Results 281 to 290 of about 463,708 (346)

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Evaluation of the safety and immunogenicity of a peptide vaccine against canine leishmaniosis: a double-blind, multicenter, controlled clinical trial in dogs. [PDF]

Vet Q
Hurtado-Morillas C, Mas A, Orden JA, de Urbina-Fuentes L, Blanco MM, Domínguez-Bernal G, Martínez-Rodrigo A.   +6 more
europepmc   +1 more source

A Murine Database of Structural Variants Identifies A Candidate Gene for a Spontaneous Murine Lymphoma Model

Advanced Science, EarlyView.
We analyzed long‐read genomic sequencing data obtained from 40 inbred mouse strains to produce a large database of structural variants. This dataset captures the major types of structural variants, which includes deletions, insertions, duplications, and inversions.
Wenlong Ren, Zhuoqing Fang, Egor Dolzhenko, Christopher T. Saunders, Zhuanfen Cheng, Victoria Popic, Gary Peltz   +6 more
wiley   +1 more source

Spatial profiling of HPV-stratified head and neck squamous cell carcinoma reveals distinct immune niches and microenvironmental architectures. [PDF]

J Transl Med
Markovits E, Klymyshyn D, Froumine R, Zong H, Mints M, Mahadevan S, Bloom K, Bates J, Thomas GJ, Diehl L, Puig O, Aggarwal A.   +11 more
europepmc   +1 more source

Intratumoral Fusobacterium nucleatum Drives Cancer‐Associated Fibroblasts Enrichment and Immune Exclusion in Esophageal Squamous Cell Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
Fusobacterium nucleatum contributes to the progression of ESCC by inducing NF‐κB–mediated inflammatory signaling in tumor cells and promoting CAFs activation. Its presence may facilitate immune exclusion and tumor invasion through stromal remodeling. Furthermore, F.
Takashi Ofuchi, Qingjiang Hu, Kazuki Omachi, Kosuke Kanemitsu, Hajime Otsu, Yusuke Yonemura, Taro Tobo, Yoshifumi Baba, Masaaki Iwatsuki, Koshi Mimori   +9 more
wiley   +1 more source

A Rare Case of Primary Cutaneous Epstein-Barr Virus-Positive T Follicular Helper Cell Lymphoma. [PDF]

Cureus
Okamoto O, Oyama Y, Maruyama R, Nagamatsu K, Takeshita M.   +4 more
europepmc   +1 more source

Disentangling Coincident Cell Events Using Deep Transfer Learning and Compressive Sensing

Advanced Intelligent Systems, EarlyView.
Overlapping cells during detection distort single‐cell measurements and reduce diagnostic accuracy. A hybrid framework combining a fully convolutional neural network with compressive sensing to disentangle overlapping signals directly from raw time‐series data is presented.
Moritz Leuthner, Rafael Vorländer, Oliver Hayden   +2 more
wiley   +1 more source

Age-stratified immune characteristics in central nervous system tuberculosis patients: a comparative T lymphocyte subset analysis within a cohort of 862 extrapulmonary tuberculosis patients. [PDF]

BMC Infect Dis
Chen M, Zhang F, Liu Y, Lin Y, Wu D, Chen X.   +5 more
europepmc   +1 more source

Efectos de la vacunación antigripal sobre el porcentaje de linfocitos T CD4 positivos en pacientes VIH 1/2 positivos: estudio de una cohorte Effects of influenza vaccination on the percentage of CD4+ T lymphocytes in HIV 1/2 positive patients: a cohort study

, 2009
Leslie Barrionuevo Rosas, Cristina Masuet‐Aumatell, Josep Ramón   +2 more
openalex   +1 more source

A Murine Bispecific Antibody Efficiently Redirects T Cells Against Calr Mutated Stem Cells In Vivo

American Journal of Hematology, EarlyView.
ABSTRACT Calreticulin (CALR) mutations are prevalent in 20%–30% of patients with BCR::ABL1‐negative myeloproliferative neoplasms (MPN). Mutant calreticulin (mutCALR), presented by the thrombopoietin receptor (MPL, also known as TPOR or CD110) on the surface of the disease‐initiating MPN progenitors, represents an ideal target for curative ...
Shengen Xiong, Tamara Wais, Cecilia Varga, Christina Schueller, Sarada Achyutuni, Robert Kralovics   +5 more
wiley   +1 more source