Results 231 to 240 of about 511,615 (263)
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CD4+ T cell dysfunction in cancer

Journal of Experimental Medicine
While the importance of CD8+ T cells in successful cancer immunotherapy is well-established, CD4+ T cells are increasingly recognized as key mediators of effective anti-tumor immunity. However, the mechanisms underlying the functional impairment of CD4+ T cells in tumors are not as well characterized as in CD8+ T cells.
Hrishi Venkatesh, Lawrence Fong
openaire   +2 more sources

CD4+ T-cell subsets in autoimmunity

Current Opinion in Immunology, 1997
The discovery that functionally heterogeneous CD4+ T-cell subsets secrete different cytokines offers an explanation for the ability of certain T cells to mediate a predominant cell-mediated immune response versus a humoral response often accompanied by allergic manifestations. Th1 cells, important for cell-mediated immunity by their production of IL-2,
A, O'Garra, L, Steinman, K, Gijbels
openaire   +2 more sources

Heterogeneity of CD4+ and CD8+ T cells

Current Opinion in Immunology, 2003
There is extensive plasticity in the T-cell response to antigen. Helper CD4(+) T cells, cytotoxic CD8(+) T cells, the progression from naïve to effector and memory T cells, and differentiation into Th1, Tc1, Th2 and Tc2 subsets have long been recognized.
David L, Woodland, Richard W, Dutton
openaire   +2 more sources

Editing naive CD4+ T cells

Nature Methods, 2021
Andrea Olga Papadopoulos   +1 more
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