Results 71 to 80 of about 807,388 (265)

DC-SIGN increases the affinity of HIV-1 envelope glycoprotein interaction with CD4 [PDF]

, 2011
Mannose-binding C-type lectin receptors, expressed on Langerhans cells and subepithelial dendritic cells (DCs) of cervico-vaginal tissues, play an important role in HIV-1 capture and subsequent dissemination to lymph nodes. DC-SIGN has been implicated in
Wang, Yufei, Shattock, R., Longstaff, C., Ian M. Jones, Beth Haggarty, Longstaff, Colin, Charles G Kelly, James Hoxie, Robin Shattock, Schols, Dominique, Jones, I. M., Vanham, G., Scala Carlo, Hijazi, Karolin, Kelly, Charles G, Hoxie James, Kelly Charles G., Balzarini Jan, Shattock Robin, Ian M Jones, Vanham, Guido, Kelly, C. G., Carlo Scala, Schols Dominique, Colin Longstaff, Dominique Schols, Wang, Y., Hoxie, J., Balzarini, Jan, Jones, Ian, Yufei Wang, Stieh, Daniel, Hijazi, K., Scala, Carlo, Stieh, D., Charles G. Kelly, Jones Ian M., Jones, Ian M., Longstaff Colin, Scala, C., Schols, D., Haggarty, Beth, Balzarini, J., Daniel Stieh, Jeffs, Simon, Hijazi Karolin, Kelly, Charles G., Hoxie, James, Jones, Ian M, Jan Balzarini, Wang Yufei, Guido Vanham, Jeffs Simon, Vanham Guido, Haggarty, B., Haggarty Beth, Jeffs, S., Karolin Hijazi, Stieh Daniel, Simon Jeffs, Shattock, Robin, et al.   +61 more
core   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Correlations Between Anti-SARS-CoV-2 Titers, CD4+ T-Cell Counts, and COVID-19 Severity

Biology, Medicine & Natural Product Chemistry
Coronavirus disease 2019 (COVID-19) presents with diverse symptoms ranging from mild to severe. Patients with severe COVID-19 can show impaired humoral and cellular immunity and excessive pro-inflammatory cytokine production.
Edwin Hadinata, Eko Surachmanto, Paul N. Harijanto   +2 more
doaj   +1 more source

xilin93/Single-cell-analysis-of-GF-SI-CD4-cells: GFSICD4V1.0.0

, 2023
Full Changelog: https://github.com/xilin93/Single-cell-analysis-of-GF-SI-CD4-cells/commits/V1.0.
xilin93
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

The impact of chronic stress associated with active armed conflict in Ukraine on the state of immunity in patients with autoimmune thyroiditis

Mìžnarodnij Endokrinologìčnij Žurnal
Background. In the context of prolonged war-related stress in Ukraine, the prevalence of psychoemotional disorders has markedly increased, significantly influencing the course of autoimmune diseases.
Yu.I. Karachentsev, I.V. Gopkalova, V.N. Dubovik, O.A. Goncharova, E.M. Ashurov, L.V. Gerasimenko, V.А. Makedonska   +6 more
doaj   +1 more source

Rapid and long-term disappearance of CD4+ T lymphocyte responses specific for Anaplasma marginale major surface protein-2 (MSP2) in MSP2 vaccinates following challenge with live A. marginale [PDF]

, 2005
In humans and ruminants infected with Anaplasma, the major surface protein 2 (MSP2) is immunodominant. Numerous CD4(+) T cell epitopes in the hypervariable and conserved regions of MSP2 contribute to this immunodominance.
Abbott, Jeffrey R, Howard, Chris J, Palmer, Guy H, Kegerreis, Kimberly A, Brown, Wendy C, Hope, Jayne; id_orcid, Hope, Jayne C, Hetrick, Peter F   +7 more
core   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Understanding the slow depletion of memory CD4(+) T cells in HIV infection [PDF]

, 2007
Background The asymptomatic phase of HIV infection is characterised by a slow decline of peripheral blood CD4(+) T cells. Why this decline is slow is not understood.
Nigel Klein, Klein Nigel, Antia, Rustom, Yates, Andrew, Callard, Robin, Antia Rustom, Yates, A, Callard, R, Klein, Nigel, Jaroslav Stark, Stark, J, Andrew Yates, Stark Jaroslav, Rustom Antia, Callard Robin, Stark, Jaroslav, Yates Andrew, Robin Callard, Klein, N, Antia, R   +19 more
core   +2 more sources

Balance of CD4⁺IFNγ+ and CD4⁺CD25^hiT cells as early predictor of a 3-month outcome in ischemic stroke patients

Медицинская иммунология, 2020
Early prediction for ischemic stroke (IS) outcome is a major challenge since it may help to optimize treatment program and  to make  it more  personalized. Since  T cells with  regulatory activity  are involved  in different  pathophysiological processes 
S. A. Morozov, M. A. Tikhonova, N. V. Pronkina, A. A. Shtobbe, O. Yu. Leplina, E. Ya. Shevela, A. A. Ostanin, E. R. Chernykh   +7 more
doaj   +1 more source