Results 101 to 110 of about 782,392 (306)

Comprehensive In Vitro Profiling Demonstrates Successful Immune Evasion of Bioengineered Immune‐Shielded Heart Valves

Advanced Healthcare Materials, EarlyView.
Living donor heart valves offer superior durability for pediatric patients but trigger immune rejection. Lentiviral delivery of viral immune‐evasion genes US2 and Serpin b9 into donor valve cells and valve tissue suppresses HLA expression, reduces PBMC clustering and cytotoxic killing, and induces transcriptional immune‐tolerance programs, paving the ...
Abraham van Wijk, Leanne Van den Berg, Isa B. M. Velraeds, Valentina Osorio Zuluaga, Emma T. M. Peereboom, Martijn J. W. E. Rabelink, Arnaud Zaldumbide, Rob C. Hoeben, Marie‐Jose T. H. Goumans, Eric Spierings, Carlijn V. C. Bouten, Marijn C. Peters   +11 more
wiley   +1 more source

The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells [PDF]

, 2007
We have addressed the role of the inducible costimulator (ICOS) in the development of T cell help for B cells and in the generation, survival and reactivation of memory CD4 T cells and B cells.
MacDonald, Andrew, Mahajan, Simmi, Fillatreau, Simon, Cervera, Ana, MacDonald, Andrew; id_orcid, Smith, Andrew, Gray, David, Ana Cervera, Perona-Wright, Georgia, Macleod, Megan, Andrew Smith, Stephen Meek, Megan MacLeod, Andrew MacDonald, Meek, Stephen, Simmi Mahajan, David Gray, Georgia Perona‐Wright, Simon Fillatreau   +18 more
core   +1 more source

Near‐Infrared Light‐Activated Polydopamine Nanoparticles Conjugated With Transferrin Peptides for Enhanced Brain Accumulation

Advanced Healthcare Materials, EarlyView.
This study demonstrates that Tf‐PDA NPs combine a receptor‐mediated targeting with mild photothermal activation to enhance nanoparticle accumulation in the brain. NIR‐activated Tf‐PDA NPs increase BBB permeability to NPs in vitro and in vivo without inducing cytotoxicity or adverse immune responses.
Rafaela Ferrão, Susana Simões, Paulo Rodrigues‐Santos, Vitor Francisco, Akhilesh Rai, Lino Ferreira   +5 more
wiley   +1 more source

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source

Prevalence and Predictors of CD4+ T-Lymphocytopenia Among HIV-Negative Tuberculosis Patients in Uganda

Research and Reports in Tropical Medicine, 2020
Joseph Baruch Baluku,1– 3 Joseph Musaazi,4 Rose Mulwana,1 Araali Robert Mugabo,1 Felix Bongomin,5 Winceslaus Katagira3 1Mulago National Referral Hospital, Pulmonology Division, Kampala, Uganda; 2Mildmay Uganda, Kampala, Uganda; 3Makerere University
Baluku JB, Musaazi J, Mulwana R, Mugabo AR, Bongomin F, Katagira W   +5 more
doaj  

Reference Intervals for Absolute and Percentage CD4+ T Lymphocytes among an Apparently Healthy Population in Addis Ababa, Ethiopia

International Journal of General Medicine, 2022
Dinkenesh Chalchisa,1,2 Yohannes Belay,1 Endalkachew Befekadu,3 Melkitu Kassaw,4 Letebrhan G/Egzeabher,5 Gebremedhin Gebremicael,1 Boki Lengiso,1 Dawit Chala,1 Zewdineh Sahlemariam,6 Estifanos Kebede,6 Ebba Abate,4 Aster Tsegaye2 1National HIV Reference ...
Chalchisa D, Belay Y, Befekadu E, Kassaw M, G/Egzeabher L, Gebremicael G, Lengiso B, Chala D, Sahlemariam Z, Kebede E, Abate E, Tsegaye A   +11 more
doaj  

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Regression of canine oral papillomas is associated with infiltration of CD4+ and CD8+ lymphocytes [PDF]

, 2001
Canine oral papillomavirus (COPV) infection is used in vaccine development against mucosal papillomaviruses. The predictable, spontaneous regression of the papillomas makes this an attractive system for analysis of cellular immunity.
Nicholls, Philip K., Parry, N.R., Gough, Gerald W., Anderson, Davina M., Gough, G.W., Stanley, M.A., Parry, Nigel R., Stanley, Margaret A., Nicholls, P.K., Moore, Peter F., Moore, Richard A., Moore, R.A., Anderson, D.M., Moore, P.F.   +13 more
core   +1 more source

The role of CD4+T cells in host protective responses against cutaneous Leishmaniasis using genome-wide transcriptomics. [PDF]

, 2013
Includes abstract.Includes bibliographical references.Leishmania major is a protozoan parasite and infection in the human host causes severe cutaneous Leishmaniasis.
Smith, Liezel C
core   +1 more source

Relationships between 2H4 (CD45RA) and UCHL1 (CD45RO) expression by normal blood CD4+CD8−, CD4−CD8+, CD4−CD8dim+, CD3+ CD4−CD8− and CD3−CD4−CD8− lymphocytes

Clinical and Experimental Immunology, 1990
SUMMARYWe characterized and established relationships between the expression of membrane 2H4 (CD45R A) and UCHL1 (CD45RO) by enriched lymphocyte fractions prepared by selective immunomagnetic depletion of monoclonal antibody-defined populations. Cell fractions analysed in this study could be divided into two broad groups according to the presence (CD.3+
S J, Richards, R A, Jones, B E, Roberts, D, Patel, C S, Scott   +4 more
openaire   +3 more sources