Results 51 to 60 of about 672,678 (303)

In vitro induction of regulatory CD4+CD8α+ T cells by TGF-β, IL-7 and IFN-γ. [PDF]

PLoS ONE, 2013
In vitro CD4(+) T cell differentiation systems have made important contributions to understanding the mechanisms underlying the differentiation of naive CD4(+) T cells into effector cells with distinct biological functions.
Luc Van Kaer, Whitney A S Rabacal, Holly M Scott Algood, Vrajesh V Parekh, Danyvid Olivares-Villagómez   +4 more
doaj   +1 more source

CD4+ T cells in atherosclerosis

Biomedicine & Pharmacotherapy, 2003
Atherosclerosis is an inflammatory disease. T lymphocytes, occurring concomitantly with macrophages, are found in atherosclerotic lesions with substantial numbers in all stages. Most of the T cells in the lesions are CD4(+) T cells. The finding of activated T cells and macrophages in lesions and cloning of T cells specific for modified low-density ...
openaire   +2 more sources

CD4+CD25+ TR cells suppress innate immune pathology through cytokine-dependent mechanisms [PDF]

, 2003
Copyright @ 2003 The Rockefeller University PressCD4+CD25+ regulatory T (TR) cells can inhibit a variety of autoimmune and inflammatory diseases, but the precise mechanisms by which they suppress immune responses in vivo remain unresolved.
Fiona Powrie, Maloy, Kevin J., Gordon Dougan, Powrie, Fiona, Dougan, Gordon, Laurence Salaun, Cahill, R, Saunders, NJ, Saunders, Nigel J., Nigel J. Saunders, Salaun, L, Powrie, F, Rachel Cahill, Kevin J. Maloy, Salaun, Laurence, Maloy, KJ, Dougan, G, Cahill, Rachel   +17 more
core   +1 more source

CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection

Cell Reports, 2021
Summary: CD4 T cells are essential for immunity to tuberculosis because they produce cytokines, including interferon-γ. Whether CD4 T cells act as “helper” cells to promote optimal CD8 T cell responses during Mycobacterium tuberculosis is unknown.
Yu-Jung Lu, Palmira Barreira-Silva, Shayla Boyce, Jennifer Powers, Kelly Cavallo, Samuel M. Behar   +5 more
doaj   +1 more source

Correlation of memory T cell responses against TRAP with protection from clinical malaria, and CD4+ CD25high T cells with susceptibility in Kenyans [PDF]

, 2008
Background - Immunity to malaria develops naturally in endemic regions, but the protective immune mechanisms are poorly understood. Many vaccination strategies aim to induce T cells against diverse pre-erythrocytic antigens, but correlates of protection ...
Magdalena Plebanski, Stephen M. Todryk, Plebanski Magdalena, Hill, Adrian, Tabitha Mwangi, Kevin Marsh, Urban Britta, Flanagan Katie L., Mwangi Tabitha, Plebanski, Magdalena, Britta Urban, Todryk, Stephen, Hill Adrian V. S., Urban, Britta, Katie L Flanagan, Philip Bejon, Bejon, Philip, Marsh Kevin, Mwangi, Tabitha, Flanagan, Katie, Bejon Philip, Katie L. Flanagan, Adrian V S Hill, Todryk Stephen M., Adrian V. S. Hill, Stephen M Todryk, Marsh, Kevin   +26 more
core   +1 more source

Understanding the slow depletion of memory CD4(+) T cells in HIV infection [PDF]

, 2007
Background The asymptomatic phase of HIV infection is characterised by a slow decline of peripheral blood CD4(+) T cells. Why this decline is slow is not understood.
Nigel Klein, Klein Nigel, Antia, Rustom, Yates, Andrew, Callard, Robin, Antia Rustom, Yates, A, Callard, R, Klein, Nigel, Jaroslav Stark, Stark, J, Andrew Yates, Stark Jaroslav, Rustom Antia, Callard Robin, Stark, Jaroslav, Yates Andrew, Robin Callard, Klein, N, Antia, R   +19 more
core   +2 more sources

Higher proportions of circulating CXCR3+ CCR6− Tfh cells as a hallmark of impaired CD4+ T-cell recovery in HIV-1-infected immunological non-responders

mBio
Despite long-term suppressive antiretroviral therapy (ART), immune dysregulation due to impaired reconstitution of CD4+ T cells is a major hurdle for reducing morbidity and mortality in HIV-1-infected immunological non-responders (INRs, CD4+ T cells ≤350
Ruthu Nagaraju, Pruthvi S. Gowda, Durai M. Gunasekaran, Anita S. Desai, Udaykumar Ranga, Ramesh N. R. Masthi, Manjunatha M. Venkataswamy   +6 more
doaj   +1 more source

Determinants of immunodominance for CD4 T cells [PDF]

Current Opinion in Immunology, 2015
The term immunodominance was originally defined as a restricted T cell response to a short peptide sequence derived from a given protein. The question of what determines immunodominance has been a longstanding battle for the past two decades. Hundreds of papers have been written on different aspects of epitope selection during antigen processing ...
AeRyon, Kim, Scheherazade, Sadegh-Nasseri   +1 more
openaire   +2 more sources

IFN-γ-producing CD4+ T cells promote experimental cerebral malaria by modulating CD8+ T cell accumulation within the brain.

, 2012
It is well established that IFN-γ is required for the development of experimental cerebral malaria (ECM) during Plasmodium berghei ANKA infection of C57BL/6 mice. However, the temporal and tissue-specific cellular sources of IFN-γ during P.
Hunter, Christopher A, Couper, Kevin N, Riley, Eleanor M, Greig, Rachel, Blount, Daniel G, Blount, Daniel G., Stumhofer, Jason S, Hafalla, Julius CR, De Souza, J. Brian, Findlay, Emily Gwyer, Shaw, Tovah N, de Souza, J Brian, Riley, Eleanor M., Shaw, Tovah N., Stumhofer, Jason S., Hunter, Christopher A., Hafalla, Julius C R, Couper, Kevin N., Gwyer Findlay, Emily, Villegas-Mendez, Ana, de, Souza JB, Hunter, CA, Greig, R, Gwyer, Findlay E, Stumhofer, JS, Couper, KN, Blount, DG, Villegas-Mendez, A, Shaw, TN, Hafalla, JC, Riley, EM   +30 more
core   +1 more source

In vitro generation of interleukin-10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper 1 (Th1)- and Th2-inducing cytokines [PDF]

, 2002
We show that a combination of the immunosuppressive drugs, vitamin D3 and Dexamethasone, induced human and mouse naive CD4(+) T cells to differentiate in vitro into regulatory T cells.
Hawrylowicz, C.M., Robert L. Coffman, André Boonstra, Richards, David F, Richards, D.F., Catherine M. Hawrylowicz, Savelkoul, H.F.J., Savelkoul, HFJ (Huub), Crain, Chad, Anne O'Garra, O' Garra, A, Coffman, R.L., O'Garra, Anne, Cua, D.J., Chad Crain, Cua, DJ, Huub F. Savelkoul, Coffman, RL, Waal-Malefyt, R., de, Cua, Daniel J, Savelkoul, Huub F, Barrat, Franck J, de Waal-Malefyt, René, de Waal-Malefyt, R, Hawrylowicz, Catherine M; id_orcid, Crain, C., Barrat, FJ, Barrat, F.J., Crain, C, Coffman, Robert L, Boonstra, P.A., Daniel J. Cua, Hawrylowicz, CM, Franck J. Barrat, David F. Richards, O'Garra, A., René de Waal-Malefyt, Richards, DF, Boonstra, Andre   +38 more
core   +1 more source