Results 21 to 30 of about 575,189 (264)

Comparative Analysis of Conformational Dynamics and Systematic Characterization of Cryptic Pockets in the SARS-CoV-2 Omicron BA.2, BA.2.75 and XBB.1 Spike Complexes with the ACE2 Host Receptor: Confluence of Binding and Structural Plasticity in Mediating Networks of Conserved Allosteric Sites

Viruses, 2023
In the current study, we explore coarse-grained simulations and atomistic molecular dynamics together with binding energetics scanning and cryptic pocket detection in a comparative examination of conformational landscapes and systematic characterization ...
Mohammed Alshahrani, Grace Gupta, Sian Xiao, Peng Tao, Gennady Verkhivker   +4 more
doaj   +1 more source

Modulation of CD4 by suramin [PDF]

Clinical and Experimental Immunology, 1993
SUMMARYSuramin is a polysulphonated compound which can selectively bind to, and inhibit the activity of, a wide range of growth factors. There has been renewed interest recently in suramin as an anti-cancer agent and therefore we have studied its effects on lymphocyte subset populations and recombinant human IL-2 (rhIL-2) activation on lymphocytes in ...
P D, Allen, D H, Johnston, M G, Macey, N S, Williams, A C, Newland   +4 more
openaire   +2 more sources

Analysis Activity of Elephantopus scaber Leaves Extract Against Quantitative Changes of Lymphocytes Cells in BALB/c Mice After Induction of DMBA and Estrogen

Journal of Experimental Life Science, 2019
The carcinogenic compounds such as DMBA known for having the ability to promote the DNA damage that affects the growth regulator genes. Therefore, uncontrolled cell growth will occur and change the immune system. Elephantopus scaber extract is considered
Lailiyavina Rochmatika, Sri Widyarti, Muhammad Sasmito Djati   +2 more
doaj   +1 more source

Comparing the Efficacy of Chemical Cautery to Cryosurgery on CD4+ Status of HIV Patients with Condyloma Acuminata

Clinical, Cosmetic and Investigational Dermatology, 2021
Prasetyadi Mawardi,1 Bobby Febrianto,1 Danu Yuliarto,1 Tatar Sumandjar2 1Department of Dermatology and Venereology, Faculty of Medicine, Sebelas Maret University/Dr. Moewardi General Hospital, Surakarta, Central Java, Indonesia; 2Voluntary Counseling and
Mawardi P, Febrianto B, Yuliarto D, Sumandjar T   +3 more
doaj  

Tapak liman (Elephantopus scaber L) Extract Induced CD4+ and CD8+ Differentiation from Hematopoietic Stem Cell/Progenitor Cell Proliferation of Mice (Mus musculus)

Journal of Experimental Life Science, 2015
Tapak liman (Elephantopus scaber L) is one of the traditional medicinal plants, which are containing several active compounds that potentially affecting hematopoietic.
M. Sasmito Djati, Hindun Habibu, Nabilah A Jatiatmaja, Muhaimin Rifa'i   +3 more
doaj   +1 more source

Pan-cancer landscape of aberrant DNA Methylation across childhood Cancers: Molecular Characteristics and Clinical relevance

Experimental Hematology & Oncology, 2022
Aberrant DNA methylation (DNAm) is an important epigenetic regulator in various cancers. Pan-cancer DNAm analyses have investigated the potential common mechanisms of DNAm in tumorigenesis.
Zheng Dong, Hongyu Zhou
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

The treatment dynamics assessment among patients with chronic viral hepatitis B, infected with human immunodeficiency virus

Journal of Education, Health and Sport, 2020
Introduction: the article represents prospective study results of the treatment dynamics among patients with chronic viral hepatitis B, infected with human immunodeficiency virus.
L. V. Moroz, T. O. Melnyk
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Estrogen and progesterone attenuate CD4-positive immune cell traffic to the penumbra region of rat’s ischemic stroke brain [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Stroke is an acute cerebrovascular disease with a high incidence, high disability rate, and high mortality. Stroke damages the integrity of the blood-brain barrier.
Aboutaleb Tamtaji, Sayyed Alireza Talaei, Homayoun Naderian, Mohammad Ali Atlasi, Nasim Alipour, Abolfazl Azami-Tameh   +5 more
doaj   +1 more source