Results 71 to 80 of about 276,570 (260)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

THE IMMUNOSTIMULAN POTENTIAL OF TENGGULUN (PROTIUM JAVANICUM) LEAVES TOWARDS T CELL CD4+ AND IFNγ SECRETION ON PBMC CHICKEN

Indonesian Journal of Tropical and Infectious Disease, 2017
One of the plants with immunostimulant activity is Tenggulun leaves which contain of flavonoid, like terpenoid. The aim of this research is to find the potential of Tenggulun’s leaves extract to have the immunostimulant activities.
Andi Jayawardhana, Heni Puspitasari, Dewa Ketut Meles, Setiawan Koesdarto   +3 more
doaj   +1 more source

CD4 Phosphorylation Partially Reverses Nef Down-Regulation of CD4 [PDF]

The Journal of Immunology, 2004
Abstract HIV Nef down-regulates CD4 from the cell surface in the absence of CD4 phosphorylation, whereas PMA down-regulates CD4 through a phosphorylation-dependent pathway. In this study we show that the down-regulation of CD4 in human Jurkat T cells expressing Nef was nearly complete (∼95%), whereas that induced by PMA was partial (∼40%)
Yong-Jiu, Jin, Xiaoping, Zhang, J Gildade, Boursiquot, Steven J, Burakoff   +3 more
openaire   +2 more sources

Normal Range of CD4 Cell Counts and Temporal Changes in Two HIVNegative Malawian Populations. [PDF]

, 2011
Longitudinal studies were carried out to determine trends in CD4 cell counts over a four year period in healthy HIV-negative adults in a rural (134 individuals) and an urban (80 individuals) site in Malawi, using TruCountTM and FACScountTM platforms.
Longwe, H, Crampin, A.C., Longwe, H., Crampin, AC, Mwaungulu, FD, French, N, Mwaungulu, F.D., Ambrose, L.R., Ambrose, LR, French, N., Crampin A.C.   +10 more
core   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

DC-SIGN increases the affinity of HIV-1 envelope glycoprotein interaction with CD4 [PDF]

, 2011
Mannose-binding C-type lectin receptors, expressed on Langerhans cells and subepithelial dendritic cells (DCs) of cervico-vaginal tissues, play an important role in HIV-1 capture and subsequent dissemination to lymph nodes. DC-SIGN has been implicated in
Wang, Yufei, Shattock, R., Longstaff, C., Ian M. Jones, Beth Haggarty, Longstaff, Colin, Charles G Kelly, James Hoxie, Robin Shattock, Schols, Dominique, Jones, I. M., Vanham, G., Scala Carlo, Hijazi, Karolin, Kelly, Charles G, Hoxie James, Kelly Charles G., Balzarini Jan, Shattock Robin, Ian M Jones, Vanham, Guido, Kelly, C. G., Carlo Scala, Schols Dominique, Colin Longstaff, Dominique Schols, Wang, Y., Hoxie, J., Balzarini, Jan, Jones, Ian, Yufei Wang, Stieh, Daniel, Hijazi, K., Scala, Carlo, Stieh, D., Charles G. Kelly, Jones Ian M., Jones, Ian M., Longstaff Colin, Scala, C., Schols, D., Haggarty, Beth, Balzarini, J., Daniel Stieh, Jeffs, Simon, Hijazi Karolin, Kelly, Charles G., Hoxie, James, Jones, Ian M, Jan Balzarini, Wang Yufei, Guido Vanham, Jeffs Simon, Vanham Guido, Haggarty, B., Haggarty Beth, Jeffs, S., Karolin Hijazi, Stieh Daniel, Simon Jeffs, Shattock, Robin, et al.   +61 more
core   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Correlations Between Anti-SARS-CoV-2 Titers, CD4+ T-Cell Counts, and COVID-19 Severity

Biology, Medicine & Natural Product Chemistry
Coronavirus disease 2019 (COVID-19) presents with diverse symptoms ranging from mild to severe. Patients with severe COVID-19 can show impaired humoral and cellular immunity and excessive pro-inflammatory cytokine production.
Edwin Hadinata, Eko Surachmanto, Paul N. Harijanto   +2 more
doaj   +1 more source

Understanding the slow depletion of memory CD4(+) T cells in HIV infection [PDF]

, 2007
Background The asymptomatic phase of HIV infection is characterised by a slow decline of peripheral blood CD4(+) T cells. Why this decline is slow is not understood.
Nigel Klein, Klein Nigel, Antia, Rustom, Yates, Andrew, Callard, Robin, Antia Rustom, Yates, A, Callard, R, Klein, Nigel, Jaroslav Stark, Stark, J, Andrew Yates, Stark Jaroslav, Rustom Antia, Callard Robin, Stark, Jaroslav, Yates Andrew, Robin Callard, Klein, N, Antia, R   +19 more
core   +2 more sources

xilin93/Single-cell-analysis-of-GF-SI-CD4-cells: GFSICD4V1.0.0

, 2023
Full Changelog: https://github.com/xilin93/Single-cell-analysis-of-GF-SI-CD4-cells/commits/V1.0.
xilin93
core   +1 more source