The role of 67 kDa laminin receptor in G-CSF-induced hematopoietic stem cell mobilization [PDF]
, 2007 Visconte, Valeria
core +1 more source
Quantification of SARM1 NADase Activity in Human Peripheral Blood Mononuclear Cells
The FASEB Journal, Volume 40, Issue 9, 15 May 2026.Proposed model for NAD+ metabolism in (A) control and (B) SARM1 activated PBMCs. In native form, 3‐AP and Vacor compete with NAM as an alternative substrate for NAMPT. This consequently decreases generation of NMN and biosynthesis of NAD+ is limited by both a reduction in precursor NMN and direct inhibition of NMNAT by Vacor‐MN and 3‐AP‐MN.
Lila F. Dabill +5 more
wiley +1 more source
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, Volume 16, Issue 5, Page 857-869, May 2026.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
Rapid Discovery of CD38 Inhibitor via DNA-Encoded Natural Product Library Screening. [PDF]
MoleculesShi X, Liang Z, Meng W, Yang G, Yan L.
europepmc +1 more source
Advanced Science, Volume 13, Issue 26, 8 May 2026.This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang +13 more
wiley +1 more source
Resolving the renal microenvironment: a 5-plex immunofluorescence workflow to quantify B-lineage cells in FFPE lupus nephritis biopsies. [PDF]
Front ImmunolChan C +5 more
europepmc +1 more source
NAD+‒circadian rhythm coupling in dementia
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract The circadian rhythm system and sleep coordinate whole‐body functions across the 24‐h cycle, yet these rhythms progressively deteriorate with neurodegenerative diseases, including dementia. Growing evidence indicates that nicotinamide adenine dinucleotide (NAD+) interacts with the circadian system through multiple molecular pathways and that ...
Shi‐qi Zhang +7 more
wiley +1 more source
Association between CD56, CD38 and chronic endometritis and analysis of pregnancy prognosis: a single-center retrospective cohort study. [PDF]
Front Med (Lausanne)Kong Y, Zhou S, Zhou Q.
europepmc +1 more source
Abi3S212F Alzheimer's disease variant alters plaque structure and disrupts microglia
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract BACKGROUND Genetic variants affecting microglial function can influence Alzheimer's disease (AD) risk, yet the underlying mechanisms remain unclear. The AD‐associated ABI3S209F (Abi3S212F in mouse) variant regulates cytoskeletal dynamics, but its in vivo impact on pathology is unknown. METHODS: An Abi3S212F mouse was developed and crossed with
Claire A. Butler +29 more
wiley +1 more source
Novel Roles for the Ectoenzyme CD38 in the Maintenance of Transcriptional and Metabolic Homeostasis in Astrocytes. [PDF]
GliaBasak S +15 more
europepmc +1 more source