Results 181 to 190 of about 92,020 (286)

Confined B‐Cell Reconstruction and High T‐Cell Clonality Define Clinical Response to Cladribine Treatment

Annals of Neurology, Volume 99, Issue 5, Page 1166-1172, May 2026.
Cladribine tablets are approved for relapsing multiple sclerosis, mediating their clinical effect by moderately depleting lymphocytes. In a prospective, monocentric study including 22 patients completing 2 annual cycles of cladribine, B‐ and T‐cell receptor repertoires and relapse activity were assessed at baseline and after 24 months. T‐cell clonality
Tilman Schneider‐Hohendorf, Maria Eveslage, Timo Wirth, Christian Wünsch, Eva M. Schumann, Jan D. Lünemann, Heinz Wiendl, Luisa Klotz, Nicholas Schwab   +8 more
wiley   +1 more source

Regulating the regulators via targeting CD38 in the tumor microenvironment. [PDF]

Front Immunol
Dutta N, Halder N, Chini EN, Kim S, Manna A.   +4 more
europepmc   +1 more source

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP): A Comprehensive Review of Types, Pathophysiology, and Treatment Approaches

Brain and Behavior, Volume 16, Issue 5, May 2026.
Chronic inflammatory demyelinating polyneuropathy is an autoimmune disorder causing demyelination, leading to distal weakness, sensory loss, and autonomic dysfunction. Immune activation triggers macrophage‐mediated myelin damage and conduction failure.
Ayesha Khan, Arsal Khan, Kuldeep Dalpat Rai, Anzel Saeed, Harsh Kumar, Aneesh Kumar Sangtiani, Tehreem Fatima, Muhammad Tanveer Alam, Faiza Rajput, Sakshi Chawla, Hussain Haider Shah, Humaira Kalam   +11 more
wiley   +1 more source

CD38 degrades MAVS through mitophagy to inhibit type I interferon secretion in nasopharyngeal carcinoma cells and impairs CD8⁺T cell-mediated anti-tumor immunity. [PDF]

Nat Commun
Liang L, Li W, Liu S, He Q, Zeng F, Cao J, Lei Y, Li Y, Zhou Y.   +8 more
europepmc   +1 more source

FGF23 and Immune Cell Signatures Causally Linked to Subarachnoid Hemorrhage: Evidence From Multi‐Omics and Genetic Colocalization

Brain and Behavior, Volume 16, Issue 5, May 2026.
Causal links identified between five inflammatory proteins, 22 immune cell types, and subarachnoid hemorrhage (SAH) via Mendelian randomization. Multi‐omics integration (pQTL, eQTL) revealed regulatory mechanisms underlying inflammation in SAH. FGF23 and CD4 Tregs emerged as key therapeutic targets, supported by colocalization and replication analysis.
Xingjie Shi, Cheng Zhang, Tao Yang, Zhiming Sun, Chao Wang, Lucheng Zhou, Shiqiang Hou, Ning Lin, Lanlan Zhang   +8 more
wiley   +1 more source

Efficacy and Safety of Anti-CD38 Antibody-Containing Triplet Regimens in Frail Patients with Multiple Myeloma. [PDF]

Cancers (Basel)
Iriuchishima H, Saito A, Mihara M, Kanaya S, Yoshizawa R, Isoda A, Matsumoto M.   +6 more
europepmc   +1 more source

When Timing Matters Most: Early Relapse Outweighs Baseline Risk in Myeloma

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Multiple myeloma outcomes vary widely, with risk stratification typically based on baseline characteristics. Functionally high‐risk multiple myeloma (FHRMM), defined by early relapse within 12 months of initial therapy or autologous stem cell transplant, is associated with poor prognosis.
Xinhe Shan, Sandra P. Susanibar‐Adaniya   +1 more
wiley   +1 more source

Circulating exhausted CD8+ effector memory cells differentiate immune checkpoint inhibitor-induced liver injury from other acute immune-mediated liver injuries. [PDF]

J Immunother Cancer
Astbury S, Atallah E, Grove JI, Bozward AG, Davies SP, Sheehan MJ, Kumpf SW, Qian J, Krajewska NM, Wootton GE, Lingaya MR, Kresnik D, Radulescu F, Rao A, Franks H, Ruiz-Ortega L, Riveiro-Barciela M, Ramaiah SK, Lanz TA, Ji C, Patel PM, Oo YH, Aithal GP.   +22 more
europepmc   +1 more source

Enhanced Fc and complement activity of Fc‐modified avelumab boosts anti‐tumor activity but promotes NK cell fratricide

Clinical &Translational Immunology, Volume 15, Issue 5, 2026.
Abstract Objectives The anti‐PD‐L1 antibody avelumab has demonstrated efficacy across multiple cancer types. Avelumab primarily blocks the PD‐1/L1 immune checkpoint, while inducing antibody‐dependent cellular cytotoxicity (ADCC) from CD16a+ NK cells.
Lachlan J Dobson, Barry D Hock, Ariana HT Drabble, Liping Goddard, Judith L McKenzie, Sean A MacPherson, Alexander D McLellan   +6 more
wiley   +1 more source

CD38 expression by neonatal human naive CD4+ T cells shapes their distinct metabolic and tolerogenic properties. [PDF]

J Clin Invest
Dwyer LR, DeRogatis AM, Clancy S, Gouirand V, Chien C, Rogers EE, Oltman SP, Jelliffe-Pawlowski LL, van den Broek T, van Wijk F, Lynch SV, Rutishauser RL, Wagner A, Combes AJ, Scharschmidt TC.   +14 more
europepmc   +1 more source