Results 211 to 220 of about 576,584 (261)
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The Journal of Immunology, 1994
Abstract Anti-CD4 has been extensively studied in murine models of autoimmunity and transplantation. The timing of anti-CD4 administration in these systems is critical because anti-CD4 effectively blocks primary T-dependent responses but does not diminish ongoing or memory responses in immunized animals.
J H, Chace, J S, Cowdery, E H, Field
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Abstract Anti-CD4 has been extensively studied in murine models of autoimmunity and transplantation. The timing of anti-CD4 administration in these systems is critical because anti-CD4 effectively blocks primary T-dependent responses but does not diminish ongoing or memory responses in immunized animals.
J H, Chace, J S, Cowdery, E H, Field
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Evaluation of alternative CD4 technologies for the enumeration of CD4 lymphocytes
Journal of Immunological Methods, 1994Enumeration of CD4+ T cells from persons infected with the human immunodeficiency virus (HIV) is important. Traditionally this measurement has been calculated by multiplying the percent of lymphocytes that are CD4+ T cells (from flow cytometry) and the number of lymphocytes per microliter of blood (from hematology measures).
J K, Nicholson +4 more
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CD4-dependent and CD4-independent HIV-2
AIDS, 2003HIV-2 is less pathogenic than HIV-1. In contrast to HIV-1, many isolates of HIV-2, including primary isolates, can infect cells independently of CD4.To compare the sensitivity of CD4-dependent and CD4-independent isolates of HIV-2 to antibody-mediated neutralization.The neutralization sensitivity of CD4-dependent and CD4-independent molecular clones of
Elaine R, Thomas +4 more
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Idiopathic CD4 lymphocytopenia
Current Opinion in Rheumatology, 2006A severe decrease of CD4 T cells predisposes humans to opportunistic infections. In adults, HIV is certainly the most common cause of CD4 lymphocytopenia, but other causes, such as infections, autoimmune diseases, immunosuppressive therapy, lymphoma and idiopathic forms need to be considered.
Walker, Ulrich A., Warnatz, Klaus
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Idiopathic CD4 lymphocytopenia
Allergy and Asthma Proceedings, 2016Idiopathic CD4 lymphocytopenia (ICL) is a rare disorder of unknown etiology. Diagnostic criteria include a persistent CD4 T-cell lymphopenia with no underlying primary or secondary immune deficiencies and a CD4 T-cell count of 300 cells/mL or 20% total lymphocyte on multiple occasions.To increase awareness of ICL and to provide a review of the clinical
Joel P, Brooks, Gisoo, Ghaffari
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Current Opinion in Immunology, 1991
The three-dimensional structure of the binding domain of the CD4 molecule has been determined and extensive mutational analyses of the respective binding sites on gp120 and CD4 have been completed. The consequences of gp120-CD4 binding with respect to secondary changes in the virion, or the cell, that may be required for infection or that may interfere
J S, McDougal +2 more
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The three-dimensional structure of the binding domain of the CD4 molecule has been determined and extensive mutational analyses of the respective binding sites on gp120 and CD4 have been completed. The consequences of gp120-CD4 binding with respect to secondary changes in the virion, or the cell, that may be required for infection or that may interfere
J S, McDougal +2 more
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CD4 and the Immunopathology of AIDS
American Journal of Respiratory Cell and Molecular Biology, 1989Since its original description as a lymphoycte differentiation antigen in 1980, much has been learned about the cell surface glycoprotein CD4. Initially identified on T lymphocytes with helper/inducer function, CD4 has a wider distribution and is present on some T lymphocytes with suppressor, cytotoxic, or macrophage-activating function.
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Cd4+ T cell apoptosis induced by anti-CD4 antibodies
Current Medical Science, 2000To explore the inhibitory effects of anti-CD4 human/murine chimeric antibodies on lymphocyte proliferation, CD4+ T cell apoptosis induced by anti-CD4 antibodies was examined. Annexin-V-FITC and PI double stain method was employed to qualitatively and quantitatively determined CD4+ T cell apoptosis induced by anti-CD4 antibodies. Our results showed that
Z, Zhang +4 more
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1996
The CD4 molecule plays an important role in the development of CD4+T lymphocytes and it also acts as a coreceptor to enhance responses mediated via the TCR. It is now established that CD4 functions both as an adhesion molecule favoring the T cell: APC interaction and as a signaling molecule.
K S, Ravichandran +2 more
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The CD4 molecule plays an important role in the development of CD4+T lymphocytes and it also acts as a coreceptor to enhance responses mediated via the TCR. It is now established that CD4 functions both as an adhesion molecule favoring the T cell: APC interaction and as a signaling molecule.
K S, Ravichandran +2 more
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Rheumatic Disease Clinics of North America, 1998
Animal models of human autoimmune disease suggest that it should be possible to reinduce self-tolerance in these conditions by the use of T-cell directed therapies, in particular with anti-CD4 monoclonal antibodies (CD4-mAb). Many studies have shown that CD4-mAb can prevent and in a treatment setting suppress activity of these disease models, including
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Animal models of human autoimmune disease suggest that it should be possible to reinduce self-tolerance in these conditions by the use of T-cell directed therapies, in particular with anti-CD4 monoclonal antibodies (CD4-mAb). Many studies have shown that CD4-mAb can prevent and in a treatment setting suppress activity of these disease models, including
openaire +2 more sources