Results 171 to 180 of about 67,119 (304)

Mitochondrial transfer in acute myeloid leukaemia and multiple myeloma: Mechanisms, consequences and potential therapeutic opportunities

The FEBS Journal, EarlyView.
Mitochondria can be transferred from bone marrow cells to cancer cells in acute myeloid leukaemia and multiple myeloma, boosting tumour energy production, growth, and drug resistance. This review highlights key transfer mechanisms and shows how targeting mitochondrial movement and dynamics may offer new therapeutic strategies to limit cancer ...
Ebubechukwu Nwarunma, Mark T. S. Williams   +1 more
wiley   +1 more source

Changes of B cell subsets characterized with CD27 and CD38 phenotypes in peripheral blood of myasthenia gravis patients

Chinese Journal of Contemporary Neurology and Neurosurgery, 2019
Objective To investigate the clinical significance of peripheral B-cell subsets with CD27 and CD38 phenotypes in myasthenia gravis (MG) patients. Methods Peripheral blood samples of 43 MG patients and 38 health controls (HC) from January 2016 to Decamber
Jian⁃hua JIANG, Qun XUE, Cui⁃ping LIU, Qi FANG, Li⁃qiang YU, Lu⁃lu ZHANG, Jue⁃an JIANG   +6 more
doaj  

Understanding and addressing resistance to IMiDs immunomodulatory compounds in multiple myeloma

The FEBS Journal, EarlyView.
IMiDs are pivotal in the treatment of multiple myeloma. Mechanisms of resistance comprise cell intrinsic and extrinsic pathways, involving tumour microenvironment, immune cell dysfunction, CRBN‐dependent and independent genetic drivers and epigenetic changes.
Maria‐Cynthia Fuentes‐Lacouture, Devi Nandana, Karthik Ramasamy, Anjan Thakurta   +3 more
wiley   +1 more source

CD38+ NK cells: novel players in immunoregulation. [PDF]

Front Immunol
Chang X, Fang K.
europepmc   +1 more source

High‐Dimensional Immune Profiling Identifies Circulating NKT‐Like Cells Associated With Severity Outcome in Acute Pancreatitis at Disease Onset

Immunology, EarlyView.
High‐dimensional spectral cytometry of peripheral blood mononuclear cells at hospital admission revealed that acute pancreatitis patients who subsequently developed moderately‐to‐severe disease exhibited a specific reduction of circulating CD2 + CD8dim NKT‐like cells, which appear to acquire an altered cytotoxic‐like phenotype upon IL‐15 stimulation ...
Carolina González de Castro, Mª. Lourdes Ruiz Rebollo, Paloma Cal‐Sabater, Elisa Arribas‐Rodríguez, Álvaro Martín‐Muñoz, Alejandro Gonzalez del Hierro, Marina Perez Mazzali, Jessica Matesanz‐Isabel, Hugo Gonzalo‐Benito, Sara Cuesta‐Sancho, David Bernardo   +10 more
wiley   +1 more source

Antibody M-19 distinguishes intracellular and extracellular CD38

, 2013
CD38 is an enzyme capable of synthesizing two second messengers, cyclic ADP ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP). Generally, CD38 is considered as a Type II membrane protein, which means the catalytic active domain ...
Wang, X, Zhao, Y, Lee, HC
core  

Loss of CD38 antigen on CD34+CD38+ cells during short-term culture [PDF]

Leukemia, 2000
D, von Laer, A, Corovic, B, Vogt, B, Fehse, S, Roscher, A, Rimek, C, Baum, W, Ostertag   +7 more
openaire   +2 more sources

CD38 enzymatic activity regulates LT-HSC exit from quiescence.

(A) Single CD38- and CD38+ LT-HSCs were sorted and cultured in liquid media with or without 78c, a CD38 inhibitor. (B) Frequency of LT-HSCs that had completed the first division during incubation time is presented (3 independent experiments).
Anupam Sinha (1974100), Andreas Dahl (2696749), Tatyana Grinenko (18078786), Malte von Bonin (400911), Juan Alberto Pérez-Valencia (18078780), Sema Elif Eski (10899813), Manja Wobus (326146), Liliia Ibneeva (18078774), Susanne Reinhardt (7824746), Martin Bornhäuser (219605), Sumeet Pal Singh (10899822), Alexander Gerbaulet (558872), Iryna Kovtun (18078777), Ben Wielockx (13181916), Jaime Sancho (329189), Marc Schmitz (357415), Rebekka Wehner (357414), Frances Lund (18078783), Triantafyllos Chavakis (5816888), Luise Rupp (15167618)   +19 more
core   +1 more source

Long‐Acting Cabotegravir/Rilpivirine Reduces Immune‐Activation and ‐Senescence in People With HIV With CMV Co‐Infection

Immunology, EarlyView.
This study investigates the impact of switching to long‐acting (LA) injectable cabotegravir and rilpivirine (CAB/RPV‐LA) on immune‐activation and ‐senescence in people with HIV (PWH). Thirty‐seven PWH switching to CAB/RPV‐LA and nine continuing oral ART were analysed over 72 weeks. LA therapy led to significant reductions in activation T and senescence
Mariasilvia Guardiani, Eeva Tortellini, Anna Carraro, Maria Antonella Zingaropoli, Lorenzo Ansaldo, Alessandra Grimaldi, Serena Vita, Federica Dominelli, Fabio Mengoni, Caterina Pasquazzi, Ombretta Turriziani, Maria Rosa Ciardi, Vincenzo Vullo, Claudio Maria Mastroianni, Raffaella Marocco, Cosmo Del Borgo, Miriam Lichtner   +16 more
wiley   +1 more source

Structural dissection of CD38 antigen engagement by CAR binders and rational affinity tuning. [PDF]

iScience
Cheng Z, Zhang L, Liang Z, Huang Q, Tang Z, Shi X, Liu L, Yang G, Yan L.   +8 more
europepmc   +1 more source