Results 201 to 210 of about 511,615 (263)

Tumor‐Infiltrating mregDCs Restrain Anti‐Tumor Immunity in Early Relapse HCC

Advanced Science, EarlyView.
Tumor‐infiltrating mregDCs are regulated by the TNFR2‐non‐canonical NF‐κB axis, which is mediated by TNF‐α secreted by CD161+CD8+ T cells. These mregDCs recruit CD161+CD8+ T cells via the CCL20‐CCR6 axis, forming a positive feedback loop that enhances immunosuppression, promotes early recurrence of HCC, and further confirms TNFR2 as a key therapeutic ...
Zefan Zhang, Lin Ding, Yu Zhong, Haokang Feng, Linglong Huang, Waidong Huang, Chunqing Wang, Arne Östman, Beili Wang, Jian Zhou, Jia Fan, Wei Guo, Liang Wu, Yunfan Sun   +13 more
wiley   +1 more source

CD4 T cells correlate with better prognosis in medulloblastoma. [PDF]

Front Oncol
Zhang J, Ren S, Li S, Wang Y, Wan L, Gao W, Sun H, Gong X, Li M, Sun Y, Sun L, Li Z, Wang T, Du S, Wu W.   +14 more
europepmc   +1 more source

Supramolecular Assembly of Stepped‐Persistent ROS Nanogenerator for Sustained Tumor Immunotherapy

Advanced Science, EarlyView.
ROS catalytic systems often fail to achieve both effective tumor elimination and persistent immune activation due to their monotonous ROS production profiles. A stepped‐persistent ROS nanogenerator was developed by supramolecularly assembling multiple ROS generation modules within a nanofiber structure to simultaneously extend ROS generation duration ...
Zhenqiang Wang, Ming Qin, Wenjing Lai, Shiwen Chen, Fengling Wang, Dandan Xie, Maohua Chen, Changpeng Hu, Kui Wang, Rong Zhang, Guobing Li   +10 more
wiley   +1 more source

HIV infection reprogrammes CD4+ T cells for quiescence and entry into proviral latency. [PDF]

Nat Microbiol
Plasek Hegde LM, Gunawardane LS, Niazi F, Mbonye U, Leskov K, Perez G, Dobrowolski C, Shukla M, Nutt WS, Karn J, Valadkhan S.   +10 more
europepmc   +1 more source

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

β-adrenergic signaling blockade attenuates metastasis through activation of cytotoxic CD4 T cells. [PDF]

Nat Commun
Fjæstad KY, Johansen AZ, Linder H, Baker KJ, Schattefor M, Czajkowski NK, Thorseth ML, Siersbæk M, Kurzay A, Perez-Penco M, Rahbech A, Saló SF, Engelholm LH, Svane IM, Andersen MH, Junker N, Grøntved L, Straten PT, Madsen DH.   +18 more
europepmc   +1 more source

Reprogramming the Immune Landscape of Inflammatory Breast Cancer

Advanced Science, EarlyView.
Inflammatory breast cancer is the most lethal subtype of breast cancer and is characterized by an immunosuppressive tumor microenvironment (TME) driven by a complex network of immune cells and inflammatory cytokines, contributing to its aggressiveness and treatment challenges. Immune checkpoint inhibitors, either alone or in combination, show potential
Verena Martinez‐Rodriguez, Suguru Ogata, Xiaoping Wang, Naoto T. Ueno   +3 more
wiley   +1 more source

Human CD4+ T cells recognize Mycobacterium tuberculosis-infected macrophages amid broader responses. [PDF]

J Exp Med
Stetsenko V, Gail DP, Reba SM, Suzart VG, Schauner R, Sandhu AK, Sette A, Haj Dezfulian M, Lindestam Arlehamn CS, Carpenter SM.   +9 more
europepmc   +1 more source

Senescent Cell Derived Artificial Vesicle‐Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross‐Presentation Efficacy

Advanced Science, EarlyView.
A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang, Yubo Lai, Jia Wang, Lingling Liu, Jieyuan An, Mi Qu, Yuan Liang, Bijun Tan, Guodong Yang, Xuekang Yang, Lijun Yuan   +10 more
wiley   +1 more source

Symptomatic SARS-CoV-2 breakthrough infections broaden the repertoire of Spike-reactive CD4 T cells. [PDF]

mBio
Johansson E, Lee Y, Fajardo-Rosas V, Abawi A, Logandha Ramamoorthy Premlal A, Frazier A, Greenbaum JA, Vijayanand P, da Silva Antunes R, Sette A.   +9 more
europepmc   +1 more source