Results 151 to 160 of about 575,439 (264)

HLA‐DR+ Schwann Cells Generate the Protumor Cancer‐Neuron‐Immune Niche in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
Hijacked and educated by HNSCC cells, HLA‐DR+ Schwann cells lost their normal neural‐related functions but acquired immunoregulatory phenotypes to promote CD4+ T cells transform into Tregs. HLA‐DR+ Schwann cells induced a macrophage subpopulation, Il1β.
Xiaoyan Meng, Zhonglong Liu, Shijian Zhang, Luoman Gan, Liren Cao, Jingjing Sun, Lingfang Zhang, Yue He   +7 more
wiley   +1 more source

A homozygous CTLA-4 variant causes CTLA-4 deficiency with severe immune dysregulation. [PDF]

J Hum Immun
Catak MC, Can S, Hubrack S, Bayram Catak F, Elmi A, Babayeva R, Amirov R, Yorgun Altunbas M, Bilgic Eltan S, Ertem D, Yilmaz B, Koc A, Erman B, Bozkurtlar E, Karakoc-Aydiner E, Ozen A, Lo B, Baris S.   +17 more
europepmc   +1 more source

Antigen Spreading via Localized Administration Enhances Adoptive TCR‐T Cell Therapy in Pancreatic Cancer

Advanced Science, EarlyView.
Cancer vaccines face limitations in pancreatic cancer due to insufficient tumor antigens. This ionic liquid ILvax via local tumor delivery triggers robust cDC1‐dependent systemic anti‐tumor immunity. It boosts endogenous CD8+ T cells and optimizes adoptive TCR‐T function, providing a promising synergistic therapeutic strategy.
Junming Huang, Qin Wang, Zhuo Yao, Qing Wang, Yongtao Ji, Minqi Yang, Meng Wang, Shiyi Shao, Xinyu Zhao, Fu Zhang, Tingbo Liang, Qida Hu   +11 more
wiley   +1 more source

Intestinal resident effector-memory CD4 T cells on the adaptive-innate spectrum comprise IL-18 reactivity and adaptive CMV specificity. [PDF]

Sci Adv
Kammann T, Voigt I, Wild N, Kokkinou E, Cai C, Sekine T, Nilsén V, Weigel W, Tibbitt C, Stamper C, Marchalot A, Bassett J, Kaushal J, Ferreira S, Mouchtaridi E, Raineri EJM, Müller TR, Ballesteros OR, Gao Y, Mily A, Adamo S, Constantz C, Rødahl I, Brownlie D, Michaelsson J, Mjösberg J, Birk M, Buggert M, Marquardt N, Jorns C, Sandberg JK.   +30 more
europepmc   +1 more source

SPADE: A Deep Learning Framework for Spatial Mapping and Quantitative Cell–Cell Interaction Inference

Advanced Science, EarlyView.
SPADE integrates spatial transcriptomics with single‐cell RNA sequencing by using cell–cell communications (CCC) as a guide for spatial mapping. It improves cell‐type localization, enhances sparse gene‐expression signals, and reveals CCC programs at single‐spot resolution.
Xinyi Li, Ning Zhang, Zijie Jin
wiley   +1 more source

Development of a Split Esterase for Protein–Protein Interaction-Dependent Small-Molecule Activation

ACS Central Science, 2019
Krysten A. Jones, Kaitlin Kentala, Michael W. Beck, Weiwei An, Alexander R. Lippert, Jared C. Lewis, Bryan C. Dickinson   +6 more
doaj   +1 more source

Lymphocyte CD4/CD8 ratio predicts early immune-related toxicity in lung cancer patients treated with immune checkpoint inhibitors: a single-center retrospective study. [PDF]

Front Med (Lausanne)
Jin W, Zhao Y, Lv Y, Yao Y, Su X.
europepmc   +1 more source

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

Advanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang   +10 more
wiley   +1 more source

CD4⁺ T Lymphocytes-From Their Multiple Immunological Roles to New Sensing Strategies Using Marine Magnetotactic Bacteria-A Systematic Review. [PDF]

Sensors (Basel)
Paul NL, Popa CO, Ionescu RE.
europepmc   +1 more source

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source