Results 201 to 210 of about 499,185 (263)

Brain-infiltrating CD4 T cells drive inflammatory microglia proliferation during cryptococcal meningitis in mice. [PDF]

Nat Commun
Hain S, Fu MS, Wigg L, George L, Lecky D, Whitehead AJ, Clipston E, Sato K, Ono M, Wuthrich M, Klein B, Kawakami K, Rayes J, Bending D, Drummond RA.   +14 more
europepmc   +1 more source

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

T_H1 effector CD4 T cells rely on IFN-γ production to induce alopecia areata. [PDF]

Sci Adv
Connell SJ, Crotts S, Reis R, Lensing MM, Kahl P, Henderson N, Ayush O, Zhu Z, Ortolan LS, Ko AC, Shriver EM, Carter KD, Harty JT, Goverman JM, Jabbari A.   +14 more
europepmc   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

Intestinal challenges shape the polarisation of protective dural memory CD4 T cells

Fleming A, Marco-Barros RD, Posner DA, Lee CY, Stewart A, Tuong ZK, Neish K, Peñalver A, Cabantous M, Richoz N, Portet A, Harcourt K, Gillman E, Ruano-Gallego D, Frankel G, Withers D, Clare S, Clatworthy MR.   +17 more
europepmc   +1 more source

ProS1-MerTK signaling in CD4 T cells: implications for TIL expansion and functionality. [PDF]

Oncoimmunology
Kurzay A, Fresnillo Saló S, Rahbech A, Seremet T, Oelvang Madsen C, Chamberlain CA, Bülow Jensen E, Thy Luu V, Met Ö, Met Ö, Peeters MJW, Straten PT.   +11 more
europepmc   +1 more source

Large neutral amino acid uptake and mTOR activation within CD4 T cells coordinate type 2 immunity and host resistance to <i>Trichuris muris</i>. [PDF]

Discov Immunol
Krauss MZ, Hayes KS, Hodge SH, Villegas-Mendez A, Hepworth MR, Sinclair LV, Couper KN, Grencis RK.   +7 more
europepmc   +1 more source

Inhibition of protein kinase R suppresses HIV replication and integration in CD4 T cells. [PDF]

J Virus Erad
Pyburn J, Zhao J, Wang L, Schank M, Hill AC, Banik P, Zhang Y, Wu XY, Lightner JW, Orfield HK, Leshaodo TO, El Gazzar M, Ning S, Moorman JP, Yao ZQ.   +14 more
europepmc   +1 more source