Results 21 to 30 of about 576,540 (264)

Effect of pembrolizumab on CD4+CD25+, CD4+LAP+ and CD4+TIM-3+ T cell subsets [PDF]

Clinical and Experimental Immunology, 2019
Summary Tumor immune evasion involves the expansion of avidly proliferating immunosuppressive cells and inhibition of effector T cell proliferation. Immune checkpoints (IC) block the activation pathways of tumor-reactive T cells. IC pathways are often exploited by tumor cells to evade immune destruction, and blocking these pathways ...
S M Toor, V Sasidharan Nair, G Pfister, E Elkord   +3 more
openaire   +2 more sources

Cryptococcus Infection and Lymphocytopenia: An Ill Defined Entity [PDF]

Journal of Clinical and Diagnostic Research, 2019
Cryptococcus neoformans infections are rare. Meningitis by Cryptococcus is well known as an opportunistic infection. It is most commonly seen in immuno-suppressed patients, especially in retrovirus infections and chemotherapy patients. Herein we describe
Venkat Janardhan Rama Reddy, S Brunda, Amit Kulkarni, BG Chenna Keshava   +3 more
doaj   +1 more source

ROLE OF CD95 AND DR3 RECEPTORS IN NA VE T-LYMPHOCYTES APOPTOSIS IN CHILDREN WITH INFECTIOUS MONONUCLEOSIS DURING CONVALESCENCE

Инфекция и иммунитет, 2017
Infectious mononucleosis is a widespread disease caused by certain members of Herpesviridae family. Acute infectious mononucleosis develops predominantly in children and is accompanied by an increase of the number of circulating naive CD4+ and naive CD8+
E. N. Filatova, E. V. Anisenkova, N. B. Presnyakova, E. A. Kulova, O. V. Utkin   +4 more
doaj   +1 more source

VIOLATION OF THE ACTIVITY OF CERTAIN T-CELL SUBPOPULATIONS IN SEVERE COVID-19

Актуальные проблемы теоретической и клинической медицины, 2022
COVID-19 is a highly pathogenic viral infection caused by the SARS-CoV-2 coronavirus. The study of adaptive immunity to SARSCoV-2 is important for understanding the pathogenesis of the novel coronavirus infection COVID-19, the development of vaccines and
S. A. Kan, E. O. Ostapchuk
doaj   +1 more source

Modulation of CD4 by suramin [PDF]

Clinical and Experimental Immunology, 1993
SUMMARYSuramin is a polysulphonated compound which can selectively bind to, and inhibit the activity of, a wide range of growth factors. There has been renewed interest recently in suramin as an anti-cancer agent and therefore we have studied its effects on lymphocyte subset populations and recombinant human IL-2 (rhIL-2) activation on lymphocytes in ...
P D, Allen, D H, Johnston, M G, Macey, N S, Williams, A C, Newland   +4 more
openaire   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Impact of CD39 expression on CD4+ T lymphocytes and 6q deletion on outcome of patients with chronic lymphocytic leukemia

Hematology/Oncology and Stem Cell Therapy, 2019
Objective/Background: Chronic lymphocytic leukemia is one of the commonest leukemias affecting adults. CD39 inhibits T-cell and Natural killer (NK) cell responses by hydrolyzing adenosine triphosphate and adenosine diphosphate, suppressing the immune ...
Eman Mosaad Zaki, Asmaa Mohamed Zahran, Alshimaa Abdelazeem Metwaly, Rania Hafez, Safinaz Hussein, Abdallah Elaiw Mohammed   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The Protective Role of L-carnitine on Immune Function in Mice Infected with E. coli [PDF]

Journal of Applied Veterinary Sciences
This study aimed to examine the immunological, molecular, and histopathological changes induced by L-carnitine supplementation in BALB/c mice infected with Escherichia coli.
Taghreed Humadai, Sabrin Mohsin, Roua Mohamed   +2 more
doaj   +1 more source

On the markers for schizophrenia

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2021
Summary. The study of various markers indicating an imbalance in both the neurotransmitter and immune systems observed in patients with schizophrenia is currently of great scientific and practical interest.
A. N. Erichev, I. I. Bode, V. O. Polyakova, A. P. Kotsubinsky, B. G. Butoma   +4 more
doaj   +1 more source