Results 251 to 260 of about 727,847 (314)

Stromal Regulation of Tumor Perineural Invasion: A Multicellular and Neuro‐Ecological Perspective

Advanced Science, EarlyView.
This review reframes perineural invasion (PNI) as a dynamic, multicellular process within the tumor–nerve–stromal ecosystem. The authors delineate how cancer‐associated fibroblasts, Schwann cells, and immune cells remodel the neural niche to facilitate tumor spread.
Xiaoyang Lin, Yingqiao Liu, Haitao Lin, Kang Feng, Xiqiang Liu   +4 more
wiley   +1 more source

Type-1 inflammatory imprinting and programmed responsiveness to CD40L enhance Siglec-1-dependent HIV-1 trans-infection by dendritic cells. [PDF]

Front Immunol
Bothwell EG, DePuyt AE, Zaccard CR, Anderko RR, Shoucair PEJ, Bilben HA, Garcia-Bates TM, Gerberick AD, Watkins SC, Sluis-Cremer N, Rinaldo CR, Mailliard RB.   +11 more
europepmc   +1 more source

An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

Advanced Science, EarlyView.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang, Congxue Hu, Hang Zhao, Xiao Peng, Yiming Yan, Jiasi Wang, Wenqi Jiang, Depeng Mu, Yan Cao, Xia Li, Yunpeng Zhang   +10 more
wiley   +1 more source

Machine learning risk stratification to identify people living with HIV at high risk of delayed ART and advanced immunosuppression: a precision public health approach. [PDF]

Front Public Health
Yin J, Li T, Jin J, Chen J, Ba H, Zhang Y, Li J, Liu H, Ma K.   +8 more
europepmc   +1 more source

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

Advanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan, Ruimin Chang, Meng Zhang, Qian Dong, Guanxiong Zhang, Xiang Chen, Mingliang Chen, Lixia Lu, Xiaowei Liang, Yeye Guo, Juan Su   +10 more
wiley   +1 more source

Long-acting IL-7 restores T-cell reconstitution in a humanized mouse model of lymphopenia. [PDF]

J Allergy Clin Immunol
Pérez-Díez A, Liu X, Bennett A, Barrios M, Anderson M, Wolfarth AA, Choi D, Lisco A, Sereti I.   +8 more
europepmc   +1 more source

Single-cell T-cell landscape in atherosclerosis: implications for targeted therapy and beyond. [PDF]

J Transl Med
Luo R, Liu S, Ouyang X, Zhou E, Jiang L.
europepmc   +1 more source

Transcriptional and functional profiling reveals unique activation of Adapter CAR T cells in acute myeloid leukemia. [PDF]

J Transl Med
Knelangen N, Bader U, Maniaki E, Engels B, Gattinoni L, Mittelstaet J.   +5 more
europepmc   +1 more source