Results 11 to 20 of about 783,957 (260)

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans [PDF]

open access: yesFEBS Open Bio
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Muller L   +3 more
europepmc   +2 more sources

CD4 expression decrease by antisense oligonucleotides. Inhibition of rat T CD4+ cell reactivity [PDF]

open access: yes, 2012
In previous studies, we have demonstrated the inhibition of CD4 expression in rat lymphocytes treated with phorbol myristate acetate (PMA) by antisense oligonucleotides (AS-ODNs) directed against the AUG start region of the cd4 gene.
Franch i Masferrer, Àngels   +6 more
core   +1 more source

Human CD4+ Memory T Cells Can Become CD4+IL-9+ T Cells [PDF]

open access: yes, 2010
Background: IL-9 is a growth factor for T- and mast-cells that is secreted by human Th2 cells. We recently reported that IL-4+TGF-β directs mouse CD4+CD25−CD62L+ T cells to commit to inflammatory IL-9 producing CD4+ T cells.
Popoola, Joyce   +17 more
core   +2 more sources

Tracking Virus-Specific CD4+ T Cells during and after Acute Hepatitis C Virus Infection [PDF]

open access: yes, 2007
Background. CD4+ T cell help is critical in maintaining antiviral immune responses and such help has been shown to be sustained in acute resolving hepatitis C.
Paul Klenerman   +175 more
core   +2 more sources

Assessing very advanced HIV disease in adolescent girls and young women

open access: yesSouthern African Journal of HIV Medicine, 2023
Background: South Africa has the largest HIV epidemic globally, with ~7.5 million people living with HIV in 2021. Adolescent girls (AG) and young women (YW), aged 15–19 years and 20–24 years, are twice as likely to be living with HIV as their male ...
Naseem Cassim   +4 more
doaj   +1 more source

Impact of fixations on anti-genetic determinants of CD4, CD68, and Pax8 immunohistochemistry: A comparative study of NBF, Zink formalin, and Bouin's fluid [PDF]

open access: yesIraqi Journal of Veterinary Sciences
Fixation inhibits autolysis and is an essential step in disease. Our work examined how neutral buffer NBF (NBF), zinc formalin (ZF), and Bouin's fluid (BF) affected tissue specific CD4, CD68, and Pax8 anti-genetic determinants.
Amani A. Alayash, Firas M. Abed
doaj   +1 more source

CD4 cell count recovery among HIV-infected patients with very advanced immunodeficiency commencing antiretroviral treatment in sub-Saharan Africa. [PDF]

open access: yes, 2006
BACKGROUND: Patients accessing antiretroviral treatment (ART) programmes in sub-Saharan Africa frequently have very advanced immunodeficiency. Previous data suggest that such patients may have diminished capacity for CD4 cell count recovery.
Myer, Landon   +12 more
core   +2 more sources

Enumeration of CD4+ T-Cells Using a Portable Microchip Count Platform in Tanzanian HIV-Infected Patients [PDF]

open access: yes, 2011
Background CD4+ T-lymphocyte count (CD4 count) is a standard method used to monitor HIV-infected patients during anti-retroviral therapy (ART). The World Health Organization (WHO) has pointed out or recommended that a handheld, point-of-care, reliable,
Gurkan, U.A   +35 more
core   +2 more sources

CD4+count-guided interruption of antiretroviral treatment [PDF]

open access: yes, 2006
BACKGROUND:Despite declines in morbidity and mortality with the use of combination antiretroviral therapy, its effectiveness is limited by adverse events, problems with adherence, and resistance of the human immunodeficiency virus (HIV).METHODS:We ...
Babiker, A   +73 more
core   +1 more source

Antiretroviral treatment cohort analysis using time-updated CD4 counts: assessment of bias with different analytic methods. [PDF]

open access: yes, 2011
BACKGROUND: Survival analysis using time-updated CD4+ counts during antiretroviral therapy is frequently employed to determine risk of clinical events.
Lewis, James J   +23 more
core   +1 more source

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