Results 241 to 250 of about 649,118 (297)

TSTScope Unifies Single‐Cell Multi‐Omics to Identify Functional T Cell States Predictive of Immunotherapy Response

Advanced Science, EarlyView.
TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...
Shiwei Cao, Jinyu Cheng, Feng‐ao Wang, Chenxin Yi, Jiajun Chen, Keyue Wang, Lulu Liu, Junwei Liu, Yixue Li   +8 more
wiley   +1 more source

CCR5Δ32 polymorphism is associated with increased central memory CD4+ T cells in virologically suppressed people living with HIV on antiretroviral therapy. [PDF]

Med Microbiol Immunol
Lopes-Araujo HF, Carvalho-Silva WHV, Andrade-Santos JL, Guedes MCS, Souto FO, De Alencar LCA, Brennand IBLPB, Monteiro TKO, Feliciano-Santos K, Chies JAB, Guimarães RL.   +10 more
europepmc   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Cytotoxic CD4⁺ T Cells in Visceral Leishmaniasis Patients. [PDF]

Parasite Immunol
Chauhan SB, Singh SS, Singh B, Kumar S, Tiwari R, Gautam V, Rivera F, Nylen S, Engwerda C, Sundar S, Kumar R.   +10 more
europepmc   +1 more source

PARP Inhibitors plus Anlotinib as Bridging Therapy for Armored CAR‐T Cells in Ovarian Cancer Enhances Infiltration and Antitumor Efficacy

Advanced Science, EarlyView.
This study shows that a PARP inhibitor combined with anlotinib, administered as bridging therapy, preconditions the tumor microenvironment to enhance the infiltration and antitumor activity of subsequently infused CAR‐T cells across preclinical ovarian cancer models, supporting bridging therapy as a promising strategy to address limited CAR‐T cell ...
Huayi Li, Minghua Xiang, Qiuyang Xu, Jiahao Liu, Xiaofei Jiao, Wei Mu, Xiaoying Lv, Kangjia Tao, Yu Xu, Dongchen Zhou, Wenjian Gong, Danmei Yan, Yixin Hu, Sen Xu, Bingbing Zhao, Jundong Li, Yongkang Gai, Guang Hu, Li Zhu, Qinglei Gao, Yong Fang   +20 more
wiley   +1 more source

Exacerbation of Dahl SS Hypertension and Renal Damage by NOX2 in CD4+ T Cells. [PDF]

Hypertension
Walton SD, Burns-Ray EC, Dasinger JH, Hasan S, Baldwin KE, Cherian-Shaw M, Abais-Battad JM, Mattson DL.   +7 more
europepmc   +1 more source

Pre-Human Immunodeficiency Virus (HIV) infection Th17 CD4+ T cells as predictors of early HIV disease progression. [PDF]

PLoS Pathog
Omole TE, Nguyen HM, Marcinow A, Jahan N, Severini G, Naicker N, Thomas K, Celum C, Mugo N, Mujugira A, Kublin J, Corey L, Sivro A, Lingappa J, Gray G, McKinnon LR.   +15 more
europepmc   +1 more source

Deficiency of microRNA-10a in CD4+ T cells protects against intestinal infection through mitochondrial oxidation-IL-22 pathway. [PDF]

J Immunol
Yang W, Yu T, Yao S, Cong Y.
europepmc   +1 more source

Single cell multiomic analysis of the impact of Delta-9-tetrahydrocannabinol on HIV infected CD4 T cells. [PDF]

J Cannabis Res
Ashokkumar M, Ge RY, Cooper-Volkheimer A, Margolis DM, Li Q, Jiang Y, Murdoch DM, Browne EP.   +7 more
europepmc   +1 more source

Generation of effector CD4⁺ T cells from human iPSC. [PDF]

Stem Cell Reports
Amirault J, Heinze D, Yang M, Kerr CM, Bawa PS, Polanco L, Sgambettera GM, Wang F, Belkina AC, Snyder-Cappione JE, Mostoslavsky G.   +10 more
europepmc   +1 more source