Results 221 to 230 of about 15,816,019 (291)

Naive T cell-depleted hematopoietic stem cell transplantation to minimize immunosuppression after solid organ transplantation: case report. [PDF]

Commun Med (Lond)
Pérez-Martínez A, Aguirre-Portolés C, Mestre-Durán C, Arreola NM, Pascual-Miguel B, Stringa P, López Oliva MO, Papa-Gobbi R, González-Sacristán R, Gasior M, Marcos A, de Paz R, Alonso JM, Al-Akioui-Sanz K, Pertíñez L, Ferreras C, Tobes R, Pareja E, Balas A, Vicario JL, Estébanez B, Muñoz Fernández de Legaria M, Ramos-Boluda E, Sanz S, Jiménez C, Camps O, Andrés AM, Hernández-Oliveros F.   +27 more
europepmc   +1 more source

Single‐Cell RNA Sequencing of Peripheral Blood Defines Two Immunologic Subtypes of Sjögren's Disease Distinguished by Anti‐SSA Antibodies and Aberrant B Cell Populations

Arthritis &Rheumatology, EarlyView.
Objective Sjögren's disease (SjD) is a heterogeneous autoimmune disorder characterized by substantial clinical and molecular diversity. This heterogeneity raises key questions regarding the existence of distinct pathogenic mechanisms underlying disease subtypes.
Geoffrey Urbanski, Kimberly E. Taylor, Emily Flynn, Armita Norouzi, Catherine Chu, Brittany Davidson, Arnab Ghosh, Joanne Nititham, Ravi K. Patel, Annie W. Poon, Gabriela K. Fragiadakis, Alexis J. Combes, Walter L. Eckalbar, Lindsey A. Criswell, Chun Jimmie Ye, Caroline H. Shiboski   +15 more
wiley   +1 more source

Multifocal Inflammatory Pseudotumor Involving the Orbit, Skull Base, and Cauda Equina Causing Progressive Visual Loss in a Patient With HIV Infection: A Case Report. [PDF]

Cureus
Tokunaga K, Nakata H, Yasunaga JI.
europepmc   +1 more source

Early Synovial Regulatory T Cell Engagement in Posttraumatic Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective Posttraumatic osteoarthritis (PTOA) develops despite restoration of joint biomechanics, suggesting that early postinjury biologic processes within the synovium shape disease trajectories. We investigated whether synovial Treg cells are engaged during the early phase following joint injury and whether experimental enrichment of this ...
Xueyou Zhang, Mingde Cao, Jianting Li, Bruma Sai‐Chuen Fu, Michael Tim‐Yun Ong, Patrick Shu‐Hang Yung   +5 more
wiley   +1 more source

Primary Cutaneous Follicular Helper T-Cell Lymphoma: A Clinicopathological Study of Six Cases and Review of the Literature. [PDF]

J Cutan Pathol
Xie J, Li Z, Zhou X, Zheng Y, Zhang Y, Xu Y, Qin C, Li X.   +7 more
europepmc   +1 more source

Extraintestinal Reprogramming of Colon‐Derived CD4+ Intraepithelial Lymphocytes Reveals a Mechanism Underlying the Gut–Joint Axis

Arthritis &Rheumatology, EarlyView.
Objective The gut–joint axis is a central paradigm in spondyloarthritis, yet the cellular mechanisms linking intestinal and joint immunity remain poorly understood. One potential link is T cell receptor αβ+ CD4+ colon intraepithelial lymphocytes (cIELs) that can traffic to extraintestinal tissues, including the joint.
Sarah M. Danielson, Connor Eck, Sucai Liu, Anna Helena Jonsson, Kristine A. Kuhn   +4 more
wiley   +1 more source

Nonpathogenic SIV Infection in Sooty Mangabeys Is Characterized by a Lack of Activation and Expansion of Monocytes. [PDF]

J Med Primatol
Soulas C, Nguyen HD, Siddiqui S, Stahr N, Burdo TH, Novembre FJ, Kim WK, Williams KC.   +7 more
europepmc   +1 more source

Differentiation and Pathological Significance of Tissue‐Resident Memory‐Like CD8+ T Cells in Systemic Lupus Erythematosus

Arthritis &Rheumatology, Accepted Article.
Objective Tissue‐resident memory T (TRM) cells have been implicated in organ‐specific immune pathology; however, the pathological relevance of TRM‐like CD8+ T cells in systemic lupus erythematosus (SLE) remains unclear. We investigated their differentiation mechanisms and pathological significance in SLE, including associations with disease activity ...
Yuya Fujita, Kaoru Yamagata, Satoshi Kubo, Ippei Miyagawa, Koshiro Sonomoto, Yurie Satoh‐Kanda, Masanobu Ueno, Shumpei Kosaka, Aya Nawata, Yoshiya Tanaka, Shingo Nakayamada   +10 more
wiley   +1 more source

Cell and Gene Therapies Manufacturing Challenges and Integrated Good Manufacturing Practices Solutions: A Lifecycle Perspective

Biotechnology and Bioengineering, EarlyView.
Lifecycle perspective on cell and gene therapy manufacturing challenges and enabling GMP solutions. ABSTRACT Cell and gene therapies (CGTs) are revolutionizing modern medicine; however, making these advanced medicines scalable and readily available to commercial manufacturers worldwide is a major challenge. The number of approved CGT products continues
Rajath Samaga, Udisha Singh, Sachin Dattram Pawar   +2 more
wiley   +1 more source

A <i>Zap70</i> gain-of-function mutation alters mouse thymic maturation. [PDF]

Front Immunol
Vico-Barranco I, Zhang F, Grégoire C, Fernández-Aguilar LM, Arbulo-Echevarria MM, Narbona-Sánchez I, Muñoz-Fernández R, Malissen B, Malissen M, Aguado E.   +9 more
europepmc   +1 more source