Results 71 to 80 of about 511,615 (263)
International Journal of COPD, 2019 Zhao-Ji Meng,* Jiang-Hua Wu,* Mei Zhou, Sheng-Wen Sun, Shuai-Ying Miao, Hong-Li Han, Long Chen, Xian-Zhi XiongDepartment of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology ...
Meng ZJ +7 more
doaj
Molecular Therapy: Methods & Clinical Development, 2020 Activation, infection, and eventual depletion of human immunodeficiency virus (HIV)-specific cluster of differentiation 4 (CD4) T cells are the crucial pathogenetic events in acquired immunodeficiency syndrome (AIDS). We developed a cell and gene therapy
Haishan Li +6 more
doaj +1 more source
Natural Biomaterials for Osteochondral Repair: From Source to Strategy
Advanced Healthcare Materials, EarlyView.Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu +5 more
wiley +1 more source
Advanced Materials, EarlyView.An injectable cold atmospheric plasma‐activated decellularized tumor extracellular matrix hydrogel is introduced as a post‐surgical immunoactivation platform. The engineered gel attracts residual tumor cells and induces immunogenic cell death, reshaping the tumor microenvironment and eliciting systemic antitumor immunity. In combination with checkpoint
Tianxu Fang +5 more
wiley +1 more source
The exhausted CD4+CXCR5+ T cells involve the pathogenesis of human tuberculosis disease
International Journal of Infectious Diseases, 2018 Objectives: CD4+CXCR5+ T cells have previously been established. However, their decreased frequency during tuberculosis (TB) disease is only partially understood.
Munyemana Jean Bosco +7 more
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Advanced Science, EarlyView.We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang +10 more
wiley +1 more source
CD4 T cell responses to flaviviruses
Journal of Clinical Virology, 2018 Flaviviruses pose an increasing threat to global health with their potential to cause severe disease in millions of people. Protective and long-lived immunity is closely linked to the generation of CD4 T cells, which provide B cell help and support high affinity neutralizing antibody responses.
Judith H. Aberle +2 more
openaire +3 more sources
Advanced Science, EarlyView.This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang +13 more
wiley +1 more source
Frontiers in Immunology, 2019 Idiopathic T-CD4 lymphocytopenia (ICL) is a rare and heterogeneous syndrome characterized by opportunistic infections due to reduced CD4 T-lymphocytes (<300 cells/μl or <20% T-cells) in the absence of HIV infection and other primary causes of ...
Rosa Anita Fernandes +27 more
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CD4+ T cells: The great escape
Nature Medicine, 2001 Mutation is one way in which RNA viruses evade the destructive actions of CD8+ cytotoxic lymphocytes. New research shows that they employ the same method to escape attack by CD4+ T cells. (pages 795–800)
Phillips, R, Harcourt, G, Price, D
openaire +2 more sources