Results 241 to 250 of about 831,770 (328)

Cytomegalovirus Esophagitis and Colitis, Esophageal Candidasis and Colon Amebiasis in an HIV Patient with More than 200/.MU.l CD4-positive T Lymphocytes

The Journal of AIDS Research, 2003
YOTSUMOTO, Mihoko, NAKAMURA, Naoshi, KITANO, Kiyoshi, KAMIJYO, Koji, ORII, Kouji, KIYOSAWA, Kendo   +5 more
openaire   +1 more source

Pro-inflammatory intestinal Th17-cells are tissue-resident, accumulate in the epithelia in Crohn's disease, and predict unresponsiveness to vedolizumab. [PDF]

J Crohns Colitis
Paroni M, Faggiano C, Righetti C, Dusetti I, Ranzani V, Moschetti G, Noviello D, Vasco C, Vecchi M, Landini P, Facciotti F, Abrignani S, Caprioli F, Geginat J.   +13 more
europepmc   +1 more source

Pt‐TiO2 mesoporous nanosystem co‐delivering phlorezin enables synergistic sonodynamic‐chemoimmunotherapy for hepatocellular carcinoma via directly targeting DDX5 and metabolic reprogramming modulation

BMEMat, EarlyView.
Abstract Hepatocellular carcinoma (HCC), ranking as the third leading cause of cancer‐related mortality globally, continues to pose significant therapeutic challenges. Here, we developed an innovative nanosystem, Phl@PT, based on Pt‐TiO2 nanoparticles for the co‐delivery of Phlorezin, presenting a novel approach for HCC treatment through sonodynamic ...
Kairui Liu, Bo Zhang, Yue Wan, Zhiru Yang, Abdusami Abdurahman, Mengxin He, Shengtao Hu, Yi Zhang, Xiaoke Li, Jin Chang, Jun Kang, Liren Liu, Wanghua Liu, Shao Li   +13 more
wiley   +1 more source

eIF3e-mediated translational checkpoint maintains immune tolerance and prevents lymphoid malignancy. [PDF]

J Exp Med
Lin L, Chen P, Wang J, Huang C, Lin X, Liu C, Liao K, Wu J, Chadburn A, Zhang Y, Song H, Wang C, Wan Z, Zhao J, Cao G, Wang X, Yang L, Yao N, Hong Y, Xiao Z, Wolf DA, Liu WH, Xiao C.   +22 more
europepmc   +1 more source

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

BMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning, Yunhan Sun, Mingyang Li, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongdong Liu, Fen Zhao, Guiqiang Zhang, Xiao Fu   +10 more
wiley   +1 more source

Predictive value of peripheral blood lymphocytes for glaucoma susceptibility: a clinical observational study. [PDF]

BMC Ophthalmol
Yu J, Li Y.
europepmc   +1 more source

Transfersomes with core and surface‐loaded NF‐κB p65 siRNA for enhanced transdermal transfection and effective treatment of psoriasis

BMEMat, EarlyView.
TCPL, a transfersome with Tween 80 and PEI, enables efficient transdermal siNF‐κB delivery, resolving PEI's toxicity issue. It promotes lysosomal escape and effective transfection, silences NF‐κB, modulates immunity, and inhibits angiogenesis, alleviating psoriasis. With good biocompatibility, TCPL holds strong clinical translation potential. Schematic
Hui Xing, Yuhui Yang, Ziyi Zhao, Kai Lv, Yiran Shao, Zhi Zhang, Dong Ma   +6 more
wiley   +1 more source

Immunohistochemical Study of the Tumor Immune Microenvironment in p16-Positive and p16-Negative Oral Squamous Cell Carcinoma and Its Prognostic Implications. [PDF]

Diagnostics (Basel)
Barcan ID, Stoia-Djeska TS, Rakitovan M, Zara F, Closca RM, Cindrea AC, Banta AM, Militaru AG, Urechescu H, Horhat ID.   +9 more
europepmc   +1 more source

Integrated spherical nucleic acid nanoreactor mobilizes targeted PD‐L1 proteolysis and cuproptosis for robust breast cancer immunotherapy

BMEMat, EarlyView.
This study provides an integrated spherical nucleic acid nanoreactor (denoted as AMCuD) for targeted PD‐L1 degradation and chemo‐dynamically enhanced cuproptosis to synergically elicit robust immunotherapy against the triple‐negative breast cancer (TNBC) growth, recurrence and metastasis.
Ningxi Li, Honglin Huang, Qianyi Zeng, Li Zeng, Ziman Yang, Jinyang Shen, Shun Li, Hong Yang, Yiyao Liu, Chunhui Wu   +9 more
wiley   +1 more source

Integrating network pharmacology with ex-vivo analysis to assess the effect of IL-2 in halting breast cancer: involvement of Treg/CTLA-4/Blimp-1/caspase-3. [PDF]

Sci Rep
Shousha SA, Ibrahim SSA, Kadry H, Youssef EA, Qabany Y, Darwish AA, Metwea A, Baheeg SA, Shahine Y.   +8 more
europepmc   +1 more source