Results 201 to 210 of about 14,938,680 (293)

Reduced peripheral CD4⁺ memory T-cell counts mark a mortality-associated immunophenotype in anti-MDA5 dermatomyositis. [PDF]

Front Immunol
Qian J, Ma T, Fu Q, Lian X, Chen S.
europepmc   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Circulating cell populations as response predictors and targets to improve immunotherapy in metastatic lung cancer. [PDF]

iScience
Figueiredo AB, Evangelista GFB, Ferreira SMI, Kuil LM, Barbeta G, Iohan LC, Faccio AT, Cardozo KHM, Carvalho VM, Cavalcanti CM, Balderas R, Lopes RP, Turner J, Souza-Silva TG, Silva JCS, Avila JP, Nakaya HTI, Galdino NAL, Lopes AD, Morais KLP, Santos IP, Freitas HC, Gross JL, Pinto CAL, Chojniak R, Dutra WO, Cordeiro-de-Lima VC, Gollob KJ.   +27 more
europepmc   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Distinct cytotoxic cell subsets underlie protective and non-protective immunity to African swine fever virus. [PDF]

Emerg Microbes Infect
Marín-Moraleda D, Tort-Miró A, Ezcurra E, Montaner-Tarbes S, Muñoz-Basagoiti J, Coatu E, Navas MJ, Muñoz M, Monleon P, González-Oliver J, Pailler-García L, Pina-Pedrero S, Accensi F, Rodríguez F, Argilaguet J.   +14 more
europepmc   +1 more source

Cytomegalovirus Esophagitis and Colitis, Esophageal Candidasis and Colon Amebiasis in an HIV Patient with More than 200/.MU.l CD4-positive T Lymphocytes

The Journal of AIDS Research, 2003
YOTSUMOTO, Mihoko, NAKAMURA, Naoshi, KITANO, Kiyoshi, KAMIJYO, Koji, ORII, Kouji, KIYOSAWA, Kendo   +5 more
openaire   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

High-throughput, multiplex immunofluorescence for the computer-automated immunophenotyping of Mycosis Fungoides. [PDF]

JID Innov
McMullan P, Benoit MR, Gasek N, Riddick S, Masison J, Ferenczi K, Rowe D, Weston G.   +7 more
europepmc   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Nef as a driver of immunodeficiency and HIV-associated diseases: insights from mouse models. [PDF]

Front Immunol
Yakovleva AS, Gorshkova EA, Gubernatorova EO, Bukrinsky MI, Nedospasov SA, Drutskaya MS.   +5 more
europepmc   +1 more source