Results 61 to 70 of about 782,392 (306)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Normal Range of CD4 Cell Counts and Temporal Changes in Two HIVNegative Malawian Populations. [PDF]

, 2011
Longitudinal studies were carried out to determine trends in CD4 cell counts over a four year period in healthy HIV-negative adults in a rural (134 individuals) and an urban (80 individuals) site in Malawi, using TruCountTM and FACScountTM platforms.
Longwe, H, Crampin, A.C., Longwe, H., Crampin, AC, Mwaungulu, FD, French, N, Mwaungulu, F.D., Ambrose, L.R., Ambrose, LR, French, N., Crampin A.C.   +10 more
core   +1 more source

Immunomodulator effect of Cnidoscolus aconitifolius leaves extract on CD4+ and CD8+ expression in Salmonella typhimurium-infected mice [PDF]

Pharmaciana
Typhoid fever is a common health problem in the community caused by Salmonella bacteria. The incidence rate of this infection will increase if a person’s immune system is weakened.
Sholihatil Hidayati, Dhina Ayu Susanti, Rian Anggia Destiawan, Ahdiah Imroatul Muflihah, Rizka Handayani, Wima Anggitasari   +5 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Safety and immunogenicity of H1/IC31®, an adjuvanted TB subunit vaccine, in HIV-infected adults with CD4+ lymphocyte counts greater than 350 cells/mm3: a phase II, multi-centre, double-blind, randomized, placebo-controlled trial. [PDF]

, 2014
BACKGROUND: Novel tuberculosis vaccines should be safe, immunogenic, and effective in various population groups, including HIV-infected individuals. In this phase II multi-centre, double-blind, placebo-controlled trial, the safety and immunogenicity of ...
Said, Khadija, Benjamin M Kagina, Willem A Hanekom, Nicole Lenz (671838), Hoff, Søren T., Fielding, Katherine L., Ingrid Kromann (370517), Khadija Said, Hannah Jeffery, Gardiner, Nicolene, Trevor Beattie (671836), Willem A. Hanekom (125097), Daubenberger, Claudia, Klaus Reither, Peter Andersen, Trevor Beattie, Fielding, Katherine L, Scriba, Thomas J, Hoff, Søren T, Søren T. Hoff (246744), Ingrid Kromann, Pohl, Christian, Klaus Reither (259897), Landay, Alan, Katsoulis, Lynn, Lynn Katsoulis, Scriba, Thomas J., Katherine L Fielding, Bang, Peter, Christian Pohl, Peter Bang (671842), Jeffery, Hannah, Peter Bang, Hannah Jeffery (671839), Nicolene Gardiner (671837), Elisabeth J. Hughes (671841), Claudia Daubenberger, Elirehema Mfinanga (476407), Elisabeth J Hughes, Søren T Hoff, Hughes, Elisabeth J., Gavin J. Churchyard (143332), Elirehema Mfinanga, Kagina, Benjamin M, Nicole Lenz, Benjamin M. Kagina (671840), Thomas J Scriba, Khadija Said (476408), Churchyard, Gavin J, Hanekom, Willem A., Mfinanga, Elirehema, Beattie, Trevor, Christian Pohl (476404), Kagina, Benjamin M., Andersen, Peter, Hanekom, Willem A, Reither, Klaus, Nicolene Gardiner, Thomas J. Scriba (76847), Claudia Daubenberger (212658), Lynn Katsoulis (671835), Kromann, Ingrid, Gavin J Churchyard, Hughes, Elisabeth J, Peter Andersen (88335), Churchyard, Gavin J., Lenz, Nicole, Katherine L. Fielding (143336)   +67 more
core   +1 more source

Absolute CD4+ T cell count overstate immune recovery assessed by CD4+/CD8+ ratio in HIV-infected patients on treatment. [PDF]

PLoS ONE, 2018
OBJECTIVES:To analyse the correlation and concordance between aCD4, CD4%, CD4/CD8, their intra-patient variability, and to compare the immune recovery (IR) rates based on the three parameters in HIV-infected patients after starting antiretroviral therapy.
Yusnelkis Milanés-Guisado, Alicia Gutiérrez-Valencia, María Trujillo-Rodríguez, Nuria Espinosa, Pompeyo Viciana, Luis Fernando López-Cortés   +5 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

The phenotype of the Cryptococcus-specific CD4+ memory T-cell response is associated with disease severity and outcome in HIV-associated cryptococcal meningitis. [PDF]

, 2013
BACKGROUND: Correlates of immune protection in patients with human immunodeficiency virus (HIV)-associated cryptococcal meningitis are poorly defined.
Levitz, SM, Stone, Hunter H, Casazza, Joseph P, Richard A. Koup, Meintjes, Graeme, Levitz, Stuart M, Joseph P. Casazza, Joseph N. Jarvis, Stephen D. Lawn, Stuart M. Levitz, Harrison, Thomas S, Koup, RA, Lawn, Stephen D, Harrison, TS, Thomas S. Harrison, Koup, Richard A, Lawn, SD, Graeme Meintjes, Hunter H. Stone, Meintjes, G, Stone, HH, Jarvis, Joseph N, Jarvis, JN, Casazza, JP   +23 more
core   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Role of Leptin and metabolism in survival of autoreactive CD4+ T cells [PDF]

, 2009
Recent evidence has shown that leptin, the adipose-tissue derived hormone, can influence T cell homeostasis and survival through the control of genes involved in these processes. Leptin deficient ob/ob mice and humans show reduced circulating number of T
Galgani, Mario
core   +1 more source