Results 251 to 260 of about 314,055 (282)

The Immunomodulatory Role of CD4-Positive Cytotoxic T-lymphocytes in Health and Disease

International Reviews of Immunology, 1999
Among the CD4-positive (CD4+) T-lymphocytes a population exists which expresses cytolytic activity. These 'killer' cells belong to the T helper type 1 (Th1) subset and if activated, express Fas-ligand (FasL) which induces apoptosis in Fas-positive target cells. The major targets of these CD4+ cytotoxic T-lymphocytes (CTL) are cells of the immune system,
Sinuhe Hahn, Peter Erb
openaire   +4 more sources

Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts

Molecular Immunology, 1987
Mouse monoclonal antibodies (MAbs) have been prepared against rat T cell blasts. One MAb called MRC OX-40 recognized an antigen that differed from any previously described in that its expression was detected only on T blasts that also expressed the CD4 antigen.
Wilfred A. Jefferies, D.J. Paterson, Alan F. Williams, J R Green, M. Puklavec, P. Corthesy, Malcolm R. Brandon   +6 more
openaire   +4 more sources

CD4-positive T lymphocytes are required for the generation of the primary but not the secondary CD8-positive cytolytic T lymphocyte response to herpes simplex virus in C57BL/6 mice

Cellular Immunology, 1991
To understand the cellular basis for recovery from HSV infection, it is critical to identify functional interactions between HSV-specific T lymphocyte subpopulations involved in the generation of the optimal response. To this end, the requirement for CD4+ (L3T4+) T lymphocytes in the development of the primary and secondary CD8+ (Lyt-2+) cytolytic T ...
Stephen R. Jennings, Robert Chervenak, Patrick M. Smith, Robert H. Bonneau, R. Michael Wolcott   +4 more
openaire   +4 more sources

Profiles of cytokines produced by CD4-positive T lymphocytes stimulated by anti-CD3 antibody in patients with chronic hepatitis C

Journal of Gastroenterology, 1998
Helper T cells (Th) are classified as type 1 (Th1) and type 2 (Th2) according to the cytokines they produce; interferon-gamma is produced by Th1, and interleukin-4 by Th2. We counted the circulating CD4-positive Th cells that produce interferon-gamma or interleukin-4 with an enzyme-linked immunospot assay.
Toshihiko Miura, Atushi Kanno, Toshihiro Satoh, Yutaka Miyazaki, Hiroshi Suzuki, Koju Kobayashi, Yoshiyuki Ueno, Takehiko Igarashi, Yoshiaki Yajima, Motoyasu Ishii, Katsuaki Ukai, Takayoshi Toyota   +11 more
openaire   +4 more sources

CD4-positive T-lymphocytes can oxidatively modify low density lipoprotein

Biochemical Society Transactions, 1993
David S. Leake, David J. Lamb
openaire   +4 more sources

Depletion of CD4-positive T-lymphocytes enhances post-stroke endogenous neurogenesis

Neuroscience Research, 2010
Orie Saino, Akiko Doi, Akihiko Taguchi, Masashi Takata, Tomohiro Matsuyama, Shin-ichiro Kashiwamura, Takayuki Nakagomi, Nobutaka Doe   +7 more
openaire   +3 more sources

CD4-POSITIVE AND B LYMPHOCYTES IN TRANSPLANTATION IMMUNITY

Transplantation, 1993
The elimination of CD4+ cells by anti-CD4 antibody caused regression of a malignant solid tumor allograft that does not lose a cytotoxic T lymphocyte-defined target antigen during tumor progression and requires specific CD8+ CTL for tumor rejection. Treatment with anti-CD4 antibody was effective when started 1-2 weeks after tumor challenge and was at ...
Donald A. Rowley, Hans J. Stauss, Hans Schreiber, Hartmut Koeppen, Sunanda Singh, Ben Ho Park   +5 more
openaire   +3 more sources

Conservation of characteristics and functions of CD4 positive lymphocytes in a teleost fish

Developmental & Comparative Immunology, 2011
The presence of helper and cytotoxic T cells in fish has been suggested, although T cell subsets have yet to be identified at the cellular level. In order to investigate the functions of CD4 and CD8α positive T cells we attempted to produce and characterize monoclonal antibodies (mAbs) against teleost CD4 and CD8α.
Yuzuru Suzuki, Kyosuke Araki, Hideaki Toda, Teruyuki Nakanishi, Takeshi Yabu, Takuhito Koike, Tadaaki Moritomo, Hiroaki Suetake, Yasutaka Saito, Fumio Takizawa, Mitsuru Ototake, Tomonori Somamoto   +11 more
openaire   +3 more sources

Glutathione homeostasis is disturbed in CD4‐positive lymphocytes of HIV‐seropositive individuals

European Journal of Clinical Investigation, 1998
BackgroundNumerous in vitro tests have suggested that a disturbed cellular glutathione homeostasis plays an important role in the pathogenesis of human immunodeficiency virus (HIV) infection.MethodsUsing validated high‐performance liquid chromatography (HPLC) methods, glutathione concentrations were determined in plasma and in cytosol of CD4 ...
Ven, A.J.A.M. van der, Blom, H.J., Peters, W.H.M., Jacobs, L., Verver-Jansen, T.J.G., Koopmans †, P.P., Demacker, P.N.M., Meer, J.W.M. van der   +7 more
openaire   +4 more sources

Recombinant human erythropoietin treatment of chronic renal failure patients normalizes altered phenotype and proliferation of CD4-positive T lymphocytes.

Artificial Organs, 2010
Patients with chronic renal failure (CRF) receive recombinant human erythropoietin (rhEPO) for the correction of anemia. However, rhEPO also has an immunomodulatory effect.
K. Lisowska, A. Dębska-Ślizień, Monika Radzka, J. Witkowski, B. Rutkowski, E. Bryl   +5 more
semanticscholar   +1 more source