Results 31 to 40 of about 780,218 (307)

Effects of Soluble CD4 on Simian Immunodeficiency Virus Infection of CD4-Positive and CD4-Negative Cells [PDF]

Journal of Virology, 1999
ABSTRACT A soluble form of the CD4 receptor (sCD4) can either enhance or inhibit the infection of cells by simian immunodeficiency virus (SIV) and human immunodeficiency virus. We investigated the basis for these varying effects by studying the entry of three SIV isolates into CD4-positive and CD4-negative cells expressing different chemokine
SCHENTEN D., MARCON, LUISA, KARLSSON G., PAROLIN, MARIA CRISTINA, KODAMA T., GERARD N., SODROSKI J.   +6 more
openaire   +3 more sources

Effect of pembrolizumab on CD4+CD25+, CD4+LAP+ and CD4+TIM-3+ T cell subsets [PDF]

Clinical and Experimental Immunology, 2019
Summary Tumor immune evasion involves the expansion of avidly proliferating immunosuppressive cells and inhibition of effector T cell proliferation. Immune checkpoints (IC) block the activation pathways of tumor-reactive T cells. IC pathways are often exploited by tumor cells to evade immune destruction, and blocking these pathways ...
S M Toor, V Sasidharan Nair, G Pfister, E Elkord   +3 more
openaire   +2 more sources

HLA‐Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapy [PDF]

, 2008
We assessed the influence of human leukocyte antigen (HLA) alleles HLA-Bw4 and HLA-Bw6 on CD4 T cell recovery after starting successful combination antiretroviral therapy in 265 individuals. The median gains in the CD4 T cell count after 4 years were 258
Battegay, Manuel, Günthard, Huldrych F, Gaudieri, S., Swiss, HIV Cohort Study, John, Mina, Nolan, David, James, Ian, Furrer, H, Schmid, P, Battegay, M., McKinnon, E, Rauch, A., Swiss HIV Cohort Study, ., McKinnon, E., Telenti, A, Günthard, Huldrych F., Schmid, Patrick, Rauch, A, John, M., James, I, Furrer, Hansjakob, Hirschel, Bernard, Telenti, Amalio, Schmid, P., Furrer, H., Rauch, Andri, John, M, Günthard, H.F., Mallal, Simon, Telenti, A., McKinnon, Elizabeth, Nolan, D., Günthard, H F, Hirschel, B, Günthard, H. F., Battegay, M, Hirschel, B., Nolan, D, Mallal, S, James, I., Gaudieri, Silvana, Mallal, S., Gaudieri, S   +42 more
core   +2 more sources

Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue [PDF]

, 2011
The upper respiratory tract mucosa is the location for commensal Streptococcus (S.) pneumoniae colonization and therefore represents a major site of contact between host and bacteria.
Mitchell, T.J., Pido-Lopez Jeffrey, Pido-Lopez, J., Mitchell, TJ, Williams Neil A., Kwok, William W, Robert S. Heyderman, Neil A. Williams, Mitchell, Timothy J, Heyderman Robert S., Robert S Heyderman, Williams, NA, Pido, J, Neil A Williams, Mitchell Timothy J., Timothy J. Mitchell, Timothy J Mitchell, Heyderman, R.S., Pido-Lopez, Jeffrey, Kwok, W, Kwok William W., Williams, N.A., Heyderman, RS, William W Kwok, Jeffrey Pido-Lopez, Williams, Neil A, Kwok, W.W., William W. Kwok, Heyderman, Robert S   +28 more
core   +1 more source

Comparative Analysis of Conformational Dynamics and Systematic Characterization of Cryptic Pockets in the SARS-CoV-2 Omicron BA.2, BA.2.75 and XBB.1 Spike Complexes with the ACE2 Host Receptor: Confluence of Binding and Structural Plasticity in Mediating Networks of Conserved Allosteric Sites

Viruses, 2023
In the current study, we explore coarse-grained simulations and atomistic molecular dynamics together with binding energetics scanning and cryptic pocket detection in a comparative examination of conformational landscapes and systematic characterization ...
Mohammed Alshahrani, Grace Gupta, Sian Xiao, Peng Tao, Gennady Verkhivker   +4 more
doaj   +1 more source

Effects of fermented Crescentia cujete L. on the profile of haematology, clinical chemistry and circulatory CD4+/CD8+ in Sprague Dawley rats

Open Veterinary Journal
Background: The calabash (Crescentia cujete L.) is a tropical fruit that offers numerous health benefits. Its fermented form (FC) has been found to affect the neurological system positively.
Agustina Dwi Wijayanti, Yos Adi Prakoso, Krestel Joy Viernes Isla   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Analysis Activity of Elephantopus scaber Leaves Extract Against Quantitative Changes of Lymphocytes Cells in BALB/c Mice After Induction of DMBA and Estrogen

Journal of Experimental Life Science, 2019
The carcinogenic compounds such as DMBA known for having the ability to promote the DNA damage that affects the growth regulator genes. Therefore, uncontrolled cell growth will occur and change the immune system. Elephantopus scaber extract is considered
Lailiyavina Rochmatika, Sri Widyarti, Muhammad Sasmito Djati   +2 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Combinatorial functions of two chimeric antibodies directed to human CD4 and one directed to the a-chain of the human interleukin-2 receptor [PDF]

, 1992
The general feasibility of chimerization of monoclonal antibodies (mAbs) has already been shown for a large number of them. In order to evaluate in vitro parameters relevant to immunosuppressive therapy, we have chimerized and synthesized two anti-CD4 ...
Schwirzke, Marina, Kaluzab, Brigitte, Reiter, Christian, Rieber, Ernst Peter, Scheuer, Werner, Flieger, Dimitri, Lenz, Helmut, Weissenhorn, Winfried, Weiss, Elisabeth H., Weidle, Ulrich H., Riethmüller, Gert   +10 more
core   +1 more source