Results 201 to 210 of about 576,584 (261)

A Programmable Calcification Nanoplatform for Loco‐Regional Calcification‐Immune Hepatocellular Carcinoma Therapy

Advanced Science, EarlyView.
An in situ‐grown BP‐CaO2 nanoplatform supplies coordinated Ca2+, endogenous phosphate, and oxidative stress to convert tumor calcification from a passive endpoint into an active immune‐remodeling process. Widespread hydroxyapatite deposition is visualized by CT, while multi‐omics reveals MCOLN2 as a calcium‐responsive mediator linking biomineralization
Long Liu, Peng Li, Zhixiang Lu, Shuqin Xu, Juanjuan Wang, Kai Ma, Haodong Yu, Can Zhou, Hu Chen, Gang Liu, Yi Lyu, Shuang Bai   +11 more
wiley   +1 more source

Long-acting IL-7 restores T-cell reconstitution in a humanized mouse model of lymphopenia. [PDF]

J Allergy Clin Immunol
Pérez-Díez A, Liu X, Bennett A, Barrios M, Anderson M, Wolfarth AA, Choi D, Lisco A, Sereti I.   +8 more
europepmc   +1 more source

A Glucose Metabolism‐Modulatory Nanobiohybrid Vaccine Platform Promotes Anti‐Tumor Immunity by Orchestrating Autophagy‐Dependent Cross‐Presentation and H2S‐Enhanced NLRP3 Inflammasome Signaling

Advanced Science, EarlyView.
A nanobiohybrid vaccine was designed by constructing a hydrogen‐bonded organic framework coencapsulated with glucose oxidase (GOx) and tumor antigens. This nanobiohybrid vaccine executed a GOx‐catalyzed enzyme reaction that disrupted glucose metabolism and induced redox imbalance in dendritic cells, leading to autophagy‐dependent antigen cross ...
Weidong Wang, Yimin Gong, Jianing Li, Tianze Wu, Mingli Deng, Yannan Yang   +5 more
wiley   +1 more source

CD73 activity controls cytotoxic CD4 T-cell response driving myocardial pathology in chronic Chagas disease. [PDF]

Front Immunol
Bergero G, Mazzocco YL, Cejas Gallardo ZM, Rivarola W, Del Rosso S, Aoki MP.   +5 more
europepmc   +1 more source

Rewiring Pyroptosis to Potentiate Cancer Immunotherapy via a Gasdermin D Agonist Bypassing Caspase‐3

Advanced Science, EarlyView.
This work introduces a small‐molecule agonist, DIBDO, that bypasses Casp‐3 to directly trigger GSDMD‐mediated pyroptosis in tumors. Activated by glutathione, DIBDO generates singlet oxygen and molecular iodine, blocking Casp‐3 pathways and inducing immunogenic cell death.
Dan Zhao, Lingling Zhang, Yue Wen, Lianghui Cheng, Sidan Tian, Fanling Meng, Liang Luo   +6 more
wiley   +1 more source

CCL5 hiCD4+ T Cells Regulate Macrophage Polarization and Promote Immunotherapy Response in Bladder Cancer. [PDF]

Cancer Res
Luo W, Wang Y, Wang H, Ji YA, Zhang J, Ran Q, Ao Y, Xu J, Zhang J, Cheng X, Wang L, Zhang Y, Zhang J, Ai C, Qin J, Jiang J, Lan W, Liu Q.   +17 more
europepmc   +1 more source

Profound immune suppression and exhaustion characterize refractory mycoplasma pneumoniae pneumonia in children. [PDF]

Front Immunol
Ma X, Wu Y, He F, Yao H, Cao L, Zhu C.
europepmc   +1 more source

Transcriptional and functional profiling reveals unique activation of Adapter CAR T cells in acute myeloid leukemia. [PDF]

J Transl Med
Knelangen N, Bader U, Maniaki E, Engels B, Gattinoni L, Mittelstaet J.   +5 more
europepmc   +1 more source

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The Structure of CD4

1996
The CD4 antigen was first identified by the W3/25 monoclonal antibody (mAb) in the rat and indeed was one of the first lymphocyte cell surface antigens to be defined by monoclonal antibodies in any species (Williams et al. 1977). The W3/25 mAb was of particular interest as it was the first marker for the sub-population of T lymphocytes with “helper ...
R L, Brady, A N, Barclay
openaire   +2 more sources