Results 51 to 60 of about 77,752 (295)

Role of Esrrg in the Fibrate-Mediated Regulation of Lipid Metabolism Genes in Human ApoA-I Transgenic Mice [PDF]

, 2009
We have used a new ApoA-I transgenic mouse model to identify by global gene expression profiling, candidate genes that affect lipid and lipoprotein metabolism in response to fenofibrate treatment.
A Chroni, A Duka, A Patsialou, A Rigotti, A Walsh, AP Feinberg, B Staels, B Staels, B Staels, B Staels, B Staels, B Staels, BN Finck, CW Miller, D Arsenijevic, D Lan, D Sanoudou, D Sanoudou, D Sanoudou, EM Rubin, ES Cathcart, F Yadetie, G Fredrikson, G Martin, H Duez, H Samyn, HB Rubins, HY Kan, J Karbowska, J Lin, J St Pierre, JC Fruchart, JD Brunzell, JJ Lehman, JK Reddy, JL Goldstein, JM Huss, JM Huss, JP Desager, K C Hayes, K Drosatos, K Motojima, K Schoonjans, K Schoonjans, KE Kypreos, KE Kypreos, KS Frederiksen, L Berthou, LA Pennacchio, LJ Kelly, M Bouly, MB Eisen, MC Hunt, MJ Holness, N Hennuyer, N Vu-Dac, N Vu-Dac, N Vu-Dac, N Vu-Dac, NF Cariello, P Puigserver, Q Guo, R Sladek, RB Vega, RL Jacobs, SA Greenberg, SN Schreiber, V Beisvag, V Giguere, V I Zannis, V Litvak, VG Tusher, VI Zannis, VI Zannis, VI Zannis, WC Roberts, X Prieur, Y Kamei, Y Nagai, Z Wu   +79 more
core   +3 more sources

XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan, Yuhua Zhang, Jiawei Du, Yongjun Zhu, Wei Cao, Yongjie Wei, Han Wu, Shiyu Qiu, Shiyi Pan, Lian Chen, Pingping Liang, Renjie Chai, Jianming Yang, Qiaojun Fang   +13 more
wiley   +1 more source

Study on CD36 gene expression in megakaryocytic lineage derived from umbilical cord blood hematopoietic stem cells cultured in vitro

Zhongguo shuxue zazhi
[Objective] To elucidate the expression level and transcript structure of the CD36 gene in megakaryocytes cultured in vitro. [Methods] Using umbilical cord blood CD34+ hematopoietic stem cells as the starting point, megakaryocytic lineage cells were ...
XU Fang, YU Guangshu, LING Xia, HE Ji, XU Xianguo   +4 more
doaj   +1 more source

B Cell Activation in Insulin Resistance and Obesity [PDF]

, 2011
Our group has demonstrated that inflammatory diseases such as type 2 diabetes (DM), inflammatory bowel disease (IBD), and periodontal disease (PD) are associated with altered B cell function that may contribute to disease pathogenesis. B cells were found
Apovian, Caroline, Ganley-Leal, Lisa, Gokce, Noyan, Liang, YanMei, McDonnell, Marie, Mehta, Ankeeta, Zhang, Jeanette   +6 more
core   +1 more source

Regulation of tissue crosstalk by skeletal muscle-derived myonectin and other myokines. [PDF]

, 2012
The integrated control of animal physiology requires intimate tissue crosstalk, a vital task mediated by circulating humoral factors. As one type of these factors, adipose tissue-derived adipokines have recently garnered attention as important regulators
Seldin, Marcus M, Wong, G William
core   +1 more source

HMGB2–RAD21 Axis Promotes Fibro/Adipogenic Progenitor Proliferation and Regulates Fat Infiltration

Advanced Science, EarlyView.
This study constructed the first developmental atlas of embryonic skeletal muscle fibro/adipogenic progenitors (FAPs) and identified an HMGB2+ FAPs subpopulation that regulates FAP pool size and muscle homeostasis. HMGB2 directly targets the RAD21 promoter, and its knockout significantly reduces FAP numbers, thereby lowering the potential for ...
Xian Tong, Ziyun Liang, Tianqi Duo, Liping Pan, Qi Zhu, Jiete Liang, Xianyao Luo, Qingcai Feng, Rong Xu, Yihao Liu, Xu Chen, Luxi Chen, Xiaohong Liu, Yaosheng Chen, Delin Mo   +14 more
wiley   +1 more source

CD36-mediated immune response and transfusion safety

Zhongguo shuxue zazhi
Cluster of differentiation 36 (CD36) is a highly glycosylated double transmembrane glycoprotein, which is involved in the inflammatory response and immune regulation of the body.
JIE Xiaomei, HE Ziyi, HU Yingming, BEI Menghui   +3 more
doaj   +1 more source

Macrophage-derived upd3 Cytokine causes impaired glucose homeostasis and reduced lifespan in drosophila fed a lipid-rich diet [PDF]

, 2014
Long-term consumption of fatty foods is associated with obesity, macrophage activation and inflammation, metabolic imbalance, and a reduced lifespan. We took advantage of Drosophila genetics to investigate the role of macrophages and the pathway(s) that ...
Dionne, MS, Geissmann, F, Kierdorf, K, Pouchelon, CA, Vivancos, V, Woodcock, KJ   +5 more
core   +1 more source

Changes of Taste, Smell and Eating Behavior in Patients Undergoing Bariatric Surgery: Associations with PROP Phenotypes and Polymorphisms in the Odorant-Binding Protein OBPIIa and CD36 Receptor Genes [PDF]

, 2021
Melania Melis, Stefano Pintus, Mariano Mastinu, Giovanni Fantola, Roberto Moroni, Marta Yanina Pepino, Iole Tomassini Barbarossa   +6 more
openalex   +1 more source

Targeting the CMKLR1‐Mediated Signaling Rebalances Immunometabolism State in Middle‐Age Testicular Macrophages

Advanced Science, EarlyView.
In middle age, testicular CMKLR1⁺ macrophages exhibited a pro‐inflammatory immunometabolic profile, mediated by adipose signals associated with high BMI. However, inhibition of CMKLR1 signaling, either through Cmklr1 genetic ablation or treatment with a CMKLR1 antagonist peptide, can reverse this phenotype.
Zhendong Zhu, Feifei Du, Yang Liu, Jinchunzi Yang, Lei Ge, Tianxia Xiao, Mengxia Li, Jie Chen, Jia Tang, Yali Yang, Jian V. Zhang   +10 more
wiley   +1 more source