Results 211 to 220 of about 511,615 (263)

SSR4 sustains Tertiary Lymphoid Structures by Regulation Quality Control of N‐linked Glycosylation During B‐cell Differentiation Into Plasmacyte in Colorectal Cancer

Advanced Science, EarlyView.
SSR4, a TRAP component induced in B cells, governs BAFFR N‐glycosylation via DDOST to sustain NF‐κB signaling, B‐cell differentiation, and TLS maturation. Its loss impairs anti‐tumor immunity, while overexpression improves antibody glycosylation and ADCC, revealing a critical regulator for cancer immunotherapy.
Wei Zhao, Youcai Zhao, Haiyang Li, Bowen Yang, Siyan Lu, Xueting Fu, Caixia Zhang, Yirong Chen, Xiaofeng Bian, Xinghua Ma, Xiaobing Yang, Bin Wang, Yuan Fang, Lulu Yang, Yelin Zhao, Shuli Zhao   +15 more
wiley   +1 more source

Mendelian randomization study of the role of TD CD4+ T cells in the association between Streptococcus thermophilus and esophageal cancer. [PDF]

Medicine (Baltimore)
Zhang Y, Li Q.
europepmc   +1 more source

TCF1+CD4+ T cells and microglia co-orchestrate tertiary lymphoid structures to enhance prognosis and immunotherapy in non-small cell lung cancer with brain metastases. [PDF]

EBioMedicine
Yu Q, Liao R, Zheng H, Li L, Huang Y, Tao Y, Deng R, He H, Yu L, Lin J, Huang S, Zhang X, Xu Z, Yang Z, Peng Y.   +14 more
europepmc   +1 more source

Histone demethylase JMJD1A protects mice from enteric bacterial infection by upregulating CCL8 expression to recruit macrophages and CD4+ T cells. [PDF]

PLoS Pathog
Lin G, Yang L, Jiang S, Zhang Y, Luo P, Li W, Xu J, Xiong G, Yu C, Chen W.   +9 more
europepmc   +1 more source

Cytotoxic CD4⁺ T cells exhibit an immunosuppressive shift in checkpoint immunotherapy resistance in melanoma patients. [PDF]

Cancer Immunol Immunother
Bae HR, Son B, Hwang K, Kim S, Young HA, Kwon EY.   +5 more
europepmc   +1 more source

The Antisense Protein ASP of HIV-1 Enhances Viral Entry in CD4+ T Cells. [PDF]

Viruses
Houmey MA, Caico I, Rivault A, Espert L, Mesnard JM, Romerio F, Chazal N.   +6 more
europepmc   +1 more source

Human CD4 T cells are a functional target for lipid nanoparticle-based mRNA vaccines. [PDF]

mBio
Kim SC, Felgner J, Soto MS, Hitchcock L, Silzel EK, Beares H, Hwang MJ, Yates TB, Cheng S, Joloya EM, Sureshchandra S, Sorn AM, Wagoner ZW, Tifrea D, Kabeer M, Trask D, Othy S, Felgner P, Wagar LE.   +18 more
europepmc   +1 more source

Intestinal challenges shape the polarisation of protective dural memory CD4 T cells

Fleming A, Marco-Barros RD, Posner DA, Lee CY, Stewart A, Tuong ZK, Neish K, Peñalver A, Cabantous M, Richoz N, Portet A, Harcourt K, Gillman E, Ruano-Gallego D, Frankel G, Withers D, Clare S, Clatworthy MR.   +17 more
europepmc   +1 more source

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CD4+ T cell memory

Nature Immunology, 2023
Specialized subpopulations of CD4+ T cells survey major histocompatibility complex class II-peptide complexes to control phagosomal infections, help B cells, regulate tissue homeostasis and repair or perform immune regulation. Memory CD4+ T cells are positioned throughout the body and not only protect the tissues from reinfection and cancer, but also ...
Marco Künzli, David Masopust
openaire   +2 more sources