Immunodominance of lytic cycle antigens in Epstein-Barr virus-specific CD4+ T cell preparations for therapy. [PDF]
Epstein-Barr virus (EBV) is associated with a number of human malignancies. EBV-positive post-transplant lymphoproliferative disease in solid organ and hematopoietic stem cell transplant recipients has been successfully treated by the adoptive transfer ...
Burdach, S. +36 more
core +1 more source
Seven year review of retention in HIV care and treatment in federal medical centre Ido-Ekiti
INTRODUCTION: poor retention of patients in care is a major driver of poor performance and increased morbidity and mortality in HIV/AIDS programme despite the expansion and advancement Anti-retroviral Therapy (ART).
Oluwole Adeyemi Babatunde +6 more
doaj +1 more source
Cryptococcus Infection and Lymphocytopenia: An Ill Defined Entity [PDF]
Cryptococcus neoformans infections are rare. Meningitis by Cryptococcus is well known as an opportunistic infection. It is most commonly seen in immuno-suppressed patients, especially in retrovirus infections and chemotherapy patients. Herein we describe
Venkat Janardhan Rama Reddy +3 more
doaj +1 more source
HLA‐Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapy [PDF]
We assessed the influence of human leukocyte antigen (HLA) alleles HLA-Bw4 and HLA-Bw6 on CD4 T cell recovery after starting successful combination antiretroviral therapy in 265 individuals. The median gains in the CD4 T cell count after 4 years were 258
Battegay, Manuel +42 more
core +2 more sources
Infectious mononucleosis is a widespread disease caused by certain members of Herpesviridae family. Acute infectious mononucleosis develops predominantly in children and is accompanied by an increase of the number of circulating naive CD4+ and naive CD8+
E. N. Filatova +4 more
doaj +1 more source
VIOLATION OF THE ACTIVITY OF CERTAIN T-CELL SUBPOPULATIONS IN SEVERE COVID-19
COVID-19 is a highly pathogenic viral infection caused by the SARS-CoV-2 coronavirus. The study of adaptive immunity to SARSCoV-2 is important for understanding the pathogenesis of the novel coronavirus infection COVID-19, the development of vaccines and
S. A. Kan, E. O. Ostapchuk
doaj +1 more source
Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue [PDF]
The upper respiratory tract mucosa is the location for commensal Streptococcus (S.) pneumoniae colonization and therefore represents a major site of contact between host and bacteria.
Mitchell, T.J. +28 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Objective/Background: Chronic lymphocytic leukemia is one of the commonest leukemias affecting adults. CD39 inhibits T-cell and Natural killer (NK) cell responses by hydrolyzing adenosine triphosphate and adenosine diphosphate, suppressing the immune ...
Eman Mosaad Zaki +5 more
doaj +1 more source
On the markers for schizophrenia
Summary. The study of various markers indicating an imbalance in both the neurotransmitter and immune systems observed in patients with schizophrenia is currently of great scientific and practical interest.
A. N. Erichev +4 more
doaj +1 more source

