Results 211 to 220 of about 727,847 (314)

Structural Diversity of Monoclonal CD4 Antibodies and Their Capacity to Block the HIV GP120/CD4 Interaction [PDF]

, 1996
Rieber, Ernst P., Reiter, Christian, Federle, Christine, Chen, Ying-Hua, Weissenhorn, Winfried, Weiss, Elisabeth H., Riethmüller, Gert   +6 more
core   +1 more source

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

Advanced Science, EarlyView.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai, Keyu Wang, Jiali Fang, Shaorui Jia, Yansong Shi, Wanfeng Gao, Xinpeng Liu, Jiaqiang Li, Zenghui Cui, Yazhi Qian, Xiaosu Chen, Dan Ding, Xuetao Cao   +12 more
wiley   +1 more source

Circulating cell populations as response predictors and targets to improve immunotherapy in metastatic lung cancer. [PDF]

iScience
Figueiredo AB, Evangelista GFB, Ferreira SMI, Kuil LM, Barbeta G, Iohan LC, Faccio AT, Cardozo KHM, Carvalho VM, Cavalcanti CM, Balderas R, Lopes RP, Turner J, Souza-Silva TG, Silva JCS, Avila JP, Nakaya HTI, Galdino NAL, Lopes AD, Morais KLP, Santos IP, Freitas HC, Gross JL, Pinto CAL, Chojniak R, Dutra WO, Cordeiro-de-Lima VC, Gollob KJ.   +27 more
europepmc   +1 more source

Targeting Lactate‐Driven Stromal Autophagy via MCT1 Disrupts the Immunosuppressive Niche and Sensitizes Pancreatic Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
Tumor‐derived lactate activates PSCs through MCT1‐mediated Vps34 lactylation and autophagy. These activated PSCs secrete CXCL9/10, upregulating PD‐1 on CD8+ T cells via the CXCR3/STAT3 axis to foster immunosuppression. Disrupting this metabolic crosstalk by targeting MCT1 effectively sensitizes pancreatic cancer to PD‐1 blockade, presenting a promising
Wenfeng Zhuo, Rong Hu, Yuhang Hu, Ping Hu, Shengbo Han, Guozheng Lv, Zhu Zeng, Yong Zhao, Yang Li, Yan Huang, Yingsong Zhao, Hongda Wang, Guangyu Zhao, Eryang Zhao, Gang Zhao   +14 more
wiley   +1 more source

CD4⁺ T Lymphocytes-From Their Multiple Immunological Roles to New Sensing Strategies Using Marine Magnetotactic Bacteria-A Systematic Review. [PDF]

Sensors (Basel)
Paul NL, Popa CO, Ionescu RE.
europepmc   +1 more source

Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2‐Selective Small Molecule Inhibitor

Advanced Science, EarlyView.
The study characterizes C36, a highly selective EZH2/PRC2 inhibitor that acts via a novel allosteric mechanism. Unlike previous inhibitors, C36 inhibits EZH2/PRC2 by disrupting the allosteric communication between EZH2 and EED in a SAM‐noncompetitive manner.
Ting Cao, Dongdong Liu, Haishan Gao, Chenyang Qin, Wen Zhang, Ziyun Lu, Dongxia Tan, Yuxiu Qu, Yusong Liu, Zhiran Zou, Hongtao Yu, Wei Qi   +11 more
wiley   +1 more source

Differential expression of immune activation markers in T cells from patients with multiple myeloma. [PDF]

Front Oncol
Lin J, Zhang X, Zhao Y, Luo L, Yuan H, Zhong L.   +5 more
europepmc   +1 more source

Designer Dynamic DNA Nanoaggregate in Living Cell for Mitochondrial Energy Restriction

Advanced Science, EarlyView.
This study presents the Tech‐tetrahedron, a designer dynamic DNA nanoaggregate engineered for precise mitochondrial energy restriction. Its trinity‐functionalized design integrates navigable unit, telomerase‐activated latch, and self‐assembly module.
Ruijia Deng, Jing Sheng, Ben Niu, Wenjuan Fu, Yingjie Yang, Zuowei Xie, Shuang Xie, Yunxuan He, Meilin Gong, Jue Wang, Yan Pi, Ming Chen, Kai Chang   +12 more
wiley   +1 more source

Immune responses in aging adults. [PDF]

J Clin Invest
Weyand CM, Goronzy JJ.
europepmc   +1 more source