chen, Haoyu You, Hefa Huang, Huihui Chai, Ruize Zhu, Yun Guan, Qisheng Tang, Tianwen Li, Shan Jiang, Houshi Xu, Peng Wang, Yue Wang, Maoyuan Sun, Beining Liu, Zhen Li, Yulai Zeng, Weiqiu Ping, Yanlin Teng, Songlin Yan, Qinghui Li, Long Gu, Tao Sun, Zhifeng Shi   +22 more
wiley   +1 more source

CD36-mediated podocyte lipotoxicity promotes foot process effacement

Open Medicine
Lipid metabolism disorders lead to lipotoxicity. The hyperlipidemia-induced early stage of renal injury mainly manifests as podocyte damage. CD36 mediates fatty acid uptake and the subsequent accumulation of toxic lipid metabolites, resulting in podocyte
Hua Wei, Peng Lan, Chen Xue-mei, Jiang XuShun, Hu JianGuo, Jiang Xian-Hong, Xiang Xu, Wan Jiangmin, Long Yingfei, Xiong Jianqiong, Ma Xueyi, Du Xiaogang   +11 more
doaj   +1 more source

Role of CD36 in cancer progression, stemness, and targeting

Frontiers in Cell and Developmental Biology, 2022
CD36 is highly expressed in diverse tumor types and its expression correlates with advanced stages, poor prognosis, and reduced survival. In cancer cells, CD36: 1) increases fatty acid uptake, reprogramming lipid metabolism; 2) favors cancer cell ...
Sandra L. Guerrero-Rodríguez, Cecilia Mata-Cruz, Cecilia Mata-Cruz, Sonia M. Pérez-Tapia, Sonia M. Pérez-Tapia, Sonia M. Pérez-Tapia, Marco A. Velasco-Velázquez   +6 more
doaj   +1 more source

CD36 in liver diseases

Hepatology Communications
Cluster of differentiation 36 (CD36) is a transmembrane glycoprotein with the ability to bind to multiple ligands and perform diverse functions. Through the recognition of long-chain fatty acids, proteins containing thrombospondin structural homology repeat domains such as thrombospondin-1, and molecules with molecular structures consistent with danger-
Yi Liu, Wenwei Yin
openaire   +2 more sources

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, EarlyView.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

Cytoadherence and virulence - the case of Plasmodium knowlesi malaria. [PDF]

, 2012
BACKGROUND: Cytoadherence of infected red blood cells to brain endothelium is causally implicated in malarial coma, one of the severe manifestations of falciparum malaria.
Cox-Singh, J, Craig, Alister G., Lu Woon, Alister G Craig, Farrah A Fatih, Woon, Lu Chan, Siner, Angela, Singh Balbir, Cox-Singh, Janet, Siner Angela, Fatih, FA, Singh, Balbir, Janet Cox-Singh, Singh, B, Balbir Singh, Fatih, Farrah A., Cox-Singh Janet, Krishna Sanjeev, Ahmed, Atique, Siner, A, Angela Siner, Cox Singh, Janet, Ahmed Atique, Craig Alister G, Woon, LC, Woon Lu, Krishna, S, Fatih Farrah A, Sanjeev Krishna, Craig, AG, Krishna, Sanjeev, Ahmed, A, Craig, Alister, Atique Ahmed, Lu Chan Woon, Balbir, Singh, Craig, Alister G, Lu, Chan Woon, Sanjeev, Krishna, Cox-Singh, J., Atique M, Ahmed, Farrah, A Fatih   +41 more
core   +1 more source

Study on CD36 gene expression in megakaryocytic lineage derived from umbilical cord blood hematopoietic stem cells cultured in vitro

Zhongguo shuxue zazhi
[Objective] To elucidate the expression level and transcript structure of the CD36 gene in megakaryocytes cultured in vitro. [Methods] Using umbilical cord blood CD34+ hematopoietic stem cells as the starting point, megakaryocytic lineage cells were ...
XU Fang, YU Guangshu, LING Xia, HE Ji, XU Xianguo   +4 more
doaj   +1 more source