Results 71 to 80 of about 780,218 (307)

Rapid turnover of effector-memory CD4(+) T cells in healthy humans [PDF]

, 2004
Memory T cells can be divided into central-memory (T(CM)) and effector-memory (T(EM)) cells, which differ in their functional properties. Although both subpopulations can persist long term, it is not known whether they are maintained by similar ...
Peter C.L. Beverley, Macallan, DC, Griffin, GE, George E. Griffin, Andrew T. Worth, Derek C. Macallan, Wallace, Diana, Diana Wallace, Ghattas, Hala, Zhang, Yan, Griffin, George E, Macallan, Derek C, Beverley, Peter, Zhang, Y, Ghattas, H, Beverley, Peter CL, Tough, David F, Hala Ghattas, Tough, DF, David F. Tough, De Lara, C, De Lara, Catherine, Beverley, PC, Yan Zhang, Catherine de Lara, Wallace, D, Worth, Andrew T, Worth, AT   +27 more
core   +1 more source

Hallazgos tomográficos pulmonares y su asociación con niveles de linfocitos T CD4+ en pacientes portadores del virus de inmunodeficiencia humana

Revista Chilena de Radiología
Las enfermedades respiratorias constituyen complicaciones frecuentes en la infección por VIH. La Tomografía Axial Computarizada de Alta Resolución (TACAR) ha demostrado ser superior a las técnicas de imagen convencionales para establecer diagnóstico de ...
Maryalejandra Mendoza de S, Joanna Santeliz C, Fanny Ochoa O, Ivy Contreras V, Fabiola Torres S, Mario Pérez M, Cleizer Altamiranda V   +6 more
doaj   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

IFN-γ-producing CD4+ T cells promote experimental cerebral malaria by modulating CD8+ T cell accumulation within the brain.

, 2012
It is well established that IFN-γ is required for the development of experimental cerebral malaria (ECM) during Plasmodium berghei ANKA infection of C57BL/6 mice. However, the temporal and tissue-specific cellular sources of IFN-γ during P.
Hunter, Christopher A, Couper, Kevin N, Riley, Eleanor M, Greig, Rachel, Blount, Daniel G, Blount, Daniel G., Stumhofer, Jason S, Hafalla, Julius CR, De Souza, J. Brian, Findlay, Emily Gwyer, Shaw, Tovah N, de Souza, J Brian, Riley, Eleanor M., Shaw, Tovah N., Stumhofer, Jason S., Hunter, Christopher A., Hafalla, Julius C R, Couper, Kevin N., Gwyer Findlay, Emily, Villegas-Mendez, Ana, de, Souza JB, Hunter, CA, Greig, R, Gwyer, Findlay E, Stumhofer, JS, Couper, KN, Blount, DG, Villegas-Mendez, A, Shaw, TN, Hafalla, JC, Riley, EM   +30 more
core   +1 more source

Mortality and its predictors among antiretroviral therapy naïve HIV-infected individuals with CD4 cell count ≥350 cells/mm(3) compared to the general population: data from a population-based prospective HIV cohort in Uganda. [PDF]

, 2014
BACKGROUND: Evidence exists that even at high CD4 counts, mortality among HIV-infected antiretroviral therapy (ART) naïve individuals is higher than that in the general population.
Masiira, Ben, Kaleebu, Pontiano, Kathy Baisley, Ben Masiira, Pontiano Kaleebu, Baisley, Kathy, Kazooba, Patrick, Billy N. Mayanja, Maher, Dermot, Patrick Kazooba, Mayanja, Billy N, Dermot Maher   +11 more
core   +1 more source

THE IMMUNOSTIMULAN POTENTIAL OF TENGGULUN (PROTIUM JAVANICUM) LEAVES TOWARDS T CELL CD4+ AND IFNγ SECRETION ON PBMC CHICKEN

Indonesian Journal of Tropical and Infectious Disease, 2017
One of the plants with immunostimulant activity is Tenggulun leaves which contain of flavonoid, like terpenoid. The aim of this research is to find the potential of Tenggulun’s leaves extract to have the immunostimulant activities.
Andi Jayawardhana, Heni Puspitasari, Dewa Ketut Meles, Setiawan Koesdarto   +3 more
doaj   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

CD4 and the immunoglobulin superfamily

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1993
Abstract The CD4 membrane glycoprotein was one of the first cell surface antigens to be identified using monoclonal antibodies. It was shown to have a central role in the control of the recognition of foreign proteins by T lymphocytes and later as a receptor for the human immunodeficiency virus (HIV).
Barclay, A. N., Brady, R. L., Davis, S. J., Lange, G.   +3 more
openaire   +4 more sources

CD4 Phosphorylation Partially Reverses Nef Down-Regulation of CD4 [PDF]

The Journal of Immunology, 2004
Abstract HIV Nef down-regulates CD4 from the cell surface in the absence of CD4 phosphorylation, whereas PMA down-regulates CD4 through a phosphorylation-dependent pathway. In this study we show that the down-regulation of CD4 in human Jurkat T cells expressing Nef was nearly complete (∼95%), whereas that induced by PMA was partial (∼40%)
Yong-Jiu, Jin, Xiaoping, Zhang, J Gildade, Boursiquot, Steven J, Burakoff   +3 more
openaire   +2 more sources

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source