Results 281 to 290 of about 314,352 (325)

Tumor Microenvironment in Melanoma-Characteristic and Clinical Implications. [PDF]

Int J Mol Sci
Sikorski H, Żmijewski MA, Piotrowska A.
europepmc   +1 more source

A tolerogenic plasmid inhibits autoantibody production triggered by immunization with human peptidyl arginine deiminase 4.

Arthritis &Rheumatology, Accepted Article.
Objectives Rheumatoid arthritis (RA) is usually preceded and likely mediated by autoantibodies to citrullinated proteins (ACPAs) that recognize citrulline residues on multiple proteins. Conversion of arginine into citrulline is performed by enzymes called peptidyl arginine deiminases (PADs).
Philippe P. Pagni, Vijetha Kumar, Nathalie C. Lambert, Eva Frison, Herve Luche, Marielle Mello, Magali Torres, Johnna D. Wesley, Matthias von Herrath, Jean Roudier, Isabelle Auger   +10 more
wiley   +1 more source

Is immune effector cell-associated enterocolitis a CAR T-cell lymphoproliferative disorder? [PDF]

Blood Cancer J
Somay K, Azakli H, Chahine JJ, Loughney TM, Ozdemirli M.   +4 more
europepmc   +1 more source

Engineering antibodies with cancer‐associated binding sites

BMEMat, EarlyView.
This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian, Yumeng Pan, Yingchun Zhang, Fangling Wang, Zejun Wang   +4 more
wiley   +1 more source

Immunopathological Dysregulation in Acute Myeloid Leukemia: The Impact of T-bet, RORγt, and FOXP3 on Disease Dynamics. [PDF]

Cells
Mohy El-Din AMM, AlShaarawy BA, Kandeel EZ, AlDewi DM, Refaat LAA, Arneth B, Sabit H.   +6 more
europepmc   +1 more source

Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities

BMEMat, EarlyView.
This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan, Ye Zhu, Zhi Ye, Huayang Zhang, Junxi Wang, Guozhong Yi, Zhiyong Li, Rongyang Xu, Luyao Wang, Zhenzhen Wu, Songtao Qi, Guanglong Huang, Shanqiang Qu   +12 more
wiley   +1 more source

Patterns of inflammation and immune activation by coreceptor use in people living with HIV-1. [PDF]

Front Immunol
Guerra-Castillo FX, Pinto-Cardoso S, Ávila-Ríos S, Chávez-Torres M, Peralta-Prado A, González-Torres C, Gaytán-Cervantes J, Requena-Benitez B, Díaz-Rivera D, Alaez-Verson C, Hernández-García MC, Bekker-Méndez VC.   +11 more
europepmc   +1 more source

Harnessing nanomaterials to precisely regulate the immunosuppressive tumor microenvironment for enhanced immunotherapy

BMEMat, EarlyView.
The immunosuppressive tumor microenvironment, characterized by hypoxia, redox imbalance, elevated interstitial fluid pressure, and acidity, was comprehensively elucidated. This review discussed the etiology and consequences of the characteristics of the immunosuppressive tumor microenvironment, and analyzed the recent advancements in nanomaterials for ...
Wen Zhang, Xueyin Hu, Wei Cheng, Lumeng Zhang, Yuanfang Chen, Qinrui Fu, Luntao Liu, Saijun Fan   +7 more
wiley   +1 more source

A preliminary study through lymphocyte immunophenotyping of the effects of different forms of phosphorus deficiency on dairy cattle blood haematological parameters and immune status. [PDF]

J Vet Res
Abramowicz B, Kurek Ł, Lisiecka U, Żarczyńska K.   +3 more
europepmc   +1 more source

5‐Aza combined with VPA reprograms human T lineage acute leukemia Jurkat cells into B‐cell‐like cells by epigenetic activation of PAX5

Biotechnology Progress, EarlyView.
Abstract Epigenetic regulation plays an important role in cell fate reprogramming. Here, we found that inhibitors of epigenetic modifiers, including VPA, TSA, and 5‐Aza‐2'‐deoxycytidine, can induce phenotypic transformation from Jurkat cells into B‐cell‐like cells. When Jurkat cells were treated with 5‐Aza combined with VPA, B cell and stem cell marker
Wenjin Xi, Guoxu Zheng, Xu Chen, Baile Zuo, Wei Wang, Yufang Li, Chunmei Zhang, Jie Chu, Xiuli Mu, Weihong Wen, Tao Wang, An‐Gang Yang   +11 more
wiley   +1 more source