Results 171 to 180 of about 780,218 (307)

CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization

Advanced Science, EarlyView.
In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin, Shicong Zheng, Pei Song, Jie Chang, Zewei Chen, Cang Li, Min Yu, Lude Wang, Shian Yu   +8 more
wiley   +1 more source

Time Series Transformer for long-term CD4 trajectory prediction in HIV patients: a novel deep learning approach. [PDF]

Front Cell Infect Microbiol
Lu Q, Li T, Chen J, Ba H, Zhang Y, Li J, Yin J, Ma K, Liu H, Jin J.   +9 more
europepmc   +1 more source

Oral Prebiotic Polysaccharide Hydrogels Sustaining Colon Antibody Release Alleviate Inflammatory Bowel Disease

Advanced Science, EarlyView.
An orally administered prebiotic polysaccharide hydrogel (predaGel) based on inulin and alginate‐dopamine is stable in the stomach, adheres to the intestine, and degrades slowly in the colon. It enables site‐specific delivery of anti‐TNF‐α and anti‐IL‐12/23 antibodies, scavenges reactive oxygen species, and remodels gut microbiota, offering effective ...
Xinyi Dong, Huan He, Li Cao, Fenghua Meng, Zhiyuan Zhong   +4 more
wiley   +1 more source

Single-cell mapping of thymus-dependent naïve t-cell regeneration reveals CD61-associated states after hematopoietic stem cell transplantation. [PDF]

Exp Hematol Oncol
Zhang F, Jiang X, Fan S, Wang B, Wu Z, Zhou J, Zhang Q, Zhang Z, Tang J, Xu ZL, Wang Y, Huang XJ, Guo H.   +12 more
europepmc   +1 more source

Artificial Host‐Guest Recognition Directs Glycometabolically Engineered Macrophages to Tumors

Advanced Science, EarlyView.
Glycoengineered supramolecular macrophages (GSAR‐M) are developed using glycometabolic labeling for bioorthogonal host‐guest tumor targeting. This engineering approach unexpectedly enhances macrophage migration, phagocytosis, and pseudopodia formation. Consequently, GSAR‐M demonstrate robust tumor‐targeting specificity, effectively arrest tumor growth,
Zhiqing Yang, Qian Cheng, Ziyi Wang, Jianwen Wei, Qun Guan, Huazhong Yu, Qingwen Zhang, Caixia Yin, Ruibing Wang   +8 more
wiley   +1 more source

Sjögren's disease patients with no hyposalivation and with short oral dryness complaints contain more T cells in salivary gland parenchyma. [PDF]

Rheumatology (Oxford)
Yang T, Liefers SC, van der Vegt B, van der Geest KSM, de Leeuw K, Bootsma H, Kroese FGM, Pringle S.   +7 more
europepmc   +1 more source

CD4 [PDF]

Science-Business eXchange, 2013
openaire   +1 more source

A Spatially Directed Microneedle Patch Enables Intratumoral Co‐Delivery of FOLFIRINOX, Surufatinib, and Anti‐PD‐1 for Chemo‐Immunotherapy of Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
A double‐layered shell‐core microneedle patch is developed to co‐deliver FOLFIRINOX, surufatinib, and anti‐PD‐1 for localized chemo‐immunotherapy of PDAC. This strategy achieves sustained tumor suppression, reduces metastasis, and reprograms the TME by enhancing CD8+ T‐cell infiltration and inhibiting Tregs and M2 macrophages infiltration, while ...
Tingting Kong, Ximo Xu, Xiao Zhang, Chuntao Wu, Zhengjun Qiu, Beiyuan Hu, Zihao Qi, Qiang Tian, Yuqin Yang, Hanguang Dong, Fei Wu, Tuo Jin, Yan Zheng, Jiang Long   +13 more
wiley   +1 more source

CD4 cell-monitored treatment interruption in patients with a CD4 cell count > 500 x 106 cells/l

, 2005
BACKGROUND: Little is known about CD4 cell count changes in patients with high CD4 cell counts who interrupt antiretroviral therapy, especially in those with a nadir of 250-350 x 10 cells/l.
A. d'Arminio Monforte, L. Sighinolfi, V. Borghi, International Study Group on CD4 monitored Treatment Interruptions, P. Ortolani, A. De Luca, A. Bedini, R. Enilia, A. Cozzi Lepri, R. Esposito, E. Barchi, A. Cossarizza, A. Antinori, S. Di Giambenedetto, A. N. Philips, C. Mussini, G. Guaraldi, G. Bratt, L. E. Eriksson   +18 more
core  

Digital twin technology for HIV patient virtual modeling: a novel approach to treatment optimization. [PDF]

Front Pharmacol
Zhang Y, Li T, Chen J, Ba H, Li J, Yin J, Ma K, Liu H, Jin J.   +8 more
europepmc   +1 more source