Results 11 to 20 of about 1,048,882 (334)

IL-15 augments TCR-induced CD4⁺ T cell expansion in vitro by inhibiting the suppressive function of CD25High CD4⁺ T cells [PDF]

, 2012
Due to its critical role in NK cell differentiation and CD8(+) T cell homeostasis, the importance of IL-15 is more firmly established for cytolytic effectors of the immune system than for CD4(+) T cells. The increased levels of IL-15 found in several CD4(
Boonefaes, Tom, Dooms, Hans, Grooten, Johan, Leclercq, Georges, Van Belle, Tom, Wei, Xiao-Qing   +5 more
core   +8 more sources

HLA Class-II Associated HIV Polymorphisms Predict Escape from CD4+ T Cell Responses. [PDF]

, 2015
Antiretroviral therapy, antibody and CD8+ T cell-mediated responses targeting human immunodeficiency virus-1 (HIV-1) exert selection pressure on the virus necessitating escape; however, the ability of CD4+ T cells to exert selective pressure remains ...
Allen, S, Bansal, A, Carlson, J, Dilernia, D, Du, VY, Erdmann, N, Gilmour, J, Goepfert, PA, Heath, S, Hunter, E, Jureka, A, Lakhi, S, Schaefer, M, Sidney, J, Sterrett, S, Tang, J, Yue, L   +16 more
core   +6 more sources

Machine Learning Classification Model for Functional Binding Modes of TEM-1 β-Lactamase

Frontiers in Molecular Biosciences, 2019
TEM family of enzymes is one of the most commonly encountered β-lactamases groups with different catalytic capabilities against various antibiotics. Despite the studies investigating the catalytic mechanism of TEM β-lactamases, the binding modes of these
Feng Wang, Li Shen, Hongyu Zhou, Shouyi Wang, Xinlei Wang, Peng Tao   +5 more
doaj   +1 more source

Assessing very advanced HIV disease in adolescent girls and young women

Southern African Journal of HIV Medicine, 2023
Background: South Africa has the largest HIV epidemic globally, with ~7.5 million people living with HIV in 2021. Adolescent girls (AG) and young women (YW), aged 15–19 years and 20–24 years, are twice as likely to be living with HIV as their male ...
Naseem Cassim, Lindi-Marie Coetzee, Manuel P. da Silva, Deborah K. Glencross, Wendy S. Stevens   +4 more
doaj   +1 more source

The rate of CD4 decline as a determinant of progression to AIDS independent of the most recent CD4 count [PDF]

, 1998
The data of two cohort studies of HIV-infected individuals were used to examine whether the rate of CD4 decline is a determinant of HIV progression, independent of the most recent CD4 count.
Lee, CA, Lepri, AC, Pezzotti, P, Phillips, AN, Rezza, G, Sabin, CA   +5 more
core   +1 more source

Sphingosine-1-phosphate promotes the persistence of activated CD4 T cells in inflamed sites [PDF]

, 2017
Inflammation can be protective or pathogenic depending on context and timeframe. Acute inflammation, including the accumulation of CD4 T cells, accompanies protective immune responses to pathogens, but the presence of activated CD4 T cells at sites of ...
Ammit, Barnden, Brinkmann, Brown, Chimen, Cyster, Debes, Faust, Firestein, Fu, Garrod, Gibson, Han, Hochreiter-Hufford, Hugues, Jo, Karuppuchamy, Kitano, Ledgerwood, Liao, Limaye, Lindquist, Mackay, Mackay, Mammoto, Masopust, Matloubian, Matsuura, McInnes, Means, Mempel, Mendoza, Murphy, Nowarski, Olivera, Priceman, Pyne, Sawicka, Skon, Smith, Spangrude, Tarrason, Teijeira, Tsunemi, Veres, Wang, Wang   +46 more
core   +7 more sources

Factors associated with antiretroviral treatment initiation amongst HIV-positive individuals linked to care within a universal test and treat programme: early findings of the ANRS 12249 TasP trial in rural South Africa [PDF]

, 2016
Prompt uptake of antiretroviral treatment (ART) is essential to ensure the success of universal test and treat (UTT) strategies to prevent HIV transmission in high-prevalence settings.
Andréa Gosset, Bruno Spire, Camelia Protopopescu, Collins Iwuji, Deenan Pillay, François Dabis, Grimsrud A., Health Systems Trust (South Africa), Joanna Orne-Gliemann, Joseph Larmarange, Kroenke K., Mélanie Plazy, Nonhlanhla Okesola, Nuala McGrath, Sylvie Boyer, WHO   +15 more
core   +3 more sources

Impact of fixations on anti-genetic determinants of CD4, CD68, and Pax8 immunohistochemistry: A comparative study of NBF, Zink formalin, and Bouin's fluid [PDF]

Iraqi Journal of Veterinary Sciences
Fixation inhibits autolysis and is an essential step in disease. Our work examined how neutral buffer NBF (NBF), zinc formalin (ZF), and Bouin's fluid (BF) affected tissue specific CD4, CD68, and Pax8 anti-genetic determinants.
Amani A. Alayash, Firas M. Abed
doaj   +1 more source

Evaluation of CD4+ T Cells in HIV Patients Presenting with Malaria at the University of Ilorin Teaching Hospital Nigeria [PDF]

, 2009
CD4 count is an important immunological marker of disease progression in HIV seropositive patients. This study was carried out to determine the effect of malaria or fever of unknown origin on the population of CD4+ T lymphocytes of HIV seropositive ...
Louis O. Odeigha, Olajide O. Agbede, Olatunji M. Kolawole, Samuel A. Babatunde, Temitope O. Ajiboye   +4 more
core   +2 more sources

Simultaneous expression of CD4 and CD8 antigens by a substantial proportion of resting porcine T lymphocytes [PDF]

, 1987
The existence of four subpopulations in resting porcine T lymphocytes is documented. In addition to the two known subpopulations which are typified by a mutually exclusive expression of either the CD8 or the CD4 differentiation antigen, CD4-CD8+ and CD4 ...
Bevan, Bielefeldt Ohmann, Blue, Blue, Davignon, Fazekas de St. Groth, Goverman, Jonjić, Lanier, Lanier, MacDonald, Mackay, Pescovitz, Pescovitz, Reinherz, Reinherz, Saalmüller, Scollay, Swain, Tumbleson   +19 more
core   +3 more sources