Results 271 to 280 of about 347,385 (305)

Removal of Autologous Activated CD4 Positive T Lymphocytes Also Result in Increased Colony-Forming Units (CFUs) in Patients with Myelodysplastic Syndromes.

Blood, 2009
Abstract Abstract 4862 Autologous activated CD4+ T lymphocytes (CD4+/CCR5+ double positive cells) in BMNC of 29 MDS patients were depleted or plused in in vitro cultures. That cultures with removed CD4+/CCR5+ cells exhibited significantly increased CFU generation.
Zheng Zhang, Xiao Li, Qingqiao Zhang, Qi He, Feng Xu, Lingyun Wu   +5 more
openaire   +1 more source

Resistance of CD4-positive T lymphocytes to etoposide-induced apoptosis mediated by upregulation of Bcl-xL expression in patients with HTLV-I-associated myelopathy

Journal of Neuroimmunology, 2001
Human T-lymphotropic virus type I (HTLV-I)-associated myelopathy (HAM) is characterized by chronic inflammation of the spinal cord. The exact mechanisms that enhance the development of chronic myelopathy remain to be determined. One such mechanism could be an altered response of peripheral blood CD4(+) T lymphocytes to apoptotic stimuli.
S, Hamasaki, T, Nakamura, T, Furuya, A, Kawakami, K, Ichinose, T, Nakashima, Y, Nishiura, S, Shirabe, K, Eguchi   +8 more
openaire   +2 more sources

[Clinicopathologic correlation between CD4-positive T lymphocyte counts and superficial lymphadenopathy in HIV-positive/AIDS patients].

Zhonghua bing li xue za zhi = Chinese journal of pathology, 2012
To explore the clinicopathological correlation between CD4(+) T lymphocyte count and superficial lymphadenopathy HIV/AIDS patients.A total of 1066 HIV/AIDS patients were included in this study. The incidence of superficial lymphadenopathy, peripheral blood CD4(+) T lymphocyte counts and histological features of superficial lymphadenopathy were analyzed.
Xiang-chan, Lu, Jian-ning, Deng, Ai-chun, Huang, Xue-qin, Li, Min-hong, Mou, Ru-zhi, Ou, Lei, Huang, Min, Zhao   +7 more
openaire   +1 more source

Modeling Changes in CD4-positive T-Lymphocyte Counts after the Start of Highly Active Antiretroviral Therapy and the Relation with Risk of Opportunistic Infections The Aquitaine Cohort, 1996–1997

American Journal of Epidemiology, 2001
Abstract After initiation of a treatment for human immunodeficiency virus type 1 infection containing a protease inhibitor, immune restoration associated with increases in CD4-positive (CD4+) T lymphocyte count may be delayed. In a sample of patients who had been prescribed protease inhibitors for the first time, the authors tested to ...
C, Binquet, G, Chêne, H, Jacqmin-Gadda, V, Journot, M, Savès, D, Lacoste, F, Dabis   +6 more
openaire   +2 more sources

Modulation of Eg5 activity contributes to mitotic spindle checkpoint activation and Tat‐mediated apoptosis in CD4‐positive T‐lymphocytes

The Journal of Pathology, 2014
AbstractTat, the transactivation factor of human immunodeficiency virus type 1 (HIV‐1), represents one of the major players mediating the loss of CD4‐positive T‐lymphocytes in HIV‐1‐infected patients, primarily due to the ability of Tat to trigger apoptosis. However, the molecular events underlying this process remain elusive. In this study, we provide
Min, Liu, Dengwen, Li, Lei, Sun, Jie, Chen, Xiaodong, Sun, Linlin, Zhang, Lihong, Huo, Jun, Zhou   +7 more
openaire   +2 more sources

Peptide specificity of alloreactive CD4 positive T lymphocytes directed against a major histocompatibility complex class I disparity.

Transplantation, 1997
The mouse strains C57BL/6 (B6, H2b) and Kbm1 mutant bm1 have a defined difference of three amino acids at position 152, 155, and 156 in the MHC class I K molecule. This causes a change in the side and the bottom of the antigen presenting groove of the K molecule resulting in strong allogeneic responses in vitro and in vivo.
M A, Ossevoort, M L, De Bruijn, K J, Van Veen, W M, Kast, C J, Melief   +4 more
openaire   +1 more source

[Effect of CD4-positive T lymphocyte expression rate on pain control and prognosis in stage Ⅳ non-small cell lung cancer patients with cancerous pain].

Zhonghua yi xue za zhi, 2022
Objective: To investigate the effect of CD4-positive T lymphocyte expression rate on the pain control and prognosis of stage Ⅳ non-small cell lung cancer (NSCLC) patients with cancerous pain. Methods: The clinical data of 128 stage Ⅳ NSCLC patients with cancerous pain who were admitted to the Affiliated Cancer Hospital of Zhengzhou University from ...
H, Chen, D P, Guo, C, Liu, G H, Wu, Y W, Li, B F, Fan, G L, Xie   +6 more
openaire   +1 more source

TNF-alpha mediated apoptosis of CD4 positive T-lymphocytes. A model of T-cell depletion in HIV infected individuals.

European journal of medical research, 1998
Apoptosis has been suggested to account for loss of CD4+ T-cells in HIV infected individuals. Aside from MHC II dependent superantigens no mediator for preferential apoptosis of CD4+ T-cell has been described. However, the expression of TNF-alpha is increased in HIV+ patients.
S A, Klein, J M, Dobmeyer, T S, Dobmeyer, D, Falke, D, Kabelitz, K, Friese, E B, Helm, D, Hoelzer, R, Rossol-Voth   +8 more
openaire   +1 more source

CD4-positive T-lymphocytes can oxidatively modify low density lipoprotein

Biochemical Society Transactions, 1993
D J, Lamb, D S, Leake
openaire   +2 more sources

[Analysis on dynamic variations of CD4-Positive T-Lymphocytes counts and influencing factors among patients receiving highly active antiretroviral therapy in Guangxi Zhuang autonomous region].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi, 2016
To understand dynamic variation of CD4-Positive T-Lymphocytes counts and influencing factors among patients receiving highly active anti-retroviral therapy (HAART) in Guangxi.Adult patients who received antiviral treatment for the first time after 1 January 2013 were selected.
He, Jiang, Qiuying, Zhu, Guanghua, Lan, Wei, Liu, Chongxing, Zhou, Zhiyong, Shen   +5 more
openaire   +1 more source